Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal The Indonesian Biomedical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Fardah Akil
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Gastrointestinal Stromal Tumors: A Rare Neoplasm Presenting with Gastrointestinal Bleeding Fardah Akil; HAM Akil; Tajuddin Tjambolang; N K Sungowati; M Adnan; Bachtiar Murtala; Junus Alkatiri; Santa Jota
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 8, ISSUE 1, April 2007
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/81200728-32

Abstract

Gastrointestinal stromal tumors (GIST) are rare tumors of the gastrointestinal (GI) tract that arise from primitive mesenchymal cells. GISTs occur throughout the GI tract but are usually located in the stomach and small intestine. GISTs are known with myoid, neural or mixed features of differentiation. Clinical findings are gastrointestinal bleeding, abdominal pain, and weight loss. GISTs express a heterogeneous clinical course not easily  predicted.  The  histologic  features  that  correlate  best  with  development  of recurrence and metastasis are mitotic activity, tumor size and the presence of tumor necrosis and most recently, mutation in the c-kit gene. Some authors specifically use the term GIST to refer to only those mesenchymal tumors that express CD117, whereas others believe that the diagnosis can be made in the absence of CD117 positivity based on clinical and morphologic features. Surgical resection remains the treatment of choice, since chemotherapy and radiation are ineffective. Long-term follow-up is imperative and recurrence rates are high. We report the case of a 60 years old female patient who presented with intermittent melena, chronic dyspepsia, and anemia. Upper digestive tract endoscopy showed a submucosal tumor, broad-based, centrally ulcerated, projection of 5 cm in the gastric corpus-antral wall as the cause of the upper gastrointestinal bleeding. Endoscopic biopsies were negative for neoplastic changes. After triple eradication therapy of Helicobacter pylori and treatment continued with proton pump inhibitor agent, the patient underwent distal gastrectomy with Billroth-I reconstruction. Histopatological studies on the surgical resection specimen revealed a GIST of smooth muscle with spindle cell, no evidence of mitotic activity but of uncertain biological behavior. One year after surgery the patient is was improved with no signs of residual malignancy. However, metastases were found later in the liver in the next two year.   Keywords: GIST, stromal tumor, surgery, C-kit
Snail Expression is Positively Correlated with Depth of Invasion in Colorectal Carcinoma Miskad, Upik Anderiani; Akil, Fardah; Cangara, Muhammad Husni; Dahlan, Haslindah; Hutasoit, Gina Andyka; Ilyasa, Muhammad Riza
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3392

Abstract

BACKGROUND: Colorectal carcinoma ranks as the second deadliest and third most prevalent cancer globally. The depth of tumor invasion and the presence of tumor-infiltrating lymphocytes (TILs) are linked to survival rates in this disease. Meanwhile, Snail expression is positively correlated with tumor grade, recurrence, metastasis and poor prognosis in various tumors. However, not many studies discuss the correlation of Snail expression with invasion depth and TILs in Indonesia. Therefore, this study was conducted to investigate the correlation between Snail expression and both the depth of invasion and TIL scoring in colorectal carcinoma.METHODS: A cross-sectional study was conducted to evaluate 70 paraffin-embedded blocks of colorectal carcinoma patients. Snail expression was measured with immunohistochemistry using Snail rabbit polyclonal antibody. Stromal TILs were assessed on a single full-face hematoxylin and eosin (H&E) slide, and classified into high, intermediate, and low TILs.RESULTS: The results showed that the most invasion was to the muscularis propria (42.9%) and the least invasion was to the submucosa (4.3%). In scoring TILs, the most samples with intermediate TILs (58.6%) and the least samples with low TILs (4.3%). The analysis employing a Spearman Rank coefficient shows significant positive correlation between the expression of Snail with depth of invasion (r=0.273; p=0.022) but there was no significant correlation with TILs scoring (p=0.892).CONCLUSION: Even though, there is no significant correlation between Snail expression with TILs, there is, however, a significant positive correlation between Snail expression with depth of invasion in colorectal carcinoma. Therefore, Snail expression might be potentially used as a prognostic factor in colorectal carcinoma.KEYWORDS: Colorectal, carcinoma, Snail, depth of invasion and TILs
Co-Authors Bachtiar Murtala Bachtiar Murtala Bachtiar, Rini R Bachtiar, Rini R Cangara, Husni Dahlan, Haslindah Daud, Numan AS Gina Andyka Hutasoit HAM Akil Ilyasa, Muhammad Riza Junus Alkatiri Kusuma, Susanto H Luthfi, Muhammad M Adnan N K Sungowati Rifai, Amelia Santa Jota Tajuddin Tjambolang UPIK ANDERIANI MISKAD, UPIK ANDERIANI