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In Silico Prediction of Potential Compounds of Nigella sativa as Aromatase Agonists and Ability to Cross the Blood-Brain Barrier for treatment of Alzheimer’s Disease Kusuma Andriana; Nurdiana; Wisnu Barlianto; I Wayan Arsana Wiayasa; Masruroh Rahayu
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14321

Background: Alzheimer’s disease (AD), is a chronic neurodegenerative disease which condition ischaracterized by a decline in memory, thinking skills, and the ability to perform basic activities of dailyliving. Study showed that postmenopausal women with AD had a lower aromatase activity (p450 aromatase)in the brain compared to menopausal women without AD. To improve cognitive function in AD patients,Nigella sativa (NS) was found to have a protective effect on memory, and cognitive function. This studytherefore, aimed to investigate in silico prediction of potential compounds of Nigella sativa as aromataseagonists and ability to cross the Blood-Brain Barrier (BBB) for treatment of Alzheimer’s Disease. Methods:The data sets used in this study were collected from databases KnapSack Kanaya, PubChem, and PASSserver Way2Drug. HitPick and Autodock Vina was performed. Additionally, the systematic analysisinvolved ADMET, LMMD, and SWISS ADME. Results and Discussions: In silico test results revealed themost promising constituents in 36 active NS compounds that may have potential to reduce the severity ofthe AD, owing to its anti-inflammatory, cytochrome p450 stimulants, free radical scavengers, antioxidants,and immunomodulators. The ability of NS to cross the BBB was proven by admetSAR LMMD with ananalysis average value of 0.91 (from the highest value of 1). Further, NS can trigger cytochrome P450aromatase activity via Quercetin 3-(6’’ ‘’-feruloylglucosyl)-(1->2)-galactosyl-(1->2)-glucoside which has abetter binding affinity value than its control (androstenedione). NS through oleic acid compounds may bindto peroxisome proliferator-activated receptor gamma (PPRAG), similar to Rosiglitazone which may affecttranscription and activation regulation of PPARG. Conclusion: To be concluded, Nigella sativa could beused as a potential medicinal plant for the treatment of Alzheimer’s disease.

PENGARUH TERAPI FAMILY PSYCHOEDUCATION (FPE) TERHADAP KECEMASAN DAN BEBAN KELUARGA DALAM MERAWAT ANGGOTA KELUARGA DENGAN SKIZOFRENIA DI KECAMATAN BOLA KABUPATEN SIKKA, NUSA TENGGARA TIMUR Adelheid Riswanti Herminsih; Wisnu Barlianto; Rinik Eko Kapti
Jurnal Kesehatan Mesencephalon Vol 3, No 2 (2017): Jurnal Kesehatan Mesencephalon - Oktober 2017
Publisher : Sekolah Tinggi Ilmu Kesehatan Kepanjen

Abstract : Schizophrenia is a disease process that affects perceptions, emotions, social behavior and the ability to accept reality correctly. Families with schizophrenics often feel anxiety and burdens associated with client care. The problem can be solved by giving FPE therapy. This study aims to explain the effect of Family Psychoeducation (FPE) therapy on anxiety and family burden in caring for family members with schizophrenia. This research uses quasi experiment research pre-post test with control group. The number of respondents in this study were 18 respondents for the control group and 18 respondents for the treatment group. The study was conducted in District Bola from 24 May to 28 June 2017. Giving therapy done by the researchers themselves who have obtained a license from nurse specializing in mental health nursing. Data analysis used in this research is dependent t test and independent t test. The result of dependent t test of anxiety and load test was obtained significance value <0,05, this result showed significant decrease of anxiety and load after FPE therapy. While the results of independent t test showed that the significance of anxiety and family burden <0.05 which means that there is a significant difference in reducing anxiety and family burden between the treatment and control group after being given FPE therapy, that is, with an average decrease in anxiety and burden For the treatment and control groups of 10.11 and 3.5, respectively. This means that FPE is more effective in reducing family anxiety. Thus it is expected that FPE can be applied as an alternative therapy in reducing the anxiety of families who care for people with schizophrenia.Keywords : family psychoeducation, anxiety, family burden Abstrak : Skizofrenia merupakan proses penyakit yang mempengaruhi persepsi, emosi, perilaku sosial dan kemampuan menerima realita dengan benar. Keluarga dengan penderita skizofrenia seringkali merasakan kecemasan dan beban yang berkaitan dengan perawatan klien. Masalah tersebut dapat diatasi dengan pemberian terapi FPE. Penlitian ini bertujuan menjelaskan pengaruh terapi Family Psychoeducation (FPE) terhadap kecemasan dan beban keluarga dalam merawat anggota keluarga dengan skizofrenia. Penelitian ini menggunakan desain penelitian quasi experiment pre-post test with control group. Jumlah responden dalam penelitian ini 18 responden untuk kelompok kontrol dan 18 responden untuk kelompok perlakuan. Penelitian dilakukan di Kecamatan Bola mulai tanggal 24 Mei-28 Juni 2017. Pemberian terapi dilakukan oleh peneliti sendiri yang telah mendapatkan lisensi dari perawat spesialis jiwa. Analisis data yang digunakan dalam penelitian ini adalah dependent t test dan independen t test. Hasil analisis dependent t test kecemasan dan beban didapatkan nilai signifikansi< 0,05, hasil ini menunjukkan penurunan kecemasan dan beban secara bermakna setelah diberikan terapi FPE. Sedangkan hasil analisis independent t test menunjukkan bahwa nilai signifikansi kecemasan dan beban keluarga < 0,05 yang berarti bahwa ada perbedaan yang bermakna dalam menurunkan kecemasan dan beban kelurga antara kelompok perlakuan dan kontrol setelah diberikan terapi FPE, yaitu dengan rata-rata penurunan kecemasan dan beban untuk kelompok perlakuan dan kontrol masing-masing yakni 10,11 dan 3,5. Hal ini berarti bahwa FPE lebih efektif dalam menurunkan kecemasan keluarga. Dengan demikian diharapkan bahwa FPE bisa diaplikasikan sebagai alternative terapi dalam menurunkan kecemasan keluarga yang merawat penderita skizofrenia.Kata Kunci : family psychoeducation, kecemasan, beban keluarga

