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All Journal E-Jurnal Medika Udayana Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Green Medical Journal
Aras, Jusli
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Role of Hepcidin in Pediatric Chronic Kidney Disease with Anemia Aras, Jusli; Kardani, Astrid Kristina; Soemaryo, Ninik Asmaningsih; Prasetyo, Risky Vitria; Noer, Mohammad Sjaifullah; Ugrasena, I Dewa Gede
Green Medical Journal Vol 3 No 3 December (2021): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v3i3.87

Abstract

Introduction: Anemia is a frequent complication of chronic kidney disease (CKD) in children and it causes an increase in morbidity, mortality and accelerates the rate of progression of CKD. Inflammation and impaired kidney clearance increase plasma hepcidin, inhibiting duodenal iron absorption and sequestering iron in macrophages. However, the role of hepcidin in increasing the risk of anemia in children with CKD is still uncertain. This study aimed to investigate the association between hepcidin levels and anemia in children with pre-dialysis CKD. Methods: A cross-sectional study was conducted at Dr. Soetomo Academic Hospital from December 2018 to February 2019. Children with pre-dialysis CKD were enrolled in this study. The subject had no history of erythropoietin administration and blood transfusion 3 months before the blood sample were withdrawn. A complete blood count, ferritin serum, transferrin saturation (TSAT) and hepcidin serum were performed. The correlations between Hepcidin and ferritin level, between ferritin level and anemia, and between TSAT and anemia were analyzed using Spearman correlation and the Mann-Whitney test. Results: A total of 47 children, 27 boys and 20 girls, ranged in age from 3 months to 18 years old. There was a significant correlation between hepcidin and ferritin levels (p=0.006) and the value of the Spearman correlation was r=0.392. While the correlation between ferritin level and anemia showed a significant result, p=0.001. However, TSAT did not show any significant correlation with anemia (p=0.230). Conclusion: There was an indirect association between hepcidin level and anemia by increasing ferritin level that induces anemia in pre-dialysis CKD children.
PERBANDINGAN HASIL ANALISIS GAS DARAH ARTERI ANTARA ALAT POINT OF CARE TESTING (POCT) DAN LABORATORY BLOOD GAS ANALYZER PASIEN PNEUMONIA Indrawati, Gracia Dewi; Lawang, St. Aizah; Ganda, Idham Jaya; Rauf, Syarifuddin; L, Amiruddin; Aras, Jusli
E-Jurnal Medika Udayana Vol 12 No 3 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i03.P05

Abstract

Pneumonia masih menjadi masalah kesehatan baik dalam angka kesakitan maupun kematian. Analisis gas darah (AGD) merupakan pemeriksaan laboratorium yang memiliki peran penting dalam tatalaksana pasien pneumonia. Point of care testing (POCT) adalah alternatif alat pemeriksaan yang dapat mempersingkat waktu pemeriksaan. Tujuan penelitian ini untuk melihat perbandingan hasil AGD antara POCT dan laboratory blood gas analyzer(BGA) pasien pneumonia. Penelitian ini menggunakan studi cross-sectional yang dilakukan dari bulan oktober hingga Desember 2022 di Pediatric Intensive Care Unit(PICU) RSUP Dr. Wahidin Sudirohusodo Makassar. Penelitian melibatkan 60 sampel AGD arteri yang akan diperiksa menggunakan POCT, setelah itu dilakukan pemeriksaan BGA. Hasil penelitian menunjukkan Terdapat hubungan signifikan untuk semua parameter AGD (pH, pCO2, pO2, HCO3) antara kedua alat (p=0,000). Kekuatan hubungan sangat kuat untuk pH (r=0,856), pCO2 (r=0,814) dan kuat untuk pO2 (r=0,718) dan HCO3 (r=0,716) antara kedua alat. Tidak terdapat perbedaan yang bermakna antara hasil AGD arteri antara alat POCT dan BGA. Terdapat hubungan yang signifikan untuk semua parameter AGD arteri dengan korelasi sangat kuat. untuk pH, pCO2, dan korelsi kuat untuk pO2 dan HCO3 antara kedua alat. Kata Kunci: point of care testing, laboratory blood gas analyzer, analisis gas darah arteri, pneumonia
Effect of Vitamin D3 Supplementation on Hepcidin and Ferritin Levels in Children with CKD Rachmayani, Andi Muldiana Dwi; Aras, Jusli; Rauf, Syarifuddin; Lawang, Aizah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2455

Abstract

Chronic Kidney Disease (CKD), as a worldwide health concern, results in several complications. Anemia caused by erythropoietin deficiency, reduced iron absorption, and abnormalities in vitamin D metabolism are frequently seen in children with CKD. Ferritin is the body's iron storage, whereas hepcidin is a protein that impacts iron metabolism. Low vitamin D levels exacerbate heme deficiency and anemia. This study aimed to know the effect of vitamin D3 supplementation on serum hepcidin and ferritin levels in children with CKD. A prospective cohort design was conducted in Dr. Wahidin Sudirohusodo Hospital from July 2023 to April 2024. Samples were divided into two groups based on GFR. Complete blood count, vitamin D, ferritin, and hepcidin level examinations were performed before and after supplementation. The data was analyzed with the Mann-Whitney test. Forty-three children between the ages of 2 and 18 were involved in this study. There was no significant difference in the groups' age, gender, nutritional status, or diagnosis (p > 0.05). Ferritin levels significantly dropped in group II (p=0.002), hepcidin levels significantly dropped in all subjects (p < 0.001), and vitamin D levels increased significantly in both groups (p < 0.001) following supplementation. Vitamin D supplementation effectively increases vitamin D levels in children with CKD and significantly affects ferritin and hepcidin levels.
Co-Authors I Dewa Gede Ugrasena Idham Jaya Ganda, Idham Jaya Indrawati, Gracia Dewi Kardani, Astrid Kristina L, Amiruddin Lawang, Aizah Lawang, St. Aizah Mohammad Sjaifullah Noer Ninik Asmaningsih Soemyarso Rachmayani, Andi Muldiana Dwi Risky Vitria Prasetyo Syarifuddin Rauf