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An Indonesian Pregnant Woman with Lung Cancer and Liver Metastasis : A Case Report Jayalie, Vito Filbert; Priantono, Dimas; Amin, Zulkifli
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Lung cancer in pregnancy is a rare disease compared to other types of cancer. However, special issue should be applied in order to maximize benefit for mother without harming the fetus.Methods: We present a case of 37-year-old, five months pregnant woman who came to the hospital with chief complain of shortness of breath. Later on, she was found to have a stage IV Non-Small Cell Lung Cancer (NSCLC) with adenocarcinoma subtype.Result: This may be the first lung cancer in pregnancy reported in Indonesia. Being a developing country, several challenges emerged before diagnosing patient of having lung cancer.Conclusion: Careful considerations along with multidisciplinary approach are necessary to provide the best care for the patient.

PENGETAHUAN DAN SIKAP TERHADAP SITUASI BENCANA DAN KEGAWATDARURATAN: SEBUAH STUDI MULTISENTER Vito Filbert Jayalie; Beryliana Maya Anisa; Rania Zahra; Luther Holan Parasian; Caren Andika Surbakti; Nela Lutfiana; Adrian Reynaldo Sudirman; Lintang Sekar Sari; Indah Nur Rachmah; Hasna Ibadurrahmi; M. Sopiyudin Dahlan; Riyadh Firdaus; Indonesia Emergency Knowledge and Attitude Evaluator Team
Majalah Kedokteran Indonesia Vol 68 No 12 (2018): Journal of The Indonesian Medical Association Majalah Kedokteran Indonesia Volu
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jinma.v68i12.204

Pendahuluan: Sebagai ?ring of fire?, Indonesia memiliki tingkat kerentanan tinggi terhadap bencana. Hal ini seharusnya memiliki korelasi positif terhadap tingkat pengetahuan dan sikap masyarakat dalam menghadapi kondisi gawat darurat dan bencana. Namun, belum ada studi yang menelaah mengenai hal ini. Penelitian ini bertujuan untuk menilai pengetahuan dan sikap masyarakat Indonesia dalam kondisi gawat darurat dan bencana dengan menggunakan studi potong lintang yang dikumpulkan dari wawancara menggunakan kuesioner oleh mahasiswa kedokteran yang telah terlatih pada empat unit (Jakarta, Depok, Padang, dan Makassar).Metode: Sampel dikumpulkan dengan menggunakan cluster random sampling. Dari 570 sampel yang berpartisipasi, kebanyakan responden memiliki pengetahuan (56,1%) dan sikap (60,7%) yang buruk dalam menghadapi kondisi gawat darurat dan bencana.Hasil: Hasil studi ini juga menunjukan terdapat hubungan yang signifikan antara pengetahuan dan sikap (p<0,001). Usia, pendidikan, dan pelatihan menghadapi bencana memiliki kontribusi signifikan terhadap pengetahuan dan sikap masyarakat dalam menghadapi kondisi kegawatan dan bencana. Namun, pengalaman bencana hanya memiliki korelasi terhadap pengetahuan (p<0.05) tetapi tidak dengan sikap (p=0,856).Kesimpulan: Sebagian besar populasi dalam penelitian ini memiliki pengetahuan dan sikap yang rendah pada situasi gawat darurat. Selain itu, data di atas juga menunjukkan bahwa pelatihan dapat memberikan efek pada kesiapan masyarakat dalam menghadapi bencana. Oleh karena itu, penelitian lanjutan diperlukan.

Peran Metformin sebagai Inhibitor Jaras Insulin-like Growth Factor-1 Receptor (IGF-1R), Epidermal Growth Factor Receptor (EGFR), dan Mammalian Target of Rapamycin (mTOR) pada Kemoterapi Kanker Paru Filbert Jayalie, Vito; William, Andy; -, Shelly; Irawan, Cosphiadi
Cermin Dunia Kedokteran Vol 43, No 6 (2016): Metabolik
Publisher : PT. Kalbe Farma Tbk.

