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Detection of glibenclamide adulteration in herbal remedies for diabetes mellitus using TLC Budi, Andre; Razoki, Razoki; Harahap, Halimah; Amansyah, Adek; Edlin, Edlin; Tarigan, Susiani
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5287

The widespread use of jamu, a traditional Indonesian herbal medicine, has been accompanied by a surge in adulteration with synthetic drugs to enhance efficacy and sales. This study aimed to detect the presence of glibenclamide, a common adulterant, in antidiabetic jamu product using TLC. This study employed three herbal medicine samples marketed for lowering blood glucose levels, with glibenclamide BPFI serving as a reference standard. Thin-layer chromatography, employing a mobile phase consisting of chloroform, cyclohexane, ethanol, and glacial acetic acid (9:9:1:1), was utilized for the analysis. Thin-layer chromatography (TLC) analysis revealed a standard Rf value of 0.4 for glibenclamide, producing a distinct blue-violet spot when visualized with 10% sulfuric acid. The results indicated that the tested herbal medicine samples did not contain the pharmaceutical substance glibenclamide. This conclusion was drawn from the absence of a corresponding Rf value for glibenclamide in the herbal samples when compared to the reference standard.

Screening of polypharmacy prescriptions in hypertensive patients at Royal Prima Hospital Nasution, Nanda Rahma Dewi; Budi, Andre; Lubis, Razoki; Sari, Nila
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5288

Hypertension occurs when a person's blood pressure exceeds the normal limits. This results in increased morbidity and mortality. The method in this study is descriptive, with the use of retrospective research, where the study was conducted by reviewing information or retrieving data that had existed before. Data were collected through polypharmacy prescriptions for patients with high blood pressure at the Royal Prima Medan Hospital between September and November 2023, with 650 prescriptions collected. From the results of this study, the prescriptions that met the inclusion criteria were 100% in accordance with the symptoms, drug doses, mechanisms, procedures, and duration of drug use. A total of 26 prescriptions contained five drugs with 63.41% interaction out of a total of 41 prescriptions. A total of 34 prescriptions contained 6 drugs, with 65.11% of the total 49 prescriptions. A total of 19 prescriptions contained seven drugs, with 82.61% of the total 23 prescriptions. A total of 13 prescriptions containing 8 drugs with a percentage of interactions of 86.67% of the total 15 prescriptions. Most interactions occurred in six prescriptions containing nine drugs, with 100% interaction from a total of six drugs. Most interactions also occurred in four prescriptions containing 10 drugs, with 100% interaction from a total of four drugs.

Effectiveness of durian peel ethanol extract for lowering blood sugar levels in alloxan diabetic wistar rats Budi, Andre; Nababan, Samuel Maringan Tua; Nardi, Leo
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4523

High blood sugar levels can be influenced by several factors, including high-carbohydrate food consumption and a lack of physical activity. To minimize the side effects of hyperglycemic treatment, efforts have been made to explore anti-hyperglycemic compounds from other sources, such as durian peel (Durio zibetthinus Murr.). This study aimed to determine the effectiveness of ethanol extract from durian peel in lowering alloxan-induced blood sugar levels in Wistar rats (Rattus novergicus). The study is an experimental research employing an alloxan-induced diabetic rat model. The rats were divided into five different groups: Group I (negative control), Group II (positive control), Group III (dose 25 × 10–30/gBW), Group IV (dose 50 × 10–30/gBW), and Group V (dose 100 × 10–30/gBW). The durian peel used in this study was extracted using the maceration method with ethanol as the solvent. The results of this study indicate that ethanol extract from durian peel significantly reduced blood sugar levels after 10 to 15 days of durian peel extract administration (p < 0.05).

The Effect of Giving Butterfly Pea Flower Extract (Clitoria ternatea) on Reducing Cholesterol Levels and Histopathological Features of White Rat Testes (Rattus norvegicus) Wistar Male Obesity Model Jaya, Risnaldo; Budi, Andre; Sihombing, Bungaran
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 2 (2024): May 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.319

Obesity is a global, non-communicable condition that causes male infertility. Obesity impacts spermatogenesis and male fertility. Butterfly pea blossoms (Clitoria ternatea) contain antioxidants that fight free radicals and prevent obesity. This research looked at how butterfly pea flower extract (Clitoria ternatea) affected cholesterol levels, testicular function, and the histopathology of the testicles of obese male Wistar rats (Rattus norvegicus). This research is quantitative and uses a lab or actual experiment. The 24 test mice were randomly divided into four groups. The research data was analyzed using SPSS 25.0 for Windows. The normality test significance is 0.577. One-way ANOVA test results demonstrate 0.000 or greater than 0.05 significance. LSD post-hoc test values. The control and treatment groups 1–3 differed significantly (p = 0.000). No change was seen between treatment groups 2 and 3 (p = 0.088). The research found butterfly pea flower extract therapy (Clitoria ternatea) at 400mg and 600 mg/kgBW lowers cholesterol. Flavonoids, saponins, tannins, and triterpenoids reduce cholesterol and improve testicular function in obese white rats.

