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Clindamycin 0.025% and Tretinoin 0.005% Cream for Infantile Acne Vulgaris Reginata, Gabriela; Tan, Sukmawati Tansil; Gunawan, Listyani
Cermin Dunia Kedokteran Vol 46, No 4 (2019): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Acne vulgaris is an inflammatory disease of pilosebaceous unit marked by the presence of comedones, papules, pustules, nodules, and cysts. A boy aged 4 years old was reported of having red spots on his cheeks since the age of 1 month old. Erythematous papules and pustules with white heads were found in the facial area. Infantile acne diagnosis was considered. Combination of clindamycin 0.025% and tretinoin 0.005% cream was given to accelerate healing process and to prevent complications such as post-inflammatory hyperpigmentation. The patientâ€™s condition was considerably better after 1 month.Acne vulgaris merupakan inflamasi kelenjar pilosebaceous yang ditandai dengan komedon, papula, pustula, nodula, and kista. Kasus anak laki-laki usia 4 tahun mempunyai bintik kemerahan di pipi sejak usia 1 bulan. Dijumpai papula dan pustula eritematous dengan white heads di wajah, didiagnosis sebagai infantile acne. Diberikan krim kombinasi clindamycin 0.025% and tretinoin 0.005% untuk terapi dan mencegah komplikasi hiperpigmentasi. Keadaan pasien lebih baik setelah terapi 1 bulan.

Uji Provokasi Skuama pada Pitiriasis Versikolor Tan, Sukmawati Tansil; Reginata, Gabriela
Cermin Dunia Kedokteran Vol 42, No 6 (2015): Malaria
Publisher : PT. Kalbe Farma Tbk.

Pitiriasis versikolor (PV) adalah infeksi jamur superfisial kulit yang disebabkan oleh ragi lipofilik Malassezia furfur yang merupakan organisme saprofit pada kulit normal. Aktivasi M. furfur terjadi akibat perubahan keseimbangan flora normal kulit; karena berbagai faktor, M.furfur akan berkembang menjadi bentuk mycelial yang patogenik. Pitiriasis versikolor dapat didiagnosis melalui gambaran klinis, pemeriksaan fluoresensi dengan lampu Wood, dan pemeriksaan KOH pada kerokan kulit. Pemeriksaan lain adalah uji provokasi skuama. Tes dilakukan dengan meregangkan atau menggoreskan kuku jari tangan ke lesi, sehingga skuama terlihat jelas atau disebut evoked scale sign, suatu tanda khas pitiriasis versikolor yang tidak didapatkan pada penyakit kulit lain. Cara ini mudah diaplikasikan dalam praktik sehari-hari.Pityriasis versicolor ( PV ) is a superficial fungal skin infection caused by lipophilic yeast Malassezia furfur. M.furfur is a saprophytic organism in normal skin. Activation of M. furfur is due to changes of normal flora of the skin; M.furfur will evolve into a pathogenic form of mycelia. Pityriasis versicolor can be diagnosed by clinical signs, Wood's lamp fluorescence, and KOH examination on skin scrapings. Other is scaling provocation test carried out by stretching or scraping fingernails to the lesion to reveal scaling, known as scale evoked sign, a typical sign of pityriasis versicolor. This method is easily applied in daily practice.

Pendekatan Multidisipliner Xeroderma Pigmentosum Reginata, Gabriela
Cermin Dunia Kedokteran Vol 43, No 7 (2016): Kulit
Publisher : PT. Kalbe Farma Tbk.

Xeroderma pigmentosum (XP) adalah penyakit kulit autosomal resesif, ditandai dengan gejala fotosensitivitas yang nyata. Penderitanya tidak mampu memperbaiki kerusakan DNA akibat radiasi sinar ultraviolet, menyebabkan berbagai manifestasi klinis: lentiginosis, perubahan pigmentasi, dan penuaan dini kulit, abnormalitas oftalmologik dan neurologik, sering disertai keganasan yang menyebabkan kematian. Setidaknya ada delapan bentuk XP, mulai dari XP-A hingga XP-G dan XP-varian (XP-V) yang teridentifikasi hingga saat ini. Diagnosis berdasarkan gambaran klinis yang dikonfirmasi dengan analisis seluler untuk menilai kerusakan reparasi DNA. Pendekatan tatalaksana multidisiplin sangat penting; diagnosis dini dan proteksi ketat dari pajanan sinar matahari dapat meningkatkan kualitas serta harapan hidup penderitanya.

