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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan JCPS (Journal of Current Pharmaceutical Sciences) Journal of Innovation Research and Knowledge Proceeding ISETH (International Summit on Science, Technology, and Humanity) Borneo Journal of Pharmacy Jurnal Riset Multidisiplin Edukasi
Triadisti, Nita
Universitas Muhammadiyah Banjarmasin
Humanities Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences Other

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Limpasu Pericarpium : an Alternative Source of Antioxidant From Borneo with Sequential Maceration Method Irfan Zamzani; Nita Triadisti
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i1.2820

Abstract

Antioxidants are substances that can slow down the oxidation process of free radicals. Limpasu plant (Baccaurea lanceolata (Miq) Muell. Arg), an indigenous plant of Borneo, is a natural antioxidant source. The purpose of this study was to determine the antioxidant activity of the limpasu pericarpium extract. The extraction of the limpasu pericarpium was done by maceration method using solvents with increasing polarity ranging from n-hexane, ethyl acetate, and methanol. Antioxidant activities of the three extracts were measured by the DPPH and FRAP methods. The IC50 values of n-hexane, ethyl acetate, and methanol extracts, as well as quercetin using the DPPH method were 517,45 µg/mL, 530,64 µg/mL, 10,63 µg/mL and 6,83 µg/mL, respectively. Meanwhile, the IC50 values obtained from FRAP method were 198,96 µg/mL, 190,07 µg/mL, 661,36 µg/mL, and 7,09 µg/mL, respectively. The results revealed that the methanol extract is more potent than other extracts tested for antioxidant activity.
Activity of N-Hexane, Ethyl Acetate and Methanol Extracts from Passiflora foetida Leaves as α-Glucosidase Enzyme Inhibitor Nita Triadisti; Irfan Zamzani
JCPS (Journal of Current Pharmaceutical Sciences) Vol 4 No 2 (2021): March 2021
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

Diabetes mellitus is a major health problem characterized by an increase in postprandial blood glucose levels, where α-glucosidase enzyme inhibitors are an effective therapeutic option. The limited choice of α-glucosidase enzyme inhibitors has triggered a study to obtain new α-glucosidase inhibitor candidates. Kelubut (Passiflora foetida) has been used for generations in the treatment of diabetes in Kalimantan, usually the roots and leaves are part of the plant used in the treatment of diabetes. Scientific data regarding α-glucosidase inhibition have not been reported. The extraction was carried out using the multilevel maceration method, while the α-glucosidase inhibition test was carried out by the spectrophotometric method using a microplate reader. The assay results showed that all extracts had inhibitory activity against α-glucosidase, and the best activity was the methanol extract of Passiflora foetida leaves with IC50 580.04 µg / mL
The Effect of Concentration of NaOH and H2SO4 on Isolation and Identification of Cellulose Using The Delignification Process of Water Hyacinth Powder (Eichhornia crassipes) Yulianita Pratiwi Indah Lestari; Nita Triadisti; Irfan Zamzani
JCPS (Journal of Current Pharmaceutical Sciences) Vol 5 No 1 (2021): September 2021
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

The effect of concentration of NaOH and H2SO4 in cellulose isolation by delignification process from water hyacinth powder has been investigated to reduce lignin content. Delignification was carried out at 121⁰C for 30 minutes with variations in NaOH concentration being 0%, 2.5%, 5.0%, 7.5%, and 10% (w/v), while the variation of H2SO4: 0% , 0.5%, 1.0%, 1.5%, and 2.0% (v/v). The decrease in lignin content was analyzed based on the remaining cellulose content. The increase in the concentration of NaOH and H2SO4 was in line with the decrease in the amount of cellulose obtained. The biggest decrease was in NaOH 10% with cellulose yield of 32,66% and H2SO4 2.0% with cellulose yield of 42,00%.
ANALISA KUALITATIF SILDENAFIL SITRAT PADA BEBERAPA PRODUK JAMU SEHAT PRIA DENGAN METODE KROMATOGRAFI LAPIS TIPIS DI WILAYAH BANJARMASIN Nita Triadisti; Heldawati Heldawati
JCPS (Journal of Current Pharmaceutical Sciences) Vol 1 No 2 (2018): March 2018
Publisher : LPPM - Universitas Muhammadiyah Banjarmasin

