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All Journal Majalah Kesehatan Pharmamedika Jurnal Pengabdian Kepada Masyarakat: Dimastika
Fikri Amalia
farmasi UGM
Religion Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health Social Sciences Other

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Aktivitas Antiproliferasi Ekstrak Etanolik Herba Ciplukan (Physalis angulata L.) Terhadap Sel Hepar Tikus Betina Galur Sprague Dawley Terinduksi 7,12-Dimetilbenz[a]antrasena Agusta Fauzi, Ilham; Amalia, Fikri; Sabila, Nurma; Hermawan, Adam; Ikawati, Muthi; Meiyanto, Edy
Majalah Kesehatan Pharmamedika Vol 3, No 1 (2011): JANUARI - JUNI 2011
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v3i1.434

Abstract

One of the natural materials as potentially efficacious chemopreventive agents are Ciplukan (Physalis angulata L.). Several previous studies reported that Physalis angulata L. herbs ethanolic extract (PEE) has cytotoxic activity and induction of apoptosis in breast cancer cells MCF-7 and HeLa cervical cancer cells. This study aims to determine the effects of  PEE as an chemopreventive agent on rat liver cells induced 7,12-dimetilbenz[a]anthracene (DMBA). This study used Sprague Dawley strain female rats aged 40-50 days were divided into 5 groups : (1) DMBA control group, mice were induced with DMBA in per oral dose of 20 mg/kg; (2) DMBA + PEE dose 750 mg/kgBW group ; (3) DMBA + PEE dose 1500 mg/kgBW group ; (4) solvent control group of CMC-Na 0,5%; (5) PEE dose 1500 mg/kgBW control group. PEE was dissolved in CMC-Na 0,5% and administered daily, starting the seventh week after administration of DMBA. At the beginning of  the tenth week of the study, rats were necropted and liver organs were isolated and stored in buffered formalin 4%. Qualitative analysis to determine the histopathology of liver cells through staining method of Hematoxyllin Eosin (HE), while quantitative analysis to determine the level of liver cell proliferation by AgNOR staining method. The results showed in the DMBA control group that liver cell morphology changes that hiperproliferation leading to carcinogenesis. In DMBA + PEE dose of  1500 mg/kgBW group improved the situation of DMBA-induced liver cells histopathology and antiproliferation activity better than DMBA + PEE dose of 750 mg/kgBW on DMBA-induced rat liver cells. The results showed that Physalis angulata L. herbs ethanolic extract can inhibit cell proliferation in rat liver caused by DMBA administration through antiproliferation mechanism and have potential for the development as chemoprevention material on liver cancer
Pelatihan Pemasaran Digital bagi UMKM Desa Sojomerto: Pendekatan Berbasis Kebutuhan Lokal Kurniyah, Kurniyah; Satria, Bahtiar Raga; Mustaszar, Amir; Mubarok, Ahmad Mas’ul; Rodhiya, Ali Saidi; Wahyuni, santi; Mukaromah, Lailiya; hidayattullah, Nur Farid; Khumaedah, Isti; Wahid, Nur; Sarifah, Nadya Dian Noor; Anwaroh, Zumrotul; Amalia, Fikri; Satriani, Ayu; Laila, Miladia
Jurnal Pengabdian Kepada Masyarakat Vol 5 No 1 (2026): JURNAL PENGABDIAN KEPADA MASYARAKAT: DIMASTIKA
Publisher : LPPM Sekolah Tinggi Islam Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62509/jpkm.v5i1.376

Abstract

The rapid development of digital technology has created significant opportunities for Micro, Small, and Medium Enterprises (MSMEs) to improve their competitiveness and expand their market reach. However, many MSME actors have not yet optimally utilized digital marketing due to limited knowledge and skills. This community service activity aims to enhance the understanding and capabilities of MSME actors in digital marketing through a training seminar conducted by KKN Sojomerto 01 students. The methods employed include observation, training seminars, interactive discussions, and brief assistance. The results indicate an improvement in participants’ understanding of the use of social media and digital platforms as effective marketing tools. This activity is expected to encourage MSMEs to adapt to digital developments in order to increase sales and ensure business sustainability.
Co-Authors Adam Hermawan Agusta Fauzi, Ilham Anwaroh, Zumrotul Edy Meiyanto hidayattullah, Nur Farid Khumaedah, Isti Kurniyah Laila, Miladia Mubarok, Ahmad Mas’ul Mukaromah, Lailiya Mustaszar, Amir Muthi Ikawati Nur Wahid, Nur Nurma Sabila Rodhiya, Ali Saidi Sarifah, Nadya Dian Noor Satria, Bahtiar Raga Satriani, Ayu Wahyuni, Santi