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All Journal Radioterapi & Onkologi Indonesia Oto Rhino Laryngologica Indonesiana
Prajogi, Gregorius Ben
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Education Health Professions Medicine & Pharmacology Physics Other

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Epidemiology of 10 Cancer Types in Indonesia: A Multicenter Study Jayalie, Vito Filbert; Gondhowiardjo, Soehartati; Kotambunan, Charity; Apriantoni, Riyan; Manuain, Donald Arinanda; Hawariy, Salik; Prajogi, Gregorius Ben; Permata, Tiara Bunga Mayang; Handoko, Handoko; Munandar, Arie; Sekarutami, Sri Mutya
Radioterapi & Onkologi Indonesia Vol 14, No 1 (2023): Volume 14 No.1 July 2023
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i2.161

Abstract

Cancer remains one of the largest contributors to the burden of health and mortality around the world. A study estimated 19.3 million new cases of cancer in the year 2020. GLOBOCAN 2020 provides a list of the most common cancers in the world which are prostate, lung, and colorectal cancers in men and breast, colorectal, and lung cancer in women. Naturally, different sociodemographic and geographic characteristics will cause disparities in these estimates. Since valid epidemiological data on cancer types in Indonesia remains unavailable, this study intended to provide data on the pattern of distribution of the 10 most common cancer types amongst various hospitals in Indonesia. This was achieved through the collection of registries and/or medical records that were obtained from March to September 2022. The data were then sorted and analyzed using SPSS 20.0. The resulting epidemiological data in multi-centers in Indonesia yielded a similar top 10 most common cancers trend with the GLOBOCAN 2020 worldwide incidence, although some differences were seen. A universal similarity that is found amongst different databases seems to be the prevalence of breast cancers, which always ‘champions’ all databases as the most common cancers among women. This provides a reflection for policy and decision makers for their prompt action to promote the prevention, diagnosis, and treatment of cancers in Indonesia, especially breast cancers.
Peran radioterapi lokoregional pada kasus karsinoma nasofaring dengan metastasis jauh: laporan serial kasus berbasis bukti Mayangsari, Ika Dewi; Rahman, Muhammad Ade; Adham, Marlinda; Prajogi, Gregorius Ben; Cahyanur, Rahmat; Safitri, Eka Dian
Oto Rhino Laryngologica Indonesiana Vol. 53 No. 2 (2023): VOLUME 53, NO. 2 JULY - DECEMBER 2023
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v53i2.638

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Background: Nasopharyngeal carcinoma (NPC) is a highly metastatic head and neck cancer primarilytreated with platinum-based chemotherapy. The oligometastasis hypothesis proposed by Hellman andWeichselbaum suggested that controlling the primary tumor through locoregional radiotherapy couldsignificantly improve prolonged disease-free survival. Purpose: To evaluate the effectiveness of combining locoregional radiotherapy with chemotherapy for metastatic NPC. Case series report: The first case involved a 57-year-old male with NPC at T4N3M1 (lungs) with partial response to chemotherapy, who then underwent concurrent chemoradiotherapy. However, his condition deteriorated after completing chemoradiation. The second case featured a 56-year-old male with NPC at T4N3M1 (liver), exhibiting partial response to chemotherapy and remaining at a stable condition after concurrent chemoradiotherapy. Method: Using specific keywords based on clinical questions in the PubMed, Cochrane, EBSCOhost, and Proquest databases. Inclusion criteria, exclusion criteria, and critical appraisal were carried out to find relevant studies. Result: Eleven articles were appraised critically based on the Oxford Centre for Evidence-based Medicine (CEBM) worksheet and include the validity, importance, and applicability in clinical scenarios. Conclusion: Metastatic NPC patients had better overall survival outcomes when treated with locoregional radiotherapy and systemic chemotherapy. Predictive factors influencing survival included oligometastasis, locoregional radiotherapy, chemotherapy response, lactate dehydrogenase, C-reactive protein, EBV DNA, total chemotherapy administration, Karnofsky performance score, number of metastatic lesions, and liver metastases. Platinum-based chemotherapy combined with locoregional radiotherapy could be considered as a management approach for cases of oligometastatic NPC.Keywords: nasopharyngeal carcinoma, chemotherapy, metastasis, overall survival, radiotherapy
Co-Authors Apriantoni, Riyan Arie Munandar Handoko Handoko Hawariy, Salik Kotambunan, Charity Manuain, Donald Arinanda Marlinda Adham Mayangsari, Ika Dewi Permata, Tiara Bunga Mayang Rahman, Muhammad Ade Rahmat Cahyanur Safitri, Eka Dian Sekarutami, Sri Mutya Soehartati Gondhowiardjo Vito Filbert Jayalie, Vito Filbert