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Abstract

Jamu merupakan budaya Indonesia yang selama ini digunakan masyarakat Indonesia untuk menjaga kesehatan dan merawat kecantikan. Adanya jamu dengan kandungan bahan kimia obat (BKO), memperburuk citra jamu sebagai budaya Indonesia. Salah satu BKO yang disertakan dalam jamu, baik jamu kemasan maupun jamu seduh adalah sildenafil sitrat. Studi ini bertujuan untuk identifikasi kandungan bahan kimia obat sildenafil sitrat dalam jamu seduh sehat pria, menggunakan metode kromatografi lapistipis (KLT). Analisis kualitatif dilakukan menggunakan kromatografi lapis tipis dengan fasa gerak : etil asetat : metanol : amonia (85:10:5). Hasil analisis menunjukkan bahwa dari 13 sampel jamu seduh sehat pria, 5 sampel diantaranya positif mengandung bahan kimia obat sildenafil sitrat.
Column Chromatography Fractionation and Antioxidant Activity of Passiflora foetida Leaves Nita Triadisti; Irfan Zamzani
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.1830

Abstract

Available synthetic antioxidants have been reported to have mutagenic and toxic effects. On the other hand, natural antioxidants show their superiority as they are not or less toxic. Passiflora foetida has the potential as an antioxidant, but the investigation of the antioxidant activity of the P. foetida chromatography column fraction has not been reported. This studied aims to investigate the antioxidant activity of the column chromatographic fractions of P. foetida leaves. An antioxidant assay using the DPPH and FRAP methods. The extraction was carried out by graded maceration, then fractionation using column chromatography. The antioxidant activity test was carried out using the DPPH and FRAP methods. Thin Layer Chromatography analysis was performed to determine the chromatogram pattern. The EC50 using DPPH method from n-hexane extract: 129.035 µg/mL, ethyl acetate extract: 206.398 µg/mL, methanol extract: 97.453 µg/mL, while the EC50 using FRAP method from n-hexane extract: 67.851 µg/mL, ethyl acetate extract : 68.981 µg/mL, and methanol extract: 58.787 µg/mL. Column chromatography fractions have antioxidant activity, with FMetPF6 as the fraction with the best activity, with percent inhibition 41.85±1.96 at concentration 25 µg/mL (DPPH), and with percent antioxidant activity 26.03±0.84 at concentration 9 µg/mL (FRAP). Passiflora foetida leaves have great potential as an antioxidant; both the extract and its fractions have antioxidant activity. The FMetPF6 has the best activity compare to other extracts and fractions. Further analysis to determine the various compounds in FMetPF6 using LC-MS/MS will facilitate the active compound's isolation.
Literature Review : Skrining Fitokimia Pada Berbagai Tanaman Obat Sebagai Sumber Senyawa Bioaktif Nadia Safitri; Riska Hidayah; Nita Triadisti
Jurnal Riset Multidisiplin Edukasi Vol. 2 No. 7 (2025): Jurnal Riset Multidisiplin Edukasi (Edisi Juli 2025)
Publisher : PT. Hasba Edukasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71282/jurmie.v2i7.773

