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All Journal Hemera Zoa Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Pengabdian Mandiri
Sayu Putu Yuni Paryati
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Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences Veterinary Other

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Journal : Hemera Zoa

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PCS-6 Preparation and Application of Nano Chitosan Particles as Adjuvan in Rabies Vaccination Based on Anti-Idiotype Antibody Sayu Putu Yuni Paryati; K Hasan; S Ramadhanti
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

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Abstract

Rabies is a fatal disease to humans and animals, but can be controlled by prophylaxis administration before being exposed. One type of vaccine that can be utilized is an anti-idiotype antibody vaccine originating from IgY purification of chicken egg yolk. The use of vaccine additives in the form of adjuvants is very important to improve the effectiveness of vaccines [1].Chitosan is non-toxic, easily synthesized, safe to use and able to induce an immune response by activating macrophages. Chitosan can modulate dendritic cell maturation so that it can induce interferon interactions and stimulate activity of T lymphocytes and B lymphocytes. Chitosan can be made in the form of chitosan nanoparticles that can be used to deliver drugs and vaccines through inhalation pathways, orally, intravenously and as non-viral gene delivery vectors. In the oral delivery of chitosan nanoparticles are able to overcome the problem of solubility, protect the drug from enzymatic degradation, controlled release, and extend the time of action in the bloodstream through ionic mechanisms with mucin. Inhalation of chitosan 0.5mg/ml with influenza vaccine produces a good response [2-4].In this work, the preparation of chitosan nanostructures and their application as adjuvan in antibody anti-idiotype rabies vaccination were reviewed.
VPH-4 The Influence of Medium pH on Lactobacillus acidophillus Viability in Soyghurt Tested In Vitro and In Vivo Lia Siti Halimah; Sayu Putu Yuni Paryati; Eka Noneng Nawangsih
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

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Abstract

L. acidophillus bacteria have a high tolerance for acidic atmosphere. This bacterial resistance occurs because the ability to maintain cytoplasmic pH is more alkaline than extracellular pH so that all the different proteins and enzymes in it can still work optimally. L. acidophillus bacteria have cell membranes that are more resistant to cell leakage. Cellular membranes consisting of two layers of phospholipid (lipid bilayer) which on each surface of the layer are attached to proteins and lipid bilayer glycoproteins are semipermeable, which will limit the movement of compounds in and out between the cytoplasm and the external environment. The digestive tract has a different pH, starting from the oral cavity with a pH ranging from 6-7 (interval), stomach with pH 1.5-2 (acid), and intestine with a pH of 8-8.9 (base). Many bacteria can live and have habitat in the oral and intestinal cavities, but only certain bacteria are known to survive in the stomach. The nature of bacteria, in general, does not stand in an acidic atmosphere in the stomach, but there are also pathogenic bacteria (detrimental) that are resistant to the acidic atmosphere in the stomach so that it can cause disease in the digestive system. The stomach is an organ of the digestive system which functions to digest food and as the body's defense organ. The body's defense mechanism is carried out by the stomach against bacteria, namely by removing stomach acid. The presence and endurance of L. acidophillus bacteria in the stomach have not been reported. Therefore, in this study will be tested the effect of soyghurt containing L. acidophillus bacteria on the viability of L. acidophillus bacteria in the stomach and its effect on the gastric fluid profile of male Wistar rats.
Co-Authors Anastasia Yani T Apen Afgani Aria Rachmatullah Awan Buana Dandi Fery Gunawan Eka Noneng Nawangsih Elizabeth Noviana Lumban Raja Henny Juliastuti K Hasan LIA SITI HALIMAH Panca Andana S Ramadhanti Siska Telly Pratiwi