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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Cermin Dunia Kedokteran
Kurniawan, Benny Nanda
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Humanities Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Potensi Ekstrak Saw Palmetto sebagai Terapi BPH Kurniawan, Benny Nanda
Cermin Dunia Kedokteran Vol 45, No 2 (2018): Urologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i2.176

Abstract

Saw palmetto (Serenoa repens) merupakan tumbuhan yang biasa digunakan oleh suku Indian sebagai terapi tradisional dalam mengobati keluhan berkemih. Saw palmetto mengandung lauric acid, myristic acid, oleic acid, dan linoleic acid yang dapat menghambat enzim 5α-reduktase tipe 1, 2, dan berikatan dengan reseptor α-adrenergik sebagai inhibitor non-kompetitif. Kandungan fitosterol pada saw palmetto juga memiliki efek inhibisi pada beberapa growth factor seperti heparin binding epidermal growth factor (HBEGF), vascular endothelial growth factor (VEGF), dan platelet derived growth factor (PDGF). Selain itu, saw palmetto juga memicu efek anti-inflamasi pada prostat dengan cara menghambat ekspresi monocyte chemotactic protein-1 dan limfosit B, yang dapat berperan dalam progresivitas BPH.
Potensi Ekstrak Saw Palmetto sebagai Terapi BPH Kurniawan, Benny Nanda
Cermin Dunia Kedokteran Vol 45, No 2 (2018): Urologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i2.176

Abstract

Saw palmetto (Serenoa repens) merupakan tumbuhan yang biasa digunakan oleh suku Indian sebagai terapi tradisional dalam mengobati keluhan berkemih. Saw palmetto mengandung lauric acid, myristic acid, oleic acid, dan linoleic acid yang dapat menghambat enzim 5α-reduktase tipe 1, 2, dan berikatan dengan reseptor α-adrenergik sebagai inhibitor non-kompetitif. Kandungan fitosterol pada saw palmetto juga memiliki efek inhibisi pada beberapa growth factor seperti heparin binding epidermal growth factor (HBEGF), vascular endothelial growth factor (VEGF), dan platelet derived growth factor (PDGF). Selain itu, saw palmetto juga memicu efek anti-inflamasi pada prostat dengan cara menghambat ekspresi monocyte chemotactic protein-1 dan limfosit B, yang dapat berperan dalam progresivitas BPH.
Correlation Between Ultrasonography BI-RADS Classification and Histopathological Examination on Breast Tumor Patients in Gorontalo Purnomo, Frederick Johan; Kurniawan, Benny Nanda; Pranoto, Agung Sindu
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i4.58205

Abstract

Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide. Early and accurate diagnosis is crucial for improving survival rates, particularly in regions with limited access to advanced diagnostic facilities. The ultrasound (USG) examination with Breast Imaging Reporting and Data System (BI-RADS) classification standardizes breast imaging interpretation and aids in risk stratification. However, its correlation with histopathological outcomes requires further evaluation. This study aims to analyze the correlation between ultrasonographic BI-RADS classifications and histopathological findings in patients with breast tumors in Gorontalo. This study is a multicentre retrospective observational analytic with a cross-sectional approach conducted at four hospitals in Gorontalo, Indonesia. The study included patients who underwent breast ultrasonography with BI-RADS categories 3, 4, or 5, followed by histopathological confirmation between January 2023 and January 2025. The results show 75 patients, 25 (33.3%) were classified as BI-RADS category 3, 26 (34.7%) as BI-RADS category 4, and 24 (32%) as BI-RADS category 5. Histopathological examination revealed that 92% of BI-RADS 3, 53.8% of BI-RADS 4, and 8.4% of BI-RADS 5 cases were benign, while 8% of BI-RADS category 3, 46.2% of BI-RADS category 4, and 91.6% of BI-RADS category 5 were confirmed as malignant. The chi-squared test demonstrated a significant correlation between BI-RADS classifications and histopathological findings (p < 0.001). Thus, the study confirms the strong correlation between ultrasonographic BI-RADS classifications and histopathological outcomes, emphasizing its reliability in breast cancer evaluation.
Co-Authors Pranoto, Agung Sindu Purnomo, Frederick Johan