EFEKTIFITAS PENGARUH SOCIAL SKILL TRAINING DALAM MENURUNKAN PERILAKU ISOLASI SOSIAL REMAJA KORBAN BULLYING DI SMK AHMAD YANI PROBOLINGGO Rizka Yunita; Wisnu Barlianto; Rinik Eko Kapti
Jurnal Kesehatan Mesencephalon Vol 3, No 2 (2017): Jurnal Kesehatan Mesencephalon - Oktober 2017
Publisher : Sekolah Tinggi Ilmu Kesehatan Kepanjen

Abstract : Bullying is common especially when entering adolescence. However, if bullying is done continuously causes the negative impact such as anxiety, shame, low confidence, and anxiety. Those impacts encourage them to isolate themselves from the social environment. An effort that can be done to handle the situation is to provide Social Skill Training. This therapy teaches social skills through basic communication techniques, verbal and non-verbal, to express their thoughts and feelings well. The purpose of this research is to analyze the effectivity of SST on the decrease of social isolation behavior among teenagers who become the victims of bullying. This research uses quasy experimental with pre post-test design. The technique to determine the sample is using purposive sampling in the class X students who experienced social isolation behavior due to bullying. The total sample used was 18 respondents. According to univariate test, the result got that social isolation behavior score before given SST equal to 79,11 while after given SST equal to 58,83. Whereas, paired t-test showed that there were differences of social isolation behavior score before and after given SST intervention which had significant value equal to ρ = 0,000. This research hopes that there will be interventions given to families, schools and peers through supportive therapy in order to provide support to the bullying teens.Keywords : SST, social isolation behavior, bullying Abstrak : Bullying saat ini marak terjadi terutama saat memasuki usia remaja. Apabilabullying dilakukan terus menerus dapat menimbulkan kecemasan, malu, menurunkan kepercayaan diri, dan gelisah sehingga mendorong mereka untuk mengisolasi diri dari lingkungan sosial. Salah satu upaya yang dapat dilakukan untuk menangani situasi tersebut adalah memberikanSocial Skill Training. SST mengajarkan keterampilan sosial melalui teknik komunikasi dasar secara verbal dan non verbal sehingga mampu mengutarakan pikiran dan perasaannya dengan baik. Tujuan penelitian ini adalah menganalisis efektifitas pengaruh SST dalam menurunkan perilaku isolasi sosial remaja korban bullying.Penelitian ini menggunakan desain quasyexperimental dengan pre-post testdesign. Teknik penentuan sampel menggunakan purposive sampling pada siswa kelas X yang mengalami perilaku isolasi sosial akibat bullying. Total sampel yang digunakan sebanyak 18 responden. Berdasarkan hasil uji univariat didapatkan bahwa skor perilaku isolasi sosial sebelum diberikan SST sebesar 79,11 sedangkan sesudah diberikan SST sebesar 58,83. Sementara itu, hasil uji t-test berpasangan menunjukkan bahwa terdapat perbedaan skor perilaku isolasi sosial sebelum dan sesudah diberikan intervensi SST mempunyai nilai signifikansi sebesar ρ=0,000.Hal ini berarti bahwa intervensi SST signifikan menurunkan perilaku isolasi sosial. Penelitian ini mengharapkan terdapat pemberian intervensi kepada keluarga, sekolah, dan teman sebaya melalui terapi suportif sehingga dapat memberikan dukungan kepada remaja korban bullying didalam menurunkan perilaku isolasi sosial.Kata kunci: SST, Perilaku Isolasi Sosial, Bullying

