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All Journal Indonesian Journal of Mathematics and Natural Sciences Jurnal Penelitian Pendidikan Indonesian Journal of Pure and Applied Chemistry
M Alauhdin
Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Negeri Semarang
Biochemistry, Genetics & Molecular Biology Chemistry Education Mathematics

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SINTESIS DAN MODIFIKASI LAPIS TIPIS KITOSAN-TRIPOLIFOSFAT Alauhdin, M; Widiarti, N
Jurnal MIPA Vol 37, No 1 (2014): April 2014
Publisher : Jurnal MIPA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dalam bidang medis, kitosan telah banyak digunakan yakni pada sistem penghantaran dan pelepasan obat. Pelepasan obat dengan kitosan memiliki keterbatasan karena kitosan cepat sekali menyerap air dan memiliki derajat swelling yang tinggi sehingga menyebabkan pelepasan obat terjadi dengan cepat. Diharapkan dengan memodifikasi struktur kitosan secara kimia dapat meningkatan kelarutannya dalam pelarut-pelarut organik. Telah dilakukan sintesis dan modifikasi lapis tipis kitosan. Modifikasi dilakukan melalui pembentukan ikatan silang kitosan dengan tripolifosfat (TPP) pada kondisi asam untuk menghasilkan kitosan-TPP. Ikatan silang yang terbentuk diamati dengan FTIR. Sementara itu, pengaruh hasil pengikatan silang diamati dengan membandingkan rasio swelling kitosan-TPP pada kondisi pH yang berbeda-beda. Rasio swelling lapis tipis cenderung konstan setelah terjadi pengikatan silang kitosan dengan tripolifosfat. Reaksi tripolifosfat dengan kitosan melalui pembentukan ikatan silang menjadikan lapis tipis semakin rapat sehingga molekul air sulit untuk berdifusi masuk ke dalam struktur kitosan-tripolifosfat. Hasil ini menunjukkan bahwa pengikatan silang mampu mengurangi kelarutan dan meningkatkan sifat mekanik kitosan. Rasio swelling lapis tipis berkurang dengan adanya pengikatan silang. Hal ini mengindikasikan bahwa pengikatan silang oleh TPP dapat mengurangi hidrofilitas lapis tipis karena gugus amino yang reaktif telah bereaksi dengan ion tripolifosfat. In the medical field, chitosan has been widely used in the delivery systems and drug release. Drug release with chitosan has limitations because chitosan absorbs water very quickly and have a high degree of swelling that causes the release of the drug occurs rapidly. It is expected that by modifying the chemical structure of chitosan could improve its solubility in organic solvents. The synthesis and modification of chitosan thin film have been done. It was performed through the formation of crosslinked chitosan with tripolyphosphate (TPP) in acidic conditions to produce chitosan-TPP. The formed crosslinkings were observed using FTIR, while their influence was observed by comparing the swelling ratio of chitosan-TPP thin films at different pH values. The thin film swelling ratio tends to stable after crosslinking reaction. The crosslinking decreased water diffusion into the chitosan-TPP structures. These results showed that the crosslinking can decrease the solubility and increase the mechanical properties of the chitosan. The crosslinking also reduced the swelling ratio of thin film. It indicated that TPP crosslinking decreased hydrophility of the thin film due to the reactive amino groups of chitosan have reacted with tripolyphosphate ions.
PEMBELAJARAN KIMIA ANALITIK DASAR BERBASIS MULTIMEDIA BAGI MAHASISWA CALON GURU KIMIA Haryani, Sri; Prasetya, Agung Tri; Alauhdin, M
Jurnal Penelitian Pendidikan Vol 30, No 2 (2013)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jpp.v30i2.5678