Kanker paru adalah salah satu jenis kanker dengan prevalensi dan mortalitas yang tinggi di dunia. Beberapa studi klinis menunjukkan bahwa metformin dapat menurunkan angka mortalitas berbagai jenis kanker, termasuk kanker paru. Metformin dapat menghambat berbagai jaras persinyalan, seperti Insulin-like Growth Factor Receptor (IGF-1R), Epidermal Growth Factor Receptor (EGFR), dan mammalian Target of Rapamycin (mTOR), yang berperan dalam pertumbuhan dan proliferasi sel kanker. Selain itu, metformin juga memiliki efek sinergis dengan kemoterapi standar, yaitu dapat meningkatkan survival rate serta mengurangi dosis kemoterapi. Masih diperlukan penelitian lebih lanjut untuk mengetahui potensi kombinasinya dengan kemoterapi standar pada pengobatan kanker paru.

Xerostomia Severity and Quality of Life After Nasopharyngeal Cancer Radiotherapy: Intensity Modulated vs Two-dimensional Radiation Therapy in Indonesia Soehartati Argadikoesoema Gondhowiardjo; Nikrial Dewin; Andreas Ronald; Vito Filbert Jayalie; Handoko Handoko; Sri Mutya Sekarutami; Zanil Musa
Radioterapi & Onkologi Indonesia Vol 11, No 2 (2020): VOLUME 11 NO.2 JULY 2020
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v11i2.116

Introduction: Two-dimensional technique (2DRT) is most commonly used in Indonesia. This technique causes severe late toxicity particularly in nasopharyngeal cancer (NPC). Radiation techniques such as Intensity-Modulated Radiation Therapy (IMRT) and Three-Dimensional Conformal Radiation Therapy (3DCRT) provide larger doses at the site of NPC while preserving normal tissue. This study aims to compare late side effects and quality of life (QoL) between IMRT and 2DRT groups.Method: This was a cross-sectional study with consecutive sampling. Salivae samples were collected at least 6 months after last radiation date. Xerostomia severity were determined by measuring whole saliva flow rate which then categorized based on Common Terminology Criteria for Adverse Events (CTCAE). European Organization for Research and Treatment of Cancer (EORTC) core questionnaire and EORTC head and neck module (QLQ-H&N35) wereused to assess QoL.Result: The IMRT group had higher saliva flow rate than 2DRT group (1,085 ±0,409 vs 0,188 ± 0,219 stimulated, 0,500±0,254 vs 0,196 ±0,156 unstimulated, p<0.001). According to CTCAE, IMRT group experienced less grades 2 and 3 of xerostomia compared to 2DRT group (p<0.05). Moderate correlation between recovery time and saliva flow rate (p<0.05) was found in IMRT group at least 6 months after last radiation date. QLO-C30 scores were higher in IMRT group than those in 2DRT group, particularly in global health status, physical functioning, emotional functioning, pain and insomnia (p<0.05). IMRT group scored better in several QLQ-H&N35 subscales namely head and neck pain, swallowing, speech problems, trouble with social eating, trouble with social contact, dry mouth (p<0.05) and sticky saliva (p<0.001).Conclusion: IMRT was significantly superior to 2DRT in preserving and sparing the salivary gland especially parotid and improving quality of life .Thus, we recommend to treat NPC cases in Indonesia with IMRT to reduce toxicity of the treatment and improve quality of life, as it commonly affects people at productive age.

The Applicability of Neutrophil-Lymphocyte Ratio in Predicting The Survival of Nasopharyngeal Cancer: An Evidence Based Case Report Vito Filbert Jayalie; Nadiyya Faza Zhafirah; Sri Mutya Sekarutami
Radioterapi & Onkologi Indonesia Vol 12, No 1 (2021): VOLUME 12 NO.1 JANUARY 2021
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v12i1.132

