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Faktor yang Berhubungan dengan Unmeet Need Kontrasepsi pada Pasangan Usia Subur di Puskesmas Kalahien Anggraini, Farida; Kania, Nia; Febriana, Silvia Kristanti Tri; Suhartono, Eko; Triawanti
MEDIA ILMU KESEHATAN Vol 13 No 3 (2024): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v13i3.1332

Abstract

Background: Pregnancy and birth are not controlled can have a national impact due to unmet needs, apart from population explosion, it can also cause higher maternal and infant mortality rates related to unwanted pregnancies. Objective: To analyze factors related to the unmet need for contraception among couples of childbearing age at the Kalahien Community Health Center, South Barito Regency, in 2023. Methods: Quantitative research using a cross sectional approach. The sample in this study was female couples of childbearing age who were in the working area of the Kalahien Community Health Center. Sampling used non-probability sampling with purposive sampling technique was 95 people. Data was taken using a questionnaire. Data were analyzed using the chi square test and logistic regression test. Results: Obtained p-value for education variables (p=0.001 <α 0.05), level of religiosity (p=0.000 <α 0.05), access to health facilities (p=0.004 <α 0.05), and husband's support (p=0.001 <α 0.05) with unmet need for contraception. Conclusion: There is a significant relationship between education, level of religiosity, access to health facilities, and husband's support with unmet need for contraception, husband's support is the most dominant factor
Effect of Mercury Administration as an Oxidative Stress Trigger in Hepato-Renal Injuries Yuliana, Ida; Triawanti; Prenggono, Muhammad Darwin; Oktaviyanti, Ika Kustiyah; Irfan Maulana; Fahrina Ulfah
JURNAL KESEHATAN LINGKUNGAN Vol. 17 No. 2 (2025): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v17i2.2025.159-167

Abstract

Introduction: Mercury as the source of free radicals can trigger the activation of oxidative stress pathways. With its high toxicity, it can cause hepato-renal injuries. There have been many studies on mercury toxicity in various organs, but there are still few scientific studies that examine the hepato-renal injuries caused by mercury through the oxidative stress pathway. This study was conducted to investigate the triggering of the oxidative stress pathway due to mercury exposure in hepato-renal injuries. Methods: Research using randomized true laboratory experiment method with post-test control group design. The number of samples used was 28 Wistar rats. The research group consisted of 2 groups, control group was given aquadest ad libitum, and intervention group was given water contaminated with mercury per oral once a day (15 kg/WB). The treatment period was 14 consecutive days and on the 15th day, blood samples were taken. Oxidative stress marker was assessed by examining MDA and GPx levels and hepato-renal injuries were assessed by examining liver function (ALT and AST) and kidney function (ureum and creatinine). The collected data were analyzed by independent t-test with 95% confidence level; significant if p>0.05. Results and Discussion: The study found that mercury can trigger the activation of oxidative stress pathways and have an impact on hepato-renal function. Conclusion: Research still needs to be continued to prove that impaired hepato-renal injuries also occur at the cellular histomorphologic and discover other biomolecular mechanisms such as activation of inflammatory pathways that can also cause organ damage.