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All Journal Indonesian Journal of Urology Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Paediatrica Indonesiana Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Anesthesiology and Reanimation (IJAR) Majalah Biomorfologi (Biomorphology Journal) Green Medical Journal Indian Journal of Forensic Medicine & Toxicology

Ninik Asmaningsih Soemyarso

Department Of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital Surabaya, East Java

Author-ID : 3298359

Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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EVALUATION OF CAPD AS RENAL REPLACEMENT THERAPY IN CHILDREN Prasetyo, Risky Vitria; Ramadhani, Noershanti; Soemyarso, Ninik Asmaningsih; Noer, Mohammad Sjaifullah
Indonesian Journal of Urology Vol 19 No 2 (2012)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v19i2.57

Objective: To evaluate the outcome of pediatric patients treated with continuous ambulatory peritoneal dialysis (CAPD) performed by experienced pediatric urologists. Material & Method: A retrospective study of children with end-stage renal disease (ESRD) by peritoneal dialysis (PD) in Division of Nephrology Department of Child Health, Faculty of Medicine Airlangga University, Soetomo Hospital, Surabaya, from January 2003 to February 2012 was conducted. Children with acute kidney injury treated by PD were excluded.Data reviewed were age, sex, primary renal disease, age at start of CAPD, duration of CAPD, outcome and cause of death. Descriptive statistics were used to analyze the data.Results: Twenty seven cases of children with CAPD within 9-year period were included. Most patients were 11-15 years old with 62,9% being male. Chronic glomerulonephritis and nephrotic syndrome were the main primary renal diseases. Fifteen (55,6%) patients had peritonitis. The longest duration on CAPD was 53 months. Outcome of 27 children was as follows, 11 patients died (40,8%), 8 patients survived (29,6%), and another 8 were lost to follow-up (29,6%). All (100%) patients had cardiovascular abnormalities as cause of death. Conclusion: The outcome and mortality rate of children with CAPD remain unfavourable. This is a challenge still to be overcomed. Keywords: Continuous ambulatory peritoneal dialysis, children, outcome.

Role of Hepcidin in Pediatric Chronic Kidney Disease with Anemia Aras, Jusli; Kardani, Astrid Kristina; Soemaryo, Ninik Asmaningsih; Prasetyo, Risky Vitria; Noer, Mohammad Sjaifullah; Ugrasena, I Dewa Gede
Green Medical Journal Vol 3 No 3 December (2021): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v3i3.87

Introduction: Anemia is a frequent complication of chronic kidney disease (CKD) in children and it causes an increase in morbidity, mortality and accelerates the rate of progression of CKD. Inflammation and impaired kidney clearance increase plasma hepcidin, inhibiting duodenal iron absorption and sequestering iron in macrophages. However, the role of hepcidin in increasing the risk of anemia in children with CKD is still uncertain. This study aimed to investigate the association between hepcidin levels and anemia in children with pre-dialysis CKD. Methods: A cross-sectional study was conducted at Dr. Soetomo Academic Hospital from December 2018 to February 2019. Children with pre-dialysis CKD were enrolled in this study. The subject had no history of erythropoietin administration and blood transfusion 3 months before the blood sample were withdrawn. A complete blood count, ferritin serum, transferrin saturation (TSAT) and hepcidin serum were performed. The correlations between Hepcidin and ferritin level, between ferritin level and anemia, and between TSAT and anemia were analyzed using Spearman correlation and the Mann-Whitney test. Results: A total of 47 children, 27 boys and 20 girls, ranged in age from 3 months to 18 years old. There was a significant correlation between hepcidin and ferritin levels (p=0.006) and the value of the Spearman correlation was r=0.392. While the correlation between ferritin level and anemia showed a significant result, p=0.001. However, TSAT did not show any significant correlation with anemia (p=0.230). Conclusion: There was an indirect association between hepcidin level and anemia by increasing ferritin level that induces anemia in pre-dialysis CKD children.

The Correlation of Congenital Anomalies of The Kidney and Urinary Tract with Renal Function in Children Chairunnisa; Ninik Asmaningsih Soemyarso; Risky Vitria Prasetyo
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14692