Background: Having high prevalence and mortality with a distinctive geographical distribution, nasopharyngeal cancer (NPC) has caused a huge burden in the world. There are several prognostic factors in NPC, however additional marker is needed to give a better picture on disease outcome. Innate and adaptive immunity play a great role in disease progression, however, the role of neutrophil-lymphocyte ratio (NLR) is still controversial. This study aims to investigate the role of NLR status as a prognostic factor in NPC. Methods: Literature searching was conducted through Pubmed, Cochrane, Proquest, EBSCO and Science Direct under specific keywords. Further filtering double and screening for eligibility criteria were performed before critical appraisal and measurement of level of evidence by The Centre for Evidence-Based Medicine (CEBM) University of Oxford. Review for the best available evidence was done by two-independent reviewer.Results: 130 records were retrieved and 6 final articles were finally appraised. All studies were published after 2017 with sample sizes of 140-5973 subjects. NLR cut-off were varied across studies (2.21-3.6) and the overall survival (OS) ranging from 51-82.5%. Moreover, 5-year disease specific survival (DSS) and progression free survival (PFS) for low and high NLR were 76-90.5% vs 53-82.1% and 68-86.2% vs 52-76.5%, respectively. Conclusion: NLR status can be used to predict OS in NPC patients. A careful approach should be taken in determining treatment options. Further research is needed to know the role of NLR in combination with other biomarker in predicting the survival of patients.

Peran Metformin sebagai Inhibitor Jaras Insulin-like Growth Factor-1 Receptor (IGF-1R), Epidermal Growth Factor Receptor (EGFR), dan Mammalian Target of Rapamycin (mTOR) pada Kemoterapi Kanker Paru Vito Filbert Jayalie; Andy William; Shelly -; Cosphiadi Irawan
Cermin Dunia Kedokteran Vol 43, No 6 (2016): Metabolik
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v43i6.68

Kanker paru adalah salah satu jenis kanker dengan prevalensi dan mortalitas yang tinggi di dunia. Beberapa studi klinis menunjukkan bahwa metformin dapat menurunkan angka mortalitas berbagai jenis kanker, termasuk kanker paru. Metformin dapat menghambat berbagai jaras persinyalan, seperti Insulin-like Growth Factor Receptor (IGF-1R), Epidermal Growth Factor Receptor (EGFR), dan mammalian Target of Rapamycin (mTOR), yang berperan dalam pertumbuhan dan proliferasi sel kanker. Selain itu, metformin juga memiliki efek sinergis dengan kemoterapi standar, yaitu dapat meningkatkan survival rate serta mengurangi dosis kemoterapi. Masih diperlukan penelitian lebih lanjut untuk mengetahui potensi kombinasinya dengan kemoterapi standar pada pengobatan kanker paru.

An Indonesian Pregnant Woman with Lung Cancer and Liver Metastasis : A Case Report Vito Filbert Jayalie; Dimas Priantono; Zulkifli Amin
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Lung cancer in pregnancy is a rare disease compared to other types of cancer. However, special issue should be applied in order to maximize benefit for mother without harming the fetus.Methods: We present a case of 37-year-old, five months pregnant woman who came to the hospital with chief complain of shortness of breath. Later on, she was found to have a stage IV Non-Small Cell Lung Cancer (NSCLC) with adenocarcinoma subtype.Result: This may be the first lung cancer in pregnancy reported in Indonesia. Being a developing country, several challenges emerged before diagnosing patient of having lung cancer.Conclusion: Careful considerations along with multidisciplinary approach are necessary to provide the best care for the patient.

The Clinical Efficacy and Safety of Simvastatin in the Management of Portal Hypertension in Cirrhotic Patients: A Systematic Review Raksheeth Agarwal; Matthew Billy; Oliver Emmanuel Yausep; Radhian Amandito; Vito Filbert Jayalie; Rino Alvani Gani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 1 (2020): VOLUME 21, NUMBER 1, April 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Variceal bleeding is a serious complication of portal hypertension in liver cirrhosis. Current guidelines recommend non-selective beta blockers (NSBBs) and endoscopic variceal ligation for primary prophylaxis of variceal bleeding. However, NSBBs are associated with low response rates and systemic adverse effects. Simvastatin has been shown to reduce portal hypertension in previous studies. Our aim was to assess its clinical efficacy and safety in reducing portal hypertension in cirrhotic patients. Method: We searched PubMed, The Cochrane Library, ScienceDirect, ProQuest, CINAHL, Scopus, and Clinicaltrials.gov, and manually browsed abstracts of major hepatology conferences for selection of studies. We selected randomized controlled trials with a population of cirrhotic patients, simvastatin as an intervention, HVPG change as an outcome, and English as the primary language. The quality of selected studies was assessed using the Cochrane Risk of Bias tool. We extracted change in HVPG from baseline to post-treatment as the principal summary measure, with safety as the secondary outcome.Results: Two full articles were included for qualitative analysis. Both studies reported reductions in HVPG from baseline to post-treatment in the simvastatin group, with this reduction being significantly higher as compared to the control group. Adverse effects were homogenously distributed in both groups, and good safety was reported by both studies. Simvastatin’s HVPG lowering effects are possibly additive to those of NSBBs. Conclusion: Simvastatin effectively reduces HVPG in cirrhotic patients with portal hypertension, although more clinical trials are needed to validate these results. Simvastatin could potentially be combined with NSBBs to achieve greater results.