Abstract

Phytochemical screening is a crucial preliminary step in identifying secondary metabolites from medicinal plants that serve as potential bioactive compounds for the development of traditional and modern medicines. This review summarizes findings from 25 national and international journals that investigated various plant sources, including leaves, flowers, seeds, fruits, stems, and even microalgae. The most commonly analyzed compounds include flavonoids, alkaloids, tannins, saponins, steroids, triterpenoids, polyphenols, glycosides, and anthraquinones. The results indicate that flavonoids and tannins are the most frequently detected metabolites, both of which are known for their antioxidant, antimicrobial, anti-inflammatory, and wound-healing properties. Variations in metabolite content among plants are influenced by species, plant parts used, extraction methods, and the choice of solvents, with ethanol being the predominant solvent. Several studies also complemented the screening with biological activity assays, such as DPPH antioxidant testing, antibacterial assays, and wound-healing studies, further supporting the therapeutic potential of these compounds. This review highlights the importance of phytochemical screening as a scientific foundation for the development of phytopharmaceuticals and the utilization of Indonesia’s rich biodiversity.
DIABETES MELLITUS TIPE 2: PATOFISIOLOGI MOLEKULER SERTA EFEKTIVITAS PERAN ANTIOKSIDAN, PENGHAMBAT Α-GLUKOSIDASE DAN DIPEPTIDIL PEPTIDASE-4 Nita Triadisti
Journal of Innovation Research and Knowledge Vol. 5 No. 3: Agustus 2025
Publisher : Bajang Institute

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Abstract

Diabetes mellitus merupakan salah satu permasalahan kesehatan global dengan angka kejadian global diabetes yang terus meningkat dari waktu ke waktu. Angka ini diperkirakan akan terus meningkat mencapai 643 juta dan 783 juta di tahun 2030 dan 2045. Review ini bertujuan mendeskripsikan patofisiologi diabetes mellitus yang berfokus pada defisiensi dan resistensi insulin, termasuk uraian mekanisme molekulernya. Pembahasan juga disertai keterkaitan enzim α-glukosidase, hormon inkretin dan enzim dipeptidil peptidase-4 pada progres diabetes mellitus tipe 2, yang dilengkapi mekanisme molekulernya. Review ini juga meninjau peran kelas terapi penghambat enzim α-glukosidase, dan dipeptidil peptidase-4 disertai potensi peran antioksidan dalam mengatasi progres diabetes mellitus tipe 2. Review artikel ini disusun menggunakan penelusuran literatur, dengan berbagai kata kunci sesuai dengan pembahasan, dengan kriteria jurnal dari tahun 2020 – 2025 yang diharapkan dapat menjadi landasan ilmiah yang kuat dalam pembahasan sehingga memberikan pemahaman yang komprehensif. Review ini menunjukkan peran penting dari antioksidan, penghambat α-glukosidase dan enzim dipeptidil peptidase-4 dalam mengatasi diabetes mellitus tipe 2, dimana antioksidan membantu mengurangi stres oksidatif yang berkontribusi pada kerusakan sel dan komplikasi terkait diabetes, penghambat α-glukosidase memperlambat penyerapan karbohidrat di saluran pencernaan, dan penghambat DPP-4 meningkatkan kadar inkretin, yang merangsang pelepasan insulin sehingga membantu pengendalian gula darah secara lebih efektif. Kombinasi tindakan ini dapat memperbaiki kontrol glikemik dan mengurangi risiko komplikasi diabetes.
Antibacterial Activity of Extract and Fraction of Baccaurea macrocarpa Leaf on Escherichia coli and Bacillus cereus Zamzani, Irfan; Triadisti, Nita
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1426

Abstract

Purpose: The purpose of the present study is to investigate antibacterial activity of extract and fraction of Baccaurea macrocarpa leaf, and to identify secondary metabolite contents of the best activity.Methodology: Baccaurea macrocarpa leaf was extracted by using maceration method with the use of methanol solvent. The extract was then fractionated by adopting n-hexane and ethyl acetate by using liquid-liquid extraction. Antibacterial activity assay was performed by using inhibition zone assay particularly Disc Diffusion Susceptibility method from methanol extract and fraction extract of ethyl acetate and n-hexane. Phytochemical screening as the best activity was performed by using by adopting Thin Layer Chromatography (TLC). Result: Antibacterial activity was identified in the ethyl acetate extract of Baccaurea macrocarpa leaf. In addition, secondary metabolites with the best activity such as alkaloid, anthraquinone, flavonoid, and tannin were identifiable in the fraction extract of ethyl acetate of Baccaurea macrocarpa.
Co-Authors Heldawati Heldawati Irfan Zamzani Irfan Zamzani Nadia Safitri Riska Hidayah Yulianita Pratiwi Indah Lestari Zamzani, Irfan Zamzani, Irfan