Abstract

This research aims to design multimedia based teaching materials model of Basic Analytical Chemistry that oriented on the explanation of macroscopic and microscopic level and symbolic, and its implementation to improve the mastery of science concepts and labwork skills of student teacher candidates. The subjects consisted of 27 and 30 students of chemistry education study program who take Basic Analytical Chemistry lecture as control and experimental group respectively. Quasi-experimental design with pretest - posttest control group used in this study, and the differences of pre and post-tests result were assumed as the effects of the treatment. Mastery of concepts and skills of science process measured by description test was analyzed by comparing the value of the normalized gain (N-gain), whereas questionnaires students feedback was analysed with descriptive percentage. Learning basic analytical chemistry using a CD-oriented learning material that oriented on the structure of matter on acid-base and permanganometric titration can improve mastery of concepts and skills of science proces. The highest indicators of science process skills was classifying and the lowest was hypothesize capabilities. The advantages of learning implementations were increasing mastery of the concepts and science process skills and making a fun learning experience among the students.
SINTESIS DAN MODIFIKASI LAPIS TIPIS KITOSAN-TRIPOLIFOSFAT Alauhdin, M; Widiarti, N
Indonesian Journal of Mathematics and Natural Sciences Vol 37, No 1 (2014): April 2014
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dalam bidang medis, kitosan telah banyak digunakan yakni pada sistem penghantaran dan pelepasan obat. Pelepasan obat dengan kitosan memiliki keterbatasan karena kitosan cepat sekali menyerap air dan memiliki derajat swelling yang tinggi sehingga menyebabkan pelepasan obat terjadi dengan cepat. Diharapkan dengan memodifikasi struktur kitosan secara kimia dapat meningkatan kelarutannya dalam pelarut-pelarut organik. Telah dilakukan sintesis dan modifikasi lapis tipis kitosan. Modifikasi dilakukan melalui pembentukan ikatan silang kitosan dengan tripolifosfat (TPP) pada kondisi asam untuk menghasilkan kitosan-TPP. Ikatan silang yang terbentuk diamati dengan FTIR. Sementara itu, pengaruh hasil pengikatan silang diamati dengan membandingkan rasio swelling kitosan-TPP pada kondisi pH yang berbeda-beda. Rasio swelling lapis tipis cenderung konstan setelah terjadi pengikatan silang kitosan dengan tripolifosfat. Reaksi tripolifosfat dengan kitosan melalui pembentukan ikatan silang menjadikan lapis tipis semakin rapat sehingga molekul air sulit untuk berdifusi masuk ke dalam struktur kitosan-tripolifosfat. Hasil ini menunjukkan bahwa pengikatan silang mampu mengurangi kelarutan dan meningkatkan sifat mekanik kitosan. Rasio swelling lapis tipis berkurang dengan adanya pengikatan silang. Hal ini mengindikasikan bahwa pengikatan silang oleh TPP dapat mengurangi hidrofilitas lapis tipis karena gugus amino yang reaktif telah bereaksi dengan ion tripolifosfat. In the medical field, chitosan has been widely used in the delivery systems and drug release. Drug release with chitosan has limitations because chitosan absorbs water very quickly and have a high degree of swelling that causes the release of the drug occurs rapidly. It is expected that by modifying the chemical structure of chitosan could improve its solubility in organic solvents. The synthesis and modification of chitosan thin film have been done. It was performed through the formation of crosslinked chitosan with tripolyphosphate (TPP) in acidic conditions to produce chitosan-TPP. The formed crosslinkings were observed using FTIR, while their influence was observed by comparing the swelling ratio of chitosan-TPP thin films at different pH values. The thin film swelling ratio tends to stable after crosslinking reaction. The crosslinking decreased water diffusion into the chitosan-TPP structures. These results showed that the crosslinking can decrease the solubility and increase the mechanical properties of the chitosan. The crosslinking also reduced the swelling ratio of thin film. It indicated that TPP crosslinking decreased hydrophility of the thin film due to the reactive amino groups of chitosan have reacted with tripolyphosphate ions.
PEMBELAJARAN KIMIA ANALITIK DASAR BERBASIS MULTIMEDIA BAGI MAHASISWA CALON GURU KIMIA Haryani, Sri; Prasetya, Agung Tri; Alauhdin, M
Jurnal Penelitian Pendidikan Vol 30, No 2 (2013)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jpp.v30i2.5678

Abstract

This research aims to design multimedia based teaching materials model of Basic Analytical Chemistry that oriented on the explanation of macroscopic and microscopic level and symbolic, and its implementation to improve the mastery of science concepts and labwork skills of student teacher candidates. The subjects consisted of 27 and 30 students of chemistry education study program who take Basic Analytical Chemistry lecture as control and experimental group respectively. Quasi-experimental design with pretest - posttest control group used in this study, and the differences of pre and post-tests result were assumed as the effects of the treatment. Mastery of concepts and skills of science process measured by description test was analyzed by comparing the value of the normalized gain (N-gain), whereas questionnaires students feedback was analysed with descriptive percentage. Learning basic analytical chemistry using a CD-oriented learning material that oriented on the structure of matter on acid-base and permanganometric titration can improve mastery of concepts and skills of science proces. The highest indicators of science process skills was classifying and the lowest was hypothesize capabilities. The advantages of learning implementations were increasing mastery of the concepts and science process skills and making a fun learning experience among the students.
SINTESIS DAN KARAKTERISASI CARBON DOTS TERDOPING NITROGEN DARI DAUN JAMBU BIJI (Psidium guajava L.) UNTUK DETEKSI FE(III) Dzahaba, Fauza Vita Harira; Alauhdin, M
Indonesian Journal of Pure and Applied Chemistry Vol. 9 No. 2 (2026)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v9i2.105105

Abstract

This study aimed to synthesize and characterize nitrogen-doped carbon dots (C-dots) derived from guava leaves (Psidium guajava L.) and evaluate their potential as a fluorescent sensor for Fe(III) detection. Nitrogen-doped C-dots were synthesized via pyrolysis at different temperatures using urea as the nitrogen dopant. The synthesized C-dots were characterized for their optical properties, surface functional groups, particle size distribution, and fluorescence under 365 nm UV irradiation. The results confirmed the successful formation of nanoscale C-dots bearing hydroxyl (–OH), carboxyl (–COOH), and amino (–NH) functional groups that contribute to their fluorescence properties. The synthesis temperature significantly affected the optical characteristics and fluorescence intensity of the C-dots, with the sample prepared at 250 °C exhibiting the highest fluorescence intensity and a strong blue emission. Fluorescence sensing experiments demonstrated that Fe(III) induced greater fluorescence quenching than the other tested metal ions, indicating good selectivity toward Fe(III). These findings demonstrate that nitrogen-doped guava leaf-derived C-dots are promising as a simple, environmentally friendly, and cost-effective fluorescent sensors for Fe(III) detection in aqueous samples.
Co-Authors Agung Tri Prasetya Dzahaba, Fauza Vita Harira N Widiarti Sri Haryani