Combination of Adoptive Cell Therapy and Radiotherapy in Cancer Management Vito Filbert Jayalie; Endang Nuryadi
Radioterapi & Onkologi Indonesia Vol 13, No 1 (2022): Volume 13 No.1 January 2022
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i1.137

Cancer remains a healthcare burden in the world, with the increasing cases and deaths. Adoptive cell therapy (ACT) is one of the immunotherapies which modifies immune system to recognize cancer cells, which is then transfused to induce antitumoral responses in the human body. ACT works by using cancer-specific immune cells, especially Natural Killer and T cells in the form of tumor-infiltrating lymphocytes, T-cell receptor or chimeric antigen receptor. As the combination therapy with radiotherapy, radiation is able to induce tumor-associated antigen (TAA) and major histocompatibility complex (MHC) class I expression, which leads to increased immune cells around the tumor. As the result, transferred ACT to the body may be able to proliferate and perform its function well. Moreover, radiotherapy is able to downregulate regulatory T cells and myeloid-derived suppressor cells which can inhibit the role of the immune system in attacking cancer. Clinically, studies combining radiation and ACT in cancer care are limited to several types of cancer, such as metastatic melanoma, nasopharyngeal cancer, lymphoma and non-small cell lung cancer. Radiotherapy is able to increase therapeutic efficacy, especially as a bridging therapy before ACT. Nevertheless, further trials to know the potency of combining ACT and radiotherapy in other types of cancer, especially in earlier stages are needed.

Epidemiology of 10 Cancer Types in Indonesia: A Multicenter Study Jayalie, Vito Filbert; Gondhowiardjo, Soehartati; Kotambunan, Charity; Apriantoni, Riyan; Manuain, Donald Arinanda; Hawariy, Salik; Prajogi, Gregorius Ben; Permata, Tiara Bunga Mayang; Handoko, Handoko; Munandar, Arie; Sekarutami, Sri Mutya
Radioterapi & Onkologi Indonesia Vol 14, No 1 (2023): Volume 14 No.1 July 2023
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i2.161

Cancer remains one of the largest contributors to the burden of health and mortality around the world. A study estimated 19.3 million new cases of cancer in the year 2020. GLOBOCAN 2020 provides a list of the most common cancers in the world which are prostate, lung, and colorectal cancers in men and breast, colorectal, and lung cancer in women. Naturally, different sociodemographic and geographic characteristics will cause disparities in these estimates. Since valid epidemiological data on cancer types in Indonesia remains unavailable, this study intended to provide data on the pattern of distribution of the 10 most common cancer types amongst various hospitals in Indonesia. This was achieved through the collection of registries and/or medical records that were obtained from March to September 2022. The data were then sorted and analyzed using SPSS 20.0. The resulting epidemiological data in multi-centers in Indonesia yielded a similar top 10 most common cancers trend with the GLOBOCAN 2020 worldwide incidence, although some differences were seen. A universal similarity that is found amongst different databases seems to be the prevalence of breast cancers, which always ‘champions’ all databases as the most common cancers among women. This provides a reflection for policy and decision makers for their prompt action to promote the prevention, diagnosis, and treatment of cancers in Indonesia, especially breast cancers.

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