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All Journal Medical Journal of Indonesia Radioterapi & Onkologi Indonesia Indonesian Journal of Cancer
Sekarutami, Sri Mutya
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health Other

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Epidemiology of 10 Cancer Types in Indonesia: A Multicenter Study Jayalie, Vito Filbert; Gondhowiardjo, Soehartati; Kotambunan, Charity; Apriantoni, Riyan; Manuain, Donald Arinanda; Hawariy, Salik; Prajogi, Gregorius Ben; Permata, Tiara Bunga Mayang; Handoko, Handoko; Munandar, Arie; Sekarutami, Sri Mutya
Radioterapi & Onkologi Indonesia Vol 14, No 1 (2023): Volume 14 No.1 July 2023
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i2.161

Abstract

Cancer remains one of the largest contributors to the burden of health and mortality around the world. A study estimated 19.3 million new cases of cancer in the year 2020. GLOBOCAN 2020 provides a list of the most common cancers in the world which are prostate, lung, and colorectal cancers in men and breast, colorectal, and lung cancer in women. Naturally, different sociodemographic and geographic characteristics will cause disparities in these estimates. Since valid epidemiological data on cancer types in Indonesia remains unavailable, this study intended to provide data on the pattern of distribution of the 10 most common cancer types amongst various hospitals in Indonesia. This was achieved through the collection of registries and/or medical records that were obtained from March to September 2022. The data were then sorted and analyzed using SPSS 20.0. The resulting epidemiological data in multi-centers in Indonesia yielded a similar top 10 most common cancers trend with the GLOBOCAN 2020 worldwide incidence, although some differences were seen. A universal similarity that is found amongst different databases seems to be the prevalence of breast cancers, which always ‘champions’ all databases as the most common cancers among women. This provides a reflection for policy and decision makers for their prompt action to promote the prevention, diagnosis, and treatment of cancers in Indonesia, especially breast cancers.
The Role of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients: A Literature Review Giselvania, Angela; Sekarutami, Sri Mutya; Munandar, Arie; Halim, Devina Adella; Wijovi, Felix
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1190

Abstract

Background: Globally, hepatocellular carcinoma (HCC) is the most prevalent kind of primary liver cancer. Treatment options for HCC include radiotherapy, immunotherapy, surgery, targeted therapy, transarterial chemoembolization, and hepatic arterial infusion chemotherapy. Limited efficacy was observed since 70-80% of cases are diagnosed late and unresectable. Growing evidence reported that SBRT is a viable option for locoregional treatments like radiofrequency ablation (RFA) or transarterial chemoembolization (TACE) for patients who did not respond to those treatments. Methods: A thorough search of electronic databases including PubMed, Cochrane Library, and Embase was conducted for studies on Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma published in English over the past 10 years. The review process followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to ensure a systematic approach. Inclusion criteria encompassed studies focusing on SBRT use in HCC treatment, with extracted data synthesized to provide a comprehensive overview of current evidence. Any discrepancies during the review were resolved through consultation with a third reviewer when necessary. Results: In comparison to conventional radiation therapy, Stereotactic Body Radiation Therapy (SBRT) offers precise administration of the high dose of radiotherapy, given in fewer fractions, and may be used in conjunction with other therapy modalities. Global guidelines, including in Indonesia, have proposed the implementation of SBRT. Local control was reportedly achieved in around 90–95% of HCC patients. Multimodal therapies, combined with TACE, showed superior results regarding the local control and overall survival. SBRT may eventually become the definitive treatment for early-stage HCC patients and has a critical role as a transitional therapy for patients awaiting liver transplantation. Improved outcomes and quality of life were also observed in patients with portal vein thrombosis (PVT) and extrahepatic metastases who underwent SBRT. Conclusions: SBRT results in promising local control, raises overall survival, and improves the quality of life in HCC patients with various stages.
Tumor apparent diffusion coefficient value and ratio in magnetic resonance imaging on cervical cancer Siregar, Trifonia Pingkan; Wanandi, Septelia Inawati; Darmiati, Sawitri; Kusuma, Fitriyadi; Sekarutami, Sri Mutya; Lisnawati; Prihartono, Joedo; Ilyas, Muhammad; Amalia, Ginva; Elfahmi, Khalida Ikhlasiya Tajdar Gefariena
Medical Journal of Indonesia Vol. 34 No. 2 (2025): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257715

Abstract

BACKGROUND Diffusion-weighted magnetic resonance imaging (DW-MRI) is a noninvasive, non-contrast sequence for cancer detection. Research involving DW-MRI in cervical cancer has revealed lower apparent diffusion coefficient (ADC) values. This study aimed to evaluate the difference in tumor ADC values and ADC ratios (tumor-to-urine and tumor-to-muscle) with respect to tumor staging (early versus late) and histopathology (squamous cell carcinoma versus adenocarcinoma). METHODS This retrospective study included 56 patients with cervical cancer, divided into early- and late-stage groups. DW-MRI was performed in all patients, and the tumor ADC value, ADC ratio between the tumor and urine (ADC ratiot−u), and ADC ratio between the tumor and gluteal muscle (ADC ratiot−m) were measured. Statistical methods were employed to assess the difference in the tumor ADC value, ADC ratiot−u, and ADC ratiot−m with respect to cervical cancer stages and histopathological findings. RESULTS The median tumor ADC value was lower in the early-stage group than in the late-stage cervical cancer (0.75 × 10−3 mm²/s versus 0.8 × 10−3 mm²/s, p = 0.022). However, no differences were observed in ADC ratiot−u and ADC ratiot−m concerning the tumor staging, nor in ADC value, ADC ratiot−u, and ADC ratiot−m concerning histopathological findings (p = 0.29, 0.67 and 0.35, respectively), with no significant differences in the ADC ratiot−u (p = 0.153) and ADC ratiot−m (p = 0.260). In receiver operating characteristic analysis, the tumor ADC value was 75.0% sensitive and 50.0% specific in predicting late-stage cervical cancer with a cut-off value of 0.750 × 10−3 mm2/s. CONCLUSIONS The median tumor ADC value in early-stage patients was significantly lower than in the late-stage patients, suggesting that tumor ADC value has valuable potential for characterizing cervical cancer staging.
Co-Authors Amalia, Ginva Apriantoni, Riyan Arie Munandar Darmiati, Sawitri Elfahmi, Khalida Ikhlasiya Tajdar Gefariena Fitriyadi Kusuma Giselvania, Angela Halim, Devina Adella Handoko Handoko Hawariy, Salik Joedo Prihartono Kotambunan, Charity Lisnawati Manuain, Donald Arinanda Muhammad Ilyas Permata, Tiara Bunga Mayang Prajogi, Gregorius Ben SEPTELIA INAWATI WANANDI Siregar, Trifonia Pingkan Soehartati Gondhowiardjo Vito Filbert Jayalie, Vito Filbert Wijovi, Felix