Background: Congenital Anomalies Kidney and Urinary Tract (CAKUT) are the leading cause of kidneyfailure in children and cause of 30-40% end-stage renal disease with obstructive uropathy as the main cause.CAKUT obstructive type are: vesico uretric junction obstruction (VUJO), pelvic uretric junction obstruction(PUJO), posterior uretral valve (PUV) and non-obstructive type are reflux, neurogenic and hypoplasia. Theaim of this study is to describe the effect of CAKUT on renal function in child.Methods: Retrospective study from medical records of children with CAKUT at Dr. Soetomo GeneralHospital, Surabaya, Indonesia from January 2013 - March 2018. The characteristic of sex, age range, type ofCAKUT and glomerulus filtration (GFR) value were recorded from medical record. Data processing usingdescriptive analysis with SPSS.Result: A total of 94 Children on CAKUT abnormalities, both boys and girl’s presentation equal 50%.Median age 3.0 (minimum-maximum 1.0-15.0) year. The most common CAKUT type in male were VUJO17 (36.2%) and in female neurogenic type 19 (40.4%). Median initial glomerular filtration rate 2.7 ml/min/1.73 m2. Analysis of correlation between CAKUT and renal function p=0.072 (R2=0,03). From 94children of CAKUT, only 12 (12.8%) patients have undergo surgical intervention.Conclusion: CAKUT with dominant obstructive type was more common in male and non-obstructive typein female pediatric patient. There was no significance correlation of GFR between obstructive and nonobstructive type.

Fibroblast Growth Factor 23 in Children with Chronic Kidney Disease Muhammad Riza Kurniawan; Risky Vitria Prasetyo; Ninik Asmaningsih Soemyarso; Mohammad Sjaifullah Noer
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14821

Background: Decreased of glomerular filtration rate in chronic kidney disease (CKD) changes the calciumand phosphate balance. High phosphate levels in children with CKD stimulate secretion of FibroblastGrowth Factor 23 (FGF23). High FGF23 levels have harmful that potentially increase the morbidity andmortality of children with CKD.Objective: To analyze the level of FGF23 in children with CKD.Methods: A cross sectional study was performed in Pediatric Nephrology Ward and Outpatient Clinic ofDr. Soetomo General Hospital Surabaya, during December 2019-March 2020 for children with CKD stage1-5, aged 3 months to 18 years old. Children on phosphate-binder, vitamin D therapy, or severely ill wereexcluded. Blood level of FGF23 was measured using ELISA with statistic analysis with SPSS 20.Results: A total of 52 CKD stage 1-5 children were involved, mean age was 11.44 years old, and 50% wereboys. There were 51% children have FGF23 level more than 30 pg/ml. The lowest mean of FGF23 levelswas found in the CKD grade 1 (8.94 ± 8.77 pg/mL) and the highest mean at CKD grade 5 (113.30 ± 78.73pg/mL).Conclusion: The FGF23 level increasing accordance with increasing in the grade of CKD

Analysis of High Dose and Long-Term Prednisone Therapy on Trap 5B Level Change in Children with Steroid Sensitive Nephrotic Syndrome Dessy Surya Setyani; Mariyatul Qibtiyah; Ninik Asmaningsih; Yulistiani Yulistiani
Folia Medica Indonesiana Vol. 54 No. 2 (2018): June
Publisher : Faculty of Medicine, Universitas Airlangga

Nephrotic syndrome is a condition which is characterized by protein leakage from the blood to the urine through glomeruli. It leads to hypoproteinemia and generalised oedema. Patients with nephrotic syndrome need high dose and long term glucocorticoid such as prednisone. High dose and long term glucocorticoid can increase bone resorption. Biological marker is a valuable tool to evaluate efficacy of therapy. TRAP 5B is a sensitive biological marker for bone resorption because it reflects the number of osteoclasts. TRAP 5B is not affected by renal dysfunction and food. It also has a low diurnal variation than other bone resorption marker. The aim of this study was to analyze the changes of TRAP 5B levels at induction and alternate phase in children with steroid sensitive nephrotic syndrome. This observational prospective study was conducted from May to October 2016. Venous blood samples obtained at 08.00-10.00 am. TRAP5B levels were measured before and after induction phase and after alternate phase using ELISA. Fifteen patients were included in this study (60% boys). Majority of their age was 6 - <12 years and 40% were dependent steroid NS. TRAP 5B serum levels in induction phase increased by 37.41%±56.22%. In alternate phase, TRAP 5B serum levels increased by 28.75%±66.55% compared to the induction phase. However, the level change of both phases were not significant. As a conclusion, TRAP 5B levels increased in induction and alternate phase after high dose and long-term prednisone treatment in nephrotic syndrome.

Validity of Urine Syndecan-1 as A Predictor of Acute Kidney Injury In Pediatric Sepsis Patients Bambang Pujo Semedi; Arie Utariani; Nugroho Setia Budi; Ninik Asmaningsih; Lucky Andriyanto
Indonesian Journal of Anesthesiology and Reanimation Vol. 3 No. 2 (2021): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Introduction: AKI (Acute Kidney Injury) complications in sepsis patients generally occur 24 hours after admission to ICU. Creatine Serum Concentration is a standard parameter to diagnose AKI. Unfortunately, the changes in creatine serum concentration will only be seen several days after the decrease of renal function to 50%. The low detection ability has been linked with time loss before preventive therapy is commenced. Furthermore, this instigates the need for biomarkers to ensure early detection. Objective: This study aimed to identify cut-off points of urine syndecan-1 and to measure the prediction ability of urine syndecan-1 towards the AKI occurrence in pediatric sepsis patients. Materials and methods: This study was a prospective cohort study performed at a single center in Dr. Soetomo General Hospital, Surabaya. The inclusion criterion was all children admitted to the resuscitation room from October until December 2019. Furthermore, urine sampling is carried out at 0, 6, 12, and 24 hours for a syndecan-1 urine examination, and every procedure performed on the patient will be recorded. This action was continued up to the third day and aimed to evaluate some factors related to AKI at 48-72 hours of admission. Result and Discussion: Out of 41 pediatric sepsis patients, 30 patients fulfilled the inclusion criteria and 57% had AKI. The value of urine syndecan-1 at hour-0 and hour-6 was significantly featured a cut-off point. Conclusion: The value of urine syndecan-1 at hour-0 and hour-6 are valid parameters to predict the occurrence of AKI grades 1, 2, and 3 in pediatric septic patients at 48-72 hours after their hospital admission. The best cut-off value of urine syndecan-1 at the 0th hour was 0.67 ng/ml.

Correlation Between Nutritional Status Of Children Aged 12 – 36 Months And Mother’s Working Status In Taman, Sidoarjo Nur Annisa Nugraheningtyasari; Ninik Asmaningsih Soemayarso; Dwi Susanti
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: The correlation between child’s nutritional status and mother’s working status in Indonesia is still unclear. Some research report a high prevalence of low-nourished children whose mother is working, while others report a non significant correlation between child’s nutritional status and mother’s working status.Methods: This study was case-control study, sample of low-nourished children (treatment group) & well-nourished children (control) are taken from 21 Posyandu in Taman, Sidoarjo in 2015. All data were analyzed using Chi Square test.Results: There are 72 samples which are suitable with the inclusion criteria, consisted of 36 low-nourished children and 36 well-nourished children. From 72 samples, 28 children have a working mother and 44 children have a non working mother. There were no correlation between Mother’s working status (p=0,486), Number of children in the family (p=0,468), History of chronic disease (p=0,054) with child’s nutritional status. Level of family income, Mother’s education level, History of exclusive breastfeeding, Energy consumption level, Protein consumption level were correlated with child’s nutritional status with value (p=0,000), (p=0,002), (p=0,002), (p=0,000), (p=0,001) respectively.Conclusion: Mother’s working status is proved that is not correlated with child’s nutritional status. But, level of family income, mother’s education level, energy & protein consumption level, and history of exclusive breastfeeding are significantly correlated with child’s nutritional status.

Management of Lowe syndrome: a case report Risky Vitria Prasetyo; Heru Setiawan; Ninik Asmaningsih Soemyarso; Mohammad Sjaifullah Noer; Irwanto Irwanto; Prastiya Indra Gunawan; Rozalina Loebis; Sri Andreani Utomo; Ni Wayan Tirthaningsih
Paediatrica Indonesiana Vol 55 No 3 (2015): May 2015
Publisher : Indonesian Pediatric Society

Lowe syndrome (the oculocerebrorenal syndrome of Lowe, OCRL) is a multisystem disorder characterized by anomalies affecting the eyes, nervous system and kidneys.1-3 The disorder was first recognized by Lowe et al. in 1952, and described as a unique syndrome with organic aciduria, decreased renal ammonia production, hydrophthalmos, and mental retardation. In 1954, renal Fanconi syndrome was recognized as being associated with Lowe syndrome and in 1965, a recessive X-linked pattern of inheritance was determined.2,4 Lowe syndrome is a very rare disease, with an estimated prevalence in the general population of 1 in 500,000. According to the Lowe Syndrome Association (LSA) in the USA, the estimated prevalence is between 1 and 10 affected males in 1,000,000 people, with 190 living in the year 2000. The Italian Association of Lowe Syndrome estimated that there were 34 Lowe syndrome patients (33 boys and one girl) living in Italy in the year 2005.2,4,5 It almost exclusively affects males.6 Physicians may not be familiar with Lowe syndrome due to its rarity.4

Risk factors for hypertensive crisis in children with acute glomerulonephritis Sherly Yuniarchan; Risky Vitria Prasetyo; Ninik Asmaningsih Soemyarso; Mohammad Sjaifullah Noer
Paediatrica Indonesiana Vol 56 No 2 (2016): March 2016
Publisher : Indonesian Pediatric Society

Background Hypertensive crisis occurs in 1-4% of the hypertensive pediatric population, mostly due to acute glomerulonephritis (AGN). Some factors have been suggested to affect blood pressure (BP) in children, such as age, sex, race/ethnicity, obesity, and socioeconomic status, but little is known for risk factors for hypertensive crisis in AGN.Objective To analyze the risk factors for hypertensive crisis in children with AGN.Methods Retrospectively, we studied possible risk factors for hypertensive crisis in children with AGN at Dr. Soetomo Hospital from 2007 to 2011. Hypertensive crisis was defined as systolic BP â‰¥180 mmHg or diastolic BP â‰¥120 mmHg (for children â‰¥ 6 years of age); and systolic and/or diastolic BP >50% above the 95th percentile (for children aged <6 years). We evaluated the demographic and clinical characteristics as potential risk factors. Statistical analysis was done with Chi-square, Fisherâ€™s exact, and logistic regression tests. Variables with P <0.25 in the univariable analysis were further analyzed by the multivariable logistic regression model. A P value of < 0.05 was considered statistically significant.Results There were 101 children included (mean age 9.7 (SD 2.17) years), with a male-to-female ratio of 2.7:1. Hypertensive crisis occurred in 42 (41.6%) children, of whom 8 had hypertensive urgency and 34 had hypertensive emergency. Proteinuria was seen in 53 children with AGN (52.5%) and was the significant risk factor for hypertensive crisis in our subjects (OR=2.75; 95%CI 1.16 to 6.52; P=0.021). Gender, clinical profiles, ethnicity, nutritional status, blood urea nitrogen (BUN), and glomerular filtration rate (GFR) were not significant risk factors for hypertensive crisis.Conclusion Proteinuria is the significant risk factor for hypertensive crisis in children with AGN.

Persistent proteinuria as an indicator of renal disease in HIV-infected children Yuni Hisbiiyah; Risky Vitria Prasetyo; Dwiyanti Puspitasari; Ninik Asmaningsih Soemyarso; Ismoedijanto Moedjito; Mohammad Sjaifullah Noer
Paediatrica Indonesiana Vol 56 No 6 (2016): November 2016
Publisher : Indonesian Pediatric Society

Background Persistent proteinuria (microalbuminuria) has been reported to be a precursor of HIV-related renal disease. Screening allows for early management in order to prevent the progression of renal disease and decrease morbidity and mortality associated with chronic kidney disease in HIV. Several studies have been done on renal manifestation in HIV-infected children from American and African regions, but similar studies from Asia are lacking.Objective To determine the prevalence of persistent proteinuria in HIV-positive children on antiretroviral therapy (ARV) in Dr. Soetomo Hospital, Surabaya.Methods A cross-sectional study on children with HIV and treated with Â highly active antiretroviral therapy (HARRT) was done from August 2014 to February 2015. Microalbuminuria was measured by the ratio of urine albumin to creatinine (ACR), while proteinuria was measured by dipstick. Measurements were performed 3 times in 4-8 weeks. All subjects underwent complete evaluation of blood tests, serum creatinine, blood urea nitrogen (BUN), CD4 counts, and urinalysis. Data were analyzed using Chi-square and logistic regression tests.Results Of 38 children on HARRT enrolled in this study, 2 subjects developed acute kidney injury (AKI), 4 subjects were suspected to have urinary tract infection (UTI), and 1 subject was suspected to have urinary tract stones. The prevalence of persistent microalbuminuria was 2.6%. There was no correlation between immunological status, WHO clinical stage, or duration of ARV and the incidence of persistent proteinuria (P>0.05).Conclusion The prevalence of persistent proteinuria is Â lower in younger HIV-infected children at a non-advanced stage and HIV-infected children with normal immunological status who are on HAART. We provide baseline data on the renal conditions of HIV-infected children in the era of HAART, before tenovofir is Â increasingly used as an antiretroviral therapy regimen in Indonesia.

Co-Authors Aras, Jusli Aras, Jusli Aras Atika Atika Chairunnisa Dessy Surya Setyani Dewi Ratna Sari Dwi Susanti Dwiyanti Puspitasari, Dwiyanti Esthy Poespitaningtyas Hanindita, Meta Herdiana Heru Setiawan I Dewa Gede Ugrasena Irwanto, Irwanto Ismoedijanto Jusak Nugraha Kardani, Astrid Kristina Lucky Andriyanto Lukman Oktadianto Lutifta Hilwana Mariyatul Qibtiyah Mohammad Sjaifullah Noer Muhammad Riza Kurniawan Ni Wayan Tirthaningsih Noershanti Ramadhani Nugroho Setia Budi Nur Annisa Nugraheningtyasari Paul L Tahalele Prastiya Indra Gunawan Putu Dian Saraswati Riskky Vitria Prasetyo Risky Vitria Prasetyo Roedi Irawan Rozalina Loebis Semedi, Bambang Pujo Sherly Yuniarchan Shidi Laras Pramudito Sri Andreani Utomo Utariani, Arie Windhu Poernomo Yulistiani Yulistiani Yuni Hisbiiyah

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