HUBUNGAN KEBIASAAN KONSUMSI KOPI TERHADAP TEKANAN DARAH PADA MAHASISWA/I FAKULTAS KEDOKTERAN UNIVERSITAS PRIMA INDONESIA ANGKATAN 21 Vialenthyna, Hindyra; Delfian, Taufik; Budi, Andre
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.35654

Kafein merupakan methylxanthine utama yang terdapat dalam kopi dan perannya yang signifikan adalah meningkatkan tekanan darah. Kafein dalam kopi dapat menghambat reseptor adenosine dan menghambat fosfodiesterase, sehingga dapat meningkatkan tekanan darah. Adenosin, yang bertindak sebagai vasodilator dan mengatur tekanan darah, diyakini terpengaruh oleh kafein dalam mekanisme regulasi tekanan darah setelah mengonsumsi kopi. Mahasiswa kedokteran cenderung mengonsumsi kafein sebagai stimulan karena jadwal istirahat yang terbatas, Motivasi di balik konsumsi kafein oleh mahasiswa disebabkan oleh peningkatan fungsi kognitif setelah mengonsumsi kafein, termasuk peningkatan konsentrasi, daya ingat, dan performa fisik. Tujuan dari penelitian ini adalah untuk mengetahui hubungan kebiasaan konsumsi kopi pada mahasiswa dan apakah ada peningkatannya pada tekanan darah mahasiswa/i angkatan 21 kedokteran UNPRI. Penelitian ini menerapkan desain observasi analitik dengan pendekatan cross-sectional dalam pengumpulan data. Variabel independen pada penelitian ini adalah kebiasaan mengonsumsi kopi, sedangkan variabel dependen pada penelitian ini adalah tekanan darah. Populasi yang yang digunakan dalam penelitian ini mahasiswa Fakultas Kedokteran Universitas Prima Indonesia Angkatan 21. Metode sampling yang diterapkan dalam penelitian ini yaitu consecutive sampling. Pada hasil penelitian menunjukkan bahwa dari 56 responden yang dianalisis, sebagian besar (34 orang) memiliki kebiasaan konsumsi kopi dalam kategori sedang, dengan mayoritas (36 orang) memiliki tekanan darah yang normal. Hasil uji bivariat menunjukkan nilai p sebesar 0,621 (>0,05), yang mengindikasikan bahwa tidak ada hubungan signifikan antara kebiasaan konsumsi kopi dan tekanan darah di antara responden yang diteliti.

Hubungan Indeks Massa Tubuh dan Jenis Kelamin Terhadap Kelenturan Tubuh Pada Mahasiswa Fakultas Kedokteran Universitas Prima Indonesia Cenggana , Juflin Lipputri; Budi, Andre; Delfian, Taufik
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.33645

Tingkat kelenturan tubuh seseorang secara langsung memengaruhi kualitas gerakan yang mereka hasilkan. Latihan diperlukan untuk meningkatkan kelenturan otot untuk mencapai kelenturan yang maksimal. Fleksibilitas tubuh seseorang dipengaruhi oleh sejumlah faktor internal, termasuk usia, jenis kelamin, anatomi sendi, tendon, dan tonus otot. Tujuan dari penelitian ini adalah untuk menyelidiki korelasi potensial antara fleksibilitas tubuh seseorang dengan jenis kelamin dan indeks massa tubuh. Dengan jumlah sampel sebanyak 60 orang, populasi penelitian ini terdiri dari mahasiswa kedokteran semester enam dari Universitas Prima Indonesia. Teknik pengambilan sampel yang digunakan adalah non-probability sampling yang dikombinasikan dengan strategi purposive sampling. Teknik uji korelasi Spearman adalah strategi pengujian yang digunakan dalam penelitian ini. Temuan penelitian menunjukkan bahwa tidak ada korelasi antara fleksibilitas tubuh dan indeks massa tubuh karena indeks massa tubuh tidak dapat menilai komposisi tubuh seseorang secara keseluruhan, yang mencakup massa otot dan kandungan lemak. Namun, jenis kelamin memang berdampak pada fleksibilitas tubuh karena pria cenderung lebih aktif secara fisik daripada wanita.

The relationship between stress levels and sleep quality on blood pressure among medical student Hafizhah, Dhea; Delfian, Taufik; Budi, Andre
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.5866

Hypertension, often termed a "silent killer" due to its asymptomatic nature, is a chronic condition that significantly elevates the risk of cardiovascular mortality. This cross-sectional study aimed to investigate the correlation between perceived stress levels, sleep quality, and blood pressure among medical students at Universitas Prima Indonesia in class 2021. This study used a cross-sectional observational design. A purposive sample of 56 medical students was recruited based on the predefined inclusion and exclusion criteria. Data were collected using the Perceived Stress Scale-10 (PSS-10) to assess stress levels, Pittsburgh Sleep Quality Index (PSQI) to evaluate sleep quality, and a digital sphygmomanometer to measure blood pressure. The findings revealed that the majority of respondents (75%) reported moderate stress levels, 66.1% had poor sleep quality, and 82.1% exhibited normal blood pressure. These results suggest a correlation between perceived stress, sleep quality, and blood pressure among medical students at Universitas Prima Indonesia, Class 2021.

