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All Journal Journal Orthopaedi and Traumatology Surabaya (JOINTS) Journal of Social Research
Velaro, Adrian Joshua
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Humanities Computer Science & IT Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Social Sciences

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The Effect of Cranberry (Vaccinium macrocarpon) Fruit Extract on VEGF Levels in Wistar Rats (Rattus norvegicus) with Cystitis Model Az, Muhammad Nur Hidayah; Nasution, Muhammad Andriady Saidi; Budi, Andre; Velaro, Adrian Joshua
Journal of Social Research Vol. 4 No. 12 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i12.2897

Abstract

Cystitis, often caused by Escherichia coli, triggers inflammation and tissue damage in the bladder. While the anti-adhesion properties of cranberry (Vaccinium macrocarpon) against uropathogenic bacteria are well known, its role in the subsequent healing phase, particularly through modulation of Vascular Endothelial Growth Factor (VEGF), remains poorly understood. This study aims to investigate the effect of cranberry fruit extract on VEGF levels and the degree of histopathological inflammation in a cystitis model. Fosfomycin trometamol is an effective antibiotic for treating urinary tract infections, particularly bacterial cystitis. However, the observed increase in Vascular Endothelial Growth Factor (VEGF) levels during treatment is not a direct effect of the drug but rather a biological response associated with the body’s natural healing process. In cystitis, inflammation and tissue damage in the bladder wall trigger the release of various cytokines and chemokines, including VEGF, which plays a key role in angiogenesis and tissue regeneration. Fosfomycin works by reducing bacterial load and inflammation, thereby allowing the body to enter the active healing phase. During this phase, increased VEGF levels reflect ongoing tissue repair and new blood vessel formation. Therefore, the elevation of VEGF should be interpreted not as a side effect of fosfomycin but as a biological marker of bladder tissue recovery following successful infection clearance.
Effect of Cranberry Fruit Extract (Vaccinium Macrocarpon) on Vegf Value in Wistar (Rattus Norvegicus) Mouse Pyelonephritis Model Putri, Desika Aura; Saidi Nasution, Muhammad Andriady; Budi, Andre; Velaro, Adrian Joshua
Journal of Social Research Vol. 4 No. 12 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i12.2904

Abstract

This study aimed to investigate the effect of cranberry extract on Vascular Endothelial Growth Factor (VEGF) levels and renal histopathological improvement in a rat model of pyelonephritis. Seven treatment groups were used, including a sham group, a negative control, a positive control (ciprofloxacin), and cranberry extract groups at doses of 100, 200, 300, and 400 mg/kgBW. Data were analyzed using the Kruskal–Wallis test followed by an all-pairwise comparison. The results showed a significant difference in VEGF levels among the groups (p = 0.046), with notably higher VEGF expression in the 300 mg/kgBW and 400 mg/kgBW cranberry groups compared to the negative control. Histopathological analysis revealed reduced inflammatory cell infiltration and improved tubular structure in the high-dose cranberry groups. These effects are associated with the bioactive compounds of cranberry, particularly proanthocyanidins and flavonoids, which exhibit anti-inflammatory, antioxidant, and angiogenic activities by enhancing VEGF expression. In conclusion, cranberry extract at doses of 300 mg/kgBW and 400 mg/kgBW demonstrates strong potential as a natural nephroprotective agent that accelerates renal tissue healing in pyelonephritis. These findings support the use of cranberry extract as an adjuvant therapy to complement conventional treatment for urinary tract infections
Predictive Factors for Plate Failure After Humeral Fracture Fixation: A Two-Trauma Center Study Nasution, Nino; Nasution, Alif Aditya; Velaro, Adrian Joshua; Tobing, Bagas; Putra, Benny Hosiana; Morteza, Muhammad; Zidane, Sayyid Muhammad; Al Kahfi Nasution, Habib; Pandelima, Maksum
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 15 No. 1 (2026): April 2026
Publisher : Universitas Airlangga

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Abstract

Background: Plate fixation is commonly used for humeral fractures, yet plate failure remains a serious complication that can delay union and impair function. This study aimed to identify factors associated with humeral plate failure in two trauma centers.Methods: A retrospective review of electronic medical records from two trauma centers in Medan, Indonesia was performed. Extracted variables included patient demographics, fracture location and pattern, plate type and material, time to clinical union, smoking status, and neurovascular complications. Comparative analyses between failure and non-failure groups were conducted using independent t-tests or Mann–Whitney tests for numerical variables and chi-square or Fisher’s exact tests for categorical variables. Statistical significance was set at p < 0.05.Results: Thirty-one patients were included, and 5 (16.1%) experienced plate failure. No significant differences were found for sex (p = 0.231), age (p = 0.614), or body mass index (p = 0.379). Plate failure was not significantly associated with fracture location (p = 0.175), fracture pattern (p = 1.000), plate material (p = 1.000), time to clinical union (p = 0.525), or plate type (p = 0.700). Smoking (p = 0.020) and neurovascular damage were significantly associated with plate failure (p = 0.008).Conclusions: In this cohort, smoking and neurovascular injury were significantly associated with an increased risk of humeral plate failure. Perioperative identification and management of neurovascular compromise, along with smoking cessation strategies, may reduce the risk of implant failure. Further studies with larger samples are warranted.
Co-Authors Al Kahfi Nasution, Habib Az, Muhammad Nur Hidayah Budi, Andre Morteza, Muhammad Nasution, Alif Aditya Nasution, Muhammad Andriady Saidi Nasution, Nino Pandelima, Maksum Putra, Benny Hosiana Putri, Desika Aura Saidi Nasution, Muhammad Andriady Tobing, Bagas Zidane, Sayyid Muhammad