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All Journal JCPS (Journal of Current Pharmaceutical Sciences)
Irfan Zamzani
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Medicine & Pharmacology

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Activity of N-Hexane, Ethyl Acetate and Methanol Extracts from Passiflora foetida Leaves as α-Glucosidase Enzyme Inhibitor Nita Triadisti; Irfan Zamzani
JCPS (Journal of Current Pharmaceutical Sciences) Vol 4 No 2 (2021): March 2021
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

Diabetes mellitus is a major health problem characterized by an increase in postprandial blood glucose levels, where α-glucosidase enzyme inhibitors are an effective therapeutic option. The limited choice of α-glucosidase enzyme inhibitors has triggered a study to obtain new α-glucosidase inhibitor candidates. Kelubut (Passiflora foetida) has been used for generations in the treatment of diabetes in Kalimantan, usually the roots and leaves are part of the plant used in the treatment of diabetes. Scientific data regarding α-glucosidase inhibition have not been reported. The extraction was carried out using the multilevel maceration method, while the α-glucosidase inhibition test was carried out by the spectrophotometric method using a microplate reader. The assay results showed that all extracts had inhibitory activity against α-glucosidase, and the best activity was the methanol extract of Passiflora foetida leaves with IC50 580.04 µg / mL
The Effect of Concentration of NaOH and H2SO4 on Isolation and Identification of Cellulose Using The Delignification Process of Water Hyacinth Powder (Eichhornia crassipes) Yulianita Pratiwi Indah Lestari; Nita Triadisti; Irfan Zamzani
JCPS (Journal of Current Pharmaceutical Sciences) Vol 5 No 1 (2021): September 2021
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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The effect of concentration of NaOH and H2SO4 in cellulose isolation by delignification process from water hyacinth powder has been investigated to reduce lignin content. Delignification was carried out at 121⁰C for 30 minutes with variations in NaOH concentration being 0%, 2.5%, 5.0%, 7.5%, and 10% (w/v), while the variation of H2SO4: 0% , 0.5%, 1.0%, 1.5%, and 2.0% (v/v). The decrease in lignin content was analyzed based on the remaining cellulose content. The increase in the concentration of NaOH and H2SO4 was in line with the decrease in the amount of cellulose obtained. The biggest decrease was in NaOH 10% with cellulose yield of 32,66% and H2SO4 2.0% with cellulose yield of 42,00%.
REVIEW : PENGEMBANGAN SISTEM PENGHANTARAN BERBASIS NANOPARTIKEL DALAM SEDIAAN KOSMESETIKA HERBAL Risa Ahdyani; Sri Rahayu; Irfan Zamzani; Andika Andika
JCPS (Journal of Current Pharmaceutical Sciences) Vol 4 No 1 (2020): September 2020
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

Herbal cosmeceuticals are cosmetic-pharmaceutical hybrids intended to enhance health and beauty through natural ingredients that are applied onto skin surface. The ability of an ingredient in enhancing skin's biological texture and function depends on the delivery system to reach specific targeted sites in an amount sufficient to exert an effect in a controlled manner. The novel approach that could be used in the delivery of herbal cosmeceuticals is nanoparticle-based delivery system. Many researches have been conducted on the development of nanoparticle-based delivery system containing natural ingredients such as gotu kala extract, rosemary extract, orange peel extract, ginseng extract, basil extract, safflower extract, resveratrol, and Taduvelai extract. Based on the literature study of previous researches reported that nanoparticle-based delivery system has been successfully delivered those natural ingredients through certain mechanism in enhancing activity as skin antiaging, skin whitening, antiacne, and hair care product.
Co-Authors Andika Andika Risa Ahdyani Sri Rahayu Triadisti, Nita Yulianita Pratiwi Indah Lestari