ASSOCIATION BETWEEN AEROALLERGEN SENSITIZATION AND THE SEVERITY OF ASTHMA IN PEDIATRIC PATIENTS Vivin Detriana; Agung Prasetyo Wibowo; Muchammad Fahrul Udin; Ery Olivianto; Wisnu Barlianto; HMS. Chandra Chandra
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Asthma is one of the most common chronic diseasesin childhood, with increasing prevalence in the past3 decades (Nievas et al, 2013). The prevalence ofasthma in the world is approximately 7.2% (6%adults and 10% children).There are variations in the prevalence and mortalityof asthma. WHO estimates that there are currently250,000 deaths due to asthma. It is leading cause ofchildhood hospitalization and school absenteeism.Asthma is more prevalent in boys in the first years oflife, but in adolescents it predominates amongfemale subjects. Asthma affects minority and lowincomegroups disproportionately (Herzog et al,2011; Rahajoe, 2013).In Indonesia, Asthma is the top ten causes ofmorbidity and mortality. The study data ofhousehold health survey in 1986 in various provincesin Indonesia showed asthma ranks 5th of 10thcauses of morbidity. In 1992 Household HealthSurvey, asthma, chronic bronchitis and emphysemaas 4th cause of death in Indonesia (5.6%). In 1995,the prevalence of asthma in Indonesia approximately13/1000, compared with chronic bronchitis is11/1000 and pulmonary obstruction is 2/1000(Guidelines for Diagnosis and Management ofAsthma In Indonesia, 2013)Asthma is a heterogeneous disorder in children thatis characterized by recurrent airway obstruction,bronchial hyper-responsiveness, and airwayinflammation. (Herzo et al, 2011).The pathophysiologic basis of asthma is not wellunderstood. It appears to have a complex,multifactorial etiology which results from aninterplay of many hereditary factors and a numberof environmental factors. Bronchial biopsies frompatients with even mild asthma have evidence ofchronic inflammation, and cytokines and othermediators of inflammation are found in bronchialwashings from asthma patients. Some families aremore prone to development of allergies, and there isa well-known association between allergies andasthma. This suggests a genetic predisposition, but itappears that a number of genes are involved.Proceeding ICMHS 2016 ISBN 978-602-60569-3-1127Figure 1. Pathophysiology of astmaSource: Busse W. & Lemanske R: N. Engl. J. Med.2001;344(5):350-362Asthma attacks is vary from mild to severe and lifethreatening. The various factors which can triggerasthma attacks, such as exercise, allergens,infections, sudden changes in air temperature, orexposure to respiratory irritants such as cigarettesmoke and others. (Rahajoe, 2013)Aeroallergen sensitization is a risk factor in thedevelopment of childhood asthma. Aeroallergensensitization occurs in most patients with asthmaand is noted in a high percentage of patients withmild and moderate asthma. The percentage of thosethat are atopic with severe asthma appears less, butstill approximates the percent seen in patients withmild and moderate asthma. The most commonlyimplicated allergens are house dust mite (HDM),cockroach, and furred animals. Aeroallergensensitization can be evaluated using skin testing. (Rajet al, 2013)House dust mites are arachnids that are microscopicin size (~0.33mm long). They are found in dust andproducts with woven material or stuffing such asmattresses, pillows, stuffed animals, and bedding.Their life cycle from egg to adult takes 3 to 4 weeksand they live for 6 to 8 weeks. Females produce 40to 80 eggs during this time.It has been shown that dust mite exposure in earlychildhood is an important determinant in asthmadevelopment. Sporik et al. showed that 16 of 17children with asthma were sensitized to dust mite.urther, the higher the level of dust mite exposure at1 year old, the earlier the first episode of wheezingoccurred. The relative risk of asthma was almost 5-times greater in the subjects who were exposed tohigh levels of dust mite allergen (>10 μg/g) (Baxi etal, 2010)They demonstrated that early exposure to housedust mite was associated with an increased risk ofasthma and late onset wheezing. They followed agroup of 440 children from birth to 7 years andfound that children exposed to high levels of dustmite allergen in their bed at 2 to 3 months old had a3-fold increase in the odds of asthma at age 7 yearsold compared with those exposed to low level dustmite allergen (Baxi et al, 2010)Skin prick testing (SPT) is an easy, cost-effective andconvenient approach to identify sensitization toallergens. SPT detects the presence of allergenspecific IgE bound to mast cells by eliciting mast celldegranulation to the specific allergen being tested(Raj et al, 2013).The purpose of this study was to determine theassociation of aeroallergen sensitization and theseverity of asthma in pediatric patients.

