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All Journal Cermin Dunia Kedokteran CRANE: Civil Engineering Research Journal
-, Frieda
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Civil Engineering, Building, Construction & Architecture Health Professions Medicine & Pharmacology Public Health

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Terapi Kortikosteroid Sistemik untuk Sindrom Steven Johnson (SSJ)- Nekrolisis Epidermal Toksik (NET) di RSUD DR Moewardi, Surakarta, Indonesia Novi Diana, Eka Devinta; Tri Irfanti, Rakhma; Rahma, Alfina; -, Frieda; Nugraha, Wibisono; Eko Irawanto, Muhammad
Cermin Dunia Kedokteran Vol 48, No 4 (2021): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1195.538 KB) | DOI: 10.55175/cdk.v48i4.1363

Abstract

Latar belakang :Sindrom Steven Johnson (SSJ) dan nekrolisis epidermal toksik (NET) adalah manifestasi reaksi alergi obat paling berat dan mengancam jiwa yang dimediasi sel T. Salah satu terapi SSJ-NET yaitu kortikosteroid sistemik. Tujuan : Mengetahui pola terapi kortikosteroid sistemik di Instalasi Rawat Inap RSUD Dr. Moewardi Surakarta periode Januari 2014-Desember 2018. Metode : Penelitian deskriptif retrospektif atas data rekam medis pasien SJS-NET di Instalasi Rawat Inap RSUD Dr. Moewardi Surakarta periode Januari 2014-Desember 2018. Hasil : Didapatkan 80 pasien SJS-NET, usia terbanyak 46-65 tahun (39%), lebih banyak laki-laki (52%). Diagnosis SSJ paling banyak (61%) dibandingkan SSJ overlap NET (24%) maupun NET (15%) dengan keterlibatan mukosa mulut terbanyak (64%). Penyakit penyerta terbanyak adalah diabetes melitus (18 %). Penyebab SSJ-NET terbanyak diduga lebih dari satu obat (44%). Terapi kortikosteroid sistemik berupa injeksi metilprednisolon dengan rata-rata dosis 65 mg/hari dan lama perawatan 10 hari. Simpulan :Kortikosteroid sistemik merupakan terapi semua kasus SSJ-NET di RSUD dr. Moewardi Surakarta.Background: Steven Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the severest primarily T-cell mediated manifestation and life threatening drug reaction. Systemic corticosteroid is used for SJS-TEN management. Objective: To study the pattern of systemic corticosteroid therapy for SJS-TEN in Dr.Moewardi General Hospital Surakarta Januari 2014-December 2018. Method: A descriptive retrospective study on medical record data of SJS-TEN patients hospitalized at Dr.Moewardi General Hospital Surakarta between January 2014 and December 2018. Results: From a total 80 SJS–TEN patients in this study, 39% was 46-65 year-old, male (52%). The most frequent diagnosis was SJS (61%) followed by SJS overlap TEN (24%) and TEN (15%), mostly with mucosal mouth involvement (64%). The most frequent comorbidities was DM (18%). More than one drug were related to SJS-TEN (44%). Therapy for all cases was systemic corticosteroids with an average dose of methylprednisolone 65 mg per day in 10 days. Conclusion :Systemic corticosteroids was used in all cases of SSJ-NET in Dr.Moewardi General Hospital Surakarta.  
Analisis Struktur Balok Sistem Rangka Pemikul Momen Khusus Pada Menara Talawang Kota Palangka Raya Ilham, Kholik Nur; Baru, Fransisco Happy Riadi Haputra; -, Frieda
CRANE: Civil Engineering Research Journal Vol 5 No 2 (2024): CRANE
Publisher : Program Studi Teknik Sipil, Fakultas Teknik dan Ilmu Komputer, Universitas Komputer Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34010/crane.v5i2.12606

Abstract

The Talawang Tower building will be built in the center of the Great Roundabout of Palangka Raya City. The renovation of the Great Roundabout of Palangka Raya, which will be carried out by the Central Kalimantan Provincial Government through the Public Works and Spatial Planning Office (PUPR), will be built grandly with a multipurpose concept. The plan in the middle of the roundabout will be built Talawang Tower with a height of 45 meters. It takes a fairly mature analysis to avoid greater losses, especially earthquake planning analysis. Therefore, the author tries to redesign an earthquake-resistant reinforced concrete structure with an irregular structural model and shows the seismic loads acting on the structure that meets the detaling standards of the Special Moment Bearing Frame System. Planning using SAP2000 by inputting dead loads, live loads, wind loads and earthquake loads to help get the internal forces needed in planning. From the calculation results, a 500 x 650 beam is used with the longitudinal reinforcement requirement of the pedestal to withstand the load is 12D22 with a capacity of ϕMn = 723.955 kN-m > 665.192 kN-m, while the field longitudinal reinforcement requirement is 6D22 with a reinforcement capacity of ϕMn = 379.9872 kN-m > 18.4086 kN-m. The support shear reinforcement requirement is 4D13 - 130 with capacity ϕVn = 753.879 kN > 694.232 kN, while the field shear reinforcement requirement is 2D13 - 150 with capacity ϕVn = 513.47 kN > 405.02 kN.
Co-Authors Baru, Fransisco Happy Riadi Haputra Eko Irawanto, Muhammad Ilham, Kholik Nur Novi Diana, Eka Devinta Nugraha, Wibisono Rahma, Alfina Tri Irfanti, Rakhma