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Velaro, Adrian Joshua
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Humanities Computer Science & IT Economics, Econometrics & Finance Education Social Sciences

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The Effect of Cranberry (Vaccinium macrocarpon) Fruit Extract on VEGF Levels in Wistar Rats (Rattus norvegicus) with Cystitis Model Az, Muhammad Nur Hidayah; Nasution, Muhammad Andriady Saidi; Budi, Andre; Velaro, Adrian Joshua
Journal of Social Research Vol. 4 No. 12 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i12.2897

Abstract

Cystitis, often caused by Escherichia coli, triggers inflammation and tissue damage in the bladder. While the anti-adhesion properties of cranberry (Vaccinium macrocarpon) against uropathogenic bacteria are well known, its role in the subsequent healing phase, particularly through modulation of Vascular Endothelial Growth Factor (VEGF), remains poorly understood. This study aims to investigate the effect of cranberry fruit extract on VEGF levels and the degree of histopathological inflammation in a cystitis model. Fosfomycin trometamol is an effective antibiotic for treating urinary tract infections, particularly bacterial cystitis. However, the observed increase in Vascular Endothelial Growth Factor (VEGF) levels during treatment is not a direct effect of the drug but rather a biological response associated with the body’s natural healing process. In cystitis, inflammation and tissue damage in the bladder wall trigger the release of various cytokines and chemokines, including VEGF, which plays a key role in angiogenesis and tissue regeneration. Fosfomycin works by reducing bacterial load and inflammation, thereby allowing the body to enter the active healing phase. During this phase, increased VEGF levels reflect ongoing tissue repair and new blood vessel formation. Therefore, the elevation of VEGF should be interpreted not as a side effect of fosfomycin but as a biological marker of bladder tissue recovery following successful infection clearance.
Effect of Cranberry Fruit Extract (Vaccinium Macrocarpon) on Vegf Value in Wistar (Rattus Norvegicus) Mouse Pyelonephritis Model Putri, Desika Aura; Saidi Nasution, Muhammad Andriady; Budi, Andre; Velaro, Adrian Joshua
Journal of Social Research Vol. 4 No. 12 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i12.2904

Abstract

This study aimed to investigate the effect of cranberry extract on Vascular Endothelial Growth Factor (VEGF) levels and renal histopathological improvement in a rat model of pyelonephritis. Seven treatment groups were used, including a sham group, a negative control, a positive control (ciprofloxacin), and cranberry extract groups at doses of 100, 200, 300, and 400 mg/kgBW. Data were analyzed using the Kruskal–Wallis test followed by an all-pairwise comparison. The results showed a significant difference in VEGF levels among the groups (p = 0.046), with notably higher VEGF expression in the 300 mg/kgBW and 400 mg/kgBW cranberry groups compared to the negative control. Histopathological analysis revealed reduced inflammatory cell infiltration and improved tubular structure in the high-dose cranberry groups. These effects are associated with the bioactive compounds of cranberry, particularly proanthocyanidins and flavonoids, which exhibit anti-inflammatory, antioxidant, and angiogenic activities by enhancing VEGF expression. In conclusion, cranberry extract at doses of 300 mg/kgBW and 400 mg/kgBW demonstrates strong potential as a natural nephroprotective agent that accelerates renal tissue healing in pyelonephritis. These findings support the use of cranberry extract as an adjuvant therapy to complement conventional treatment for urinary tract infections
Co-Authors Az, Muhammad Nur Hidayah Budi, Andre Nasution, Muhammad Andriady Saidi Putri, Desika Aura Saidi Nasution, Muhammad Andriady