ASSOCIATION BETWEEN IGE SERUM LEVEL AND SEVERITY OF ASTHMA IN CHILDREN Nindy Resti Rahayu; Agung Prasetyo Wibowo; Muchammad Fahrul Udin; Ery Olivianto; Wisnu Barlianto; HMS. Chandra Kusuma
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Asthma is an inflammatory chronic process involvingrespiratory tract wall and cause limited airflow withincreased of respiratory tract reactivity. It is arespiratory disease that is more common in children.Definition of asthma from Global Initiative Asthma(GINA), asthma is a heterogeneous disease, usuallymarked by chronic inflammation respiratory tract.Asthma causes symptoms such as wheezing,shortness of breath, chest tightness and cough thatvary over time, in their occurrence, frequency andintensity (GINA, 2016). International Consensus on(ICON) Pediatric Asthma, asthma is a chronicinflammation disorder which correlate withrespiratory tract obstruction that clinicalmanifestation wheezing, cough and shortness ofbreath (Rahajoe et al, 2015). Estimate prevalence ofasthma in the world is 7.2% (6% adults and 10%children) (Rahajoe, 2015).The pathogenesis, immunopathology, genetic,clinical manifestation, diagnosis and therapy forasthma had much progress. Therefore, it’s can’t besure which one comes first because the complexityof both factor (Rahajoe, 2015). In many case,especially children and young adult, asthma iscorrelated with manifestation of atopy in Ig-Edependentmechanism (Rahajoe, 2013). There wasno different of asthma mechanism in pediatric andadult. Although there was some problem in asthmapediatric there was not found in adult because of thepathology, lack of good scientific evidence,difficulties in determining of diagnosis and therapyand also variation of remodeling response of therapythat could not predicted before. This conditionespecially for children under five year old (Rahajoe,2015).In population, atopy factor give contribute 40%asthma patient pediatrics and adult. Atopy, thegenetic predisposition for the development of anImmunoglobulin E (IgE)-mediated response tocommon aeroallergens, is the strongest identifiablepredisposing factor for developing asthma (Rahajoe,2013). Asthma has an inheritable component to itsexpression, but the genetics involved in the eventualdevelopment of asthma (Ober, 2005). The role ofgenetics in IgE production, airwayhyperresponsiveness, and dysfunctional regulationof the generation of inflammatory mediators hasappropriately captured much attention. Asthma is aneffect from histamine in bronchial muscle. Histaminerelease together with IgE which mediated mast celldegranulation and make quickly contriction andbronchioles muscle spasm (Boyce, 2003). Ig Eattaches to cell surfaces via a specific high-affinityreceptor. The mast cell has large numbers of IgEreceptors; these, when activated by interaction withantigen, release a wide variety of mediators to iniateacute bronchospasm and also to release proinflammatorycytokines to perpetuade underlyingairway inflammation (Sporik, et al. 1995). Inlaboratory findings, pediatric patients with asthmashow increased IgE serum levels compared tonormal individuals without asthma. Ig E serum levelis specific for allergic status. It is useful to identifiedrisk factor or triggers of asthma. That is Ig Eresponsible for allergic attack (Rahajoe, 2013).However, lack of evidence of the associationbetween IgE serum levels and severity of asthma inchildren. This study aims to determine theassociation between IgE serum levels and severity ofasthma in children.

FAKTOR RISIKO KEGAWATAN NAFAS PADA NEONATUS DI RSD. DR. HARYOTO KABUPATEN LUMAJANG TAHUN 2013 Marfuah Marfuah; Wisnu Barlianto; Dian Susmarini
Journal of Nursing Science Update (JNSU) Vol. 1 No. 2 (2013)
Publisher : Department of Nursing, Faculty of Health Sciencce, Universitas Brawijaya

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Kegawatan nafas pada neonatus merupakan masalah yang dapat menyebabkan henti nafas bahkan kematian, sehingga dapat meningkatkan morbiditas dan mortalitas pada bayi baru lahir. Banyak faktor resiko kegawatan nafas neonatus baik faktor bayi, ibu, tali pusat, plasenta dan persalinan. Penelitian ini bertujuan untuk mencari faktor risiko yang berhubungan dengan kegawatan nafas neonatus. Penelitian dilakukan dengan desain penelitian case control dengan pendekatan retrospektif dari data rekam medis, buku register dan laporan harian ruang neonatus. Jumlah sampel 240 responden yang terbagi menjadi 120 kelompok kasus (gawat nafas) dan 120 kelompok kontrol (tidak gawat nafas) di ruang Neonatus RSD. Dr. Haryoto Kabupaten Lumajang. Kegawatan nafas neonatus berdasarkan data skor