Description of Characteristics of Typhoid Fever Sufferers in Children Aged 5-14 Years at RSU Royal Prima Medan for the Period August 2022-February 2023 Dhawy Dermawan, Dzaky; Fadillah, Qori; Budi, Andre
Jurnal Multidisiplin Indonesia Vol. 3 No. 1 (2024): Jurnal Multidisiplin Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jmi.v3i1.1007

Infectious diseases are still a public health problem, especially in developing countries. One of the infectious diseases is typhoid fever. Typhoid fever is an acute infection of the small intestine with symptoms of fever lasting more than one week, which can cause digestive disorders and reduce the level of consciousness. This research aims to analyze the characteristics of typhoid fever sufferers in children aged 5-14 years at RSU Royal Prima Medan from August 2022 - February 2023. The type of research used in this research is a qualitative description with a cross-sectional design. The population used was 46 medical records of typhoid fever sufferers in children aged 5-14 years at RSU Royal Prima Medan from August 2022 - February 2023. The sampling technique used in this research used total sampling, while the number of samples used was 46 records. Medical treatment for typhoid fever patients. Data analysis uses univariate analysis. The results of the study showed that the number of typhoid fever sufferers in children aged 5-14 years at RSU Royal Prima Medan from August 2022 – February 2023 was 46 children, 27 of the sufferers were predominantly male while 19 were female. All typhoid fever sufferers in this study experienced accompanying symptoms of fever, nausea, vomiting, and diarrhea; only five typhoid fever sufferers, or 10.9%, were accompanied by additional accompanying symptoms in the form of abdominal pain. Normal body weight in male patients was 19 patients, and abnormal body weight was eight patients. Normal body weight in female patients was eight patients, and abnormal body weight was 11 patients. All typhoid fever sufferers received RL and NaCL therapy, only 11 sufferers received additional Cefixime therapy, and only 32 sufferers received additional Cefriaxone therapy. August 2022 – February 2023 is > 3 days.

Detection of glibenclamide adulteration in herbal remedies for diabetes mellitus using TLC Budi, Andre; Razoki, Razoki; Harahap, Halimah; Amansyah, Adek; Edlin, Edlin; Tarigan, Susiani
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5287

The widespread use of jamu, a traditional Indonesian herbal medicine, has been accompanied by a surge in adulteration with synthetic drugs to enhance efficacy and sales. This study aimed to detect the presence of glibenclamide, a common adulterant, in antidiabetic jamu product using TLC. This study employed three herbal medicine samples marketed for lowering blood glucose levels, with glibenclamide BPFI serving as a reference standard. Thin-layer chromatography, employing a mobile phase consisting of chloroform, cyclohexane, ethanol, and glacial acetic acid (9:9:1:1), was utilized for the analysis. Thin-layer chromatography (TLC) analysis revealed a standard Rf value of 0.4 for glibenclamide, producing a distinct blue-violet spot when visualized with 10% sulfuric acid. The results indicated that the tested herbal medicine samples did not contain the pharmaceutical substance glibenclamide. This conclusion was drawn from the absence of a corresponding Rf value for glibenclamide in the herbal samples when compared to the reference standard.

Screening of polypharmacy prescriptions in hypertensive patients at Royal Prima Hospital Nasution, Nanda Rahma Dewi; Budi, Andre; Lubis, Razoki; Sari, Nila
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5288

Hypertension occurs when a person's blood pressure exceeds the normal limits. This results in increased morbidity and mortality. The method in this study is descriptive, with the use of retrospective research, where the study was conducted by reviewing information or retrieving data that had existed before. Data were collected through polypharmacy prescriptions for patients with high blood pressure at the Royal Prima Medan Hospital between September and November 2023, with 650 prescriptions collected. From the results of this study, the prescriptions that met the inclusion criteria were 100% in accordance with the symptoms, drug doses, mechanisms, procedures, and duration of drug use. A total of 26 prescriptions contained five drugs with 63.41% interaction out of a total of 41 prescriptions. A total of 34 prescriptions contained 6 drugs, with 65.11% of the total 49 prescriptions. A total of 19 prescriptions contained seven drugs, with 82.61% of the total 23 prescriptions. A total of 13 prescriptions containing 8 drugs with a percentage of interactions of 86.67% of the total 15 prescriptions. Most interactions occurred in six prescriptions containing nine drugs, with 100% interaction from a total of six drugs. Most interactions also occurred in four prescriptions containing 10 drugs, with 100% interaction from a total of four drugs.

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