Manifestasi Klinis Sindrom Behcet Tan, Sukmawati Tansil; Gunawan, Listyani; Reginata, Gabriela
Cermin Dunia Kedokteran Vol 43, No 10 (2016): Anti-aging
Publisher : PT. Kalbe Farma Tbk.

Sindrom Behcet adalah proses inflamasi multisistemik yang tidak diketahui etiologinya, manifestasi klinis berupa ulkus oral rekuren, ulkus genital, lesi kulit, lesi mata dan berbagai sistem organ lain. Kasus wanita 21 tahun mengeluh luka-luka kecil yang nyeri di rongga mulut sejak tiga minggu, hilang timbul hampir setiap bulan sejak lima tahun. Luka juga terdapat di kemaluan, hilang timbul sejak empat tahun dan berulang tiga hingga empat kali setiap tahun. Kedua mata merah dan berair, sejak satu tahun. Pada pemeriksaan kedua mata tampak injeksi konjungtiva dan tidak ada penurunan visus. Pada rongga mulut didapatkan ulserasi aftosa multipel berdiameter 0,6 cm. Pada vulva terdapat ulkus menggaung dengan tepi meninggi berukuran 3 cm x 1,5 cm x 0,5cm. Pasien didiagnosis sebagai sindrom Behcet berdasarkan International Classification Criteria of Behcetâ€™s Disease atau menggunakan skoring Revised International Criteria for Behcet Disease (ICBD). Pengobatan kortikosteroid dan antibiotik oral maupun topikal. Tujuan terapi adalah mempercepat penyembuhan dan mencegah remisi. Luka membaik selama tiga minggu pengobatan.Behcet's syndrome is a multisystemic inflammatory process of unknown etiology, with clinical manifestations of recurrent oral ulcers, genital ulcers, skin lesions, eye lesions, and in other organ systems. A 21-year-old woman complained of painful minor lesions in the oral cavity since three weeks, fluctuating almost every month since five years ago. Similar lesions were found in genital area intermittently three to four times a year since four years. Red and watery eyes were felt since last year. On examination, there were conjunctival injection in both eyes but no decrease in visual acuity, multiple aphthous ulceration in the oral cavity with diameter of 0.6 cm, vulval ulcers with deep and rising edge measuring 3 cm x 1.5 cm x 0,5cm. Diagnosis of Behcet's syndrome was based on the International Classification Criteria of Behcet's Disease or Revised Criteria for Behcet's Disease International (ICBD). Treatment consist of oral and topical corticosteroids and antibiotics to accelerate healing and prevent remission. The patient improved during three weeks of treatment.Â Â Â

Diagnosis dan Tatalaksana Karsinoma Sel Basal Tansil Tan, Sukmawati; Reginata, Gabriela
Cermin Dunia Kedokteran Vol 42, No 12 (2015): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Karsinoma Sel Basal (KSB) merupakan neoplasma ganas dari sel yang tidak mengalami keratinisasi pada lapisan basal epidermis, bersifat invasif lokal, agresif, destruktif, dan jarang bermetastasis. KSB lebih sering terjadi pada usia lanjut. Etiopatogenesis KSB adalah genetik, lingkungan, dan yang paling sering adalah paparan sinar ultraviolet. Secara klinis, terdapat lima tipe KSB yaitu nodular, superfisial, morpheaform, pigmented, dan fibroepitelioma Pinkus. Subtipe KSB dapat ditentukan melalui anamnesis dan manifestasi klinis, ditunjang dengan pemeriksaan histopatologi. Penatalaksanaan berdasarkan lokasi dan gambaran histopatologi. Angka kekambuhan KSB sangat rendah jika terapi tepat.Basal Cell Carcinoma (BCC) is a malignant neoplasm derived from nonkeratinizing cells originating in the basal layer of the epidermis; locally invasive, aggressive, destructive, and rarely metastasize. KSB is more common in the elderly. Etiopathogenesis associated with KSB is genetic, environmental, and most often is exposure to ultraviolet light. There are five clinical types of BCC: nodular, superficial, morpheaform, pigmented, and fibroepitelioma Pinkus. BCC subtypes can be determined from anamnesis and clinical manifestations supported by histopathological examination. Management is based on anatomic location and histopathologic features. BCC recurrence rate is very low if treated appropriately.

Efektivitas Pengobatan Pasien Melasma dengan Modalitas Kombinasi (Penggunaan Tabir Surya, Obat Topikal, Obat Sistemik, Peeling, Laser, dan Skin Booster): Laporan Kasus Andarini, Mia Yasmina; Yuwita, Wulan; Harsono, Rosalin Naomi; Virdiono, Primedhia; Reginata, Gabriela
Jurnal Integrasi Kesehatan dan Sains Vol 6, No 2 (2024): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v6i2.13687

AbstrakTata laksana melasma masih merupakan tantangan karena sering terjadi rekurensi setelah penghentian pengobatan. Prinsip dasar pengobatan melasma adalah dengan supresi aktivitas melanosit melalui penggunaan tabir surya. Supresi sintesis melanin dilakukan melalui penggunaan obat berbahan depigmentasi. Peeling kimiawi dilakukan untuk mengurangi produksi melanin. Penggunaan laser dapat membantu memecah granul melanin. Skin booster dapat mencegah proses solar elastosis karena aktivitas metaloproteinase dihambat. Dilaporkan tiga kasus melasma tipe campuran. Pada ketiga kasus ini pengobatan melasma dilakukan melalui penggunaan tabir surya, kombinasi bahan depigmentasi (hidrokuinon 4% dan tretinoin 0,025–0,1%) secara bertahap, traneksamid oral 2x250 mg, laser Yellow 577-nm Diode, dan peeling kimiawi asam glikolat 35%, serta non-cross linked asam hialuronat skin booster sebagai terapi lanjutan. Sementara itu, pada pasien melasma yang tidak menunjukkan gejala klinis eritema dan teleangiektasia diberikan pengobatan kombinasi yang sama, tetapi dengan penggunaan laser QS NdYAG. Simpulan, pengobatan melasma menggunakan modalitas kombinasi dengan penggunaan tabir surya, bahan depigmentasi, traneksamid oral, laser, peeling kimiawi, dan skin booster diketahui efektif dan tidak ada tanda rekurensi berdasarkan penurunan skor MASI setelah dua tahun pengamatan.The Effectiveness of Treatment for Melasma Patients with Combination Modalities (Using Sun Protection, Topical, Systemic Medication, Peeling, Laser, and Skin Booster): A Case ReportAbstractThe management of melasma continues to be challenging due to frequent relapses following discontinuation of the medication. The basic principles of treating melasma include the suppression of the activity of melanocytes by applying sunscreen. Depigmenting agents are used to suppress melanin synthesis. Chemical peeling can decrease melanin production, whereas laser treatment scatters melanin granules. Skin boosters protect against solar elastosis, which can reduce metalloproteinase activity. Reports indicated three cases of mixed-type melasma. In these three cases, we treated melasma using sun protection, a combination of depigmentation (4% hydroquinone and 0.025–0.1% tretinoin) gradually, 2x250 mg oral tranexamic, a 577-nm yellow light diode laser, and chemical peeling glycolic acid (35%), as well as non-cross-linked hyaluronic acid as a maintenance therapy. A patient with clinical symptoms of melasma, who does not exhibit erythema and telangiectasia, receives the same combination therapy but uses QS NdYAG laser. In conclusion, the treatment of melasma using combination modalities with sun protection, depigmentation ingredients, oral tranexamic, laser, chemical peeling, and skin booster is effective, and there is no sign of recurrence based on the reduction of the MASI score after two years of observations.

Perkembangan Teledermoskopi di Indonesia: Tinjauan Perspektif Hukum Kesehatan Reginata, Gabriela; Noviani, Karina
Cermin Dunia Kedokteran Vol 52 No 11 (2025): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i11.1677

Teledermoscopy, as a component of telemedicine, represents an important innovation in dermatological healthcare that enhances accessibility, effectiveness, and the overall quality of medical services in Indonesia. This technology provides significant benefits, particularly for communities in regions with limited access to dermatology specialists. Law Number 17 of 2023 concerning Health and Government Regulation Number 28 of 2024 serve as the primary legal foundations supporting the implementation of teledermoscopy in Indonesia. These regulations address the legality of practice, patient data protection, information security standards, and the responsibilities of healthcare professionals and electronic system providers in delivering digital health services. Teledermoscopyenables remote examination, diagnosis, and monitoring of skin lesions through digital dermoscopy devices connected to the national health information system. The technology accelerates diagnosis, facilitates referrals, and broadens access to dermatological care. With a robust legal framework, continuous professional training, and reliable digital infrastructure, teledermoscopy has the potential to become a strategic component in the transformation of Indonesia’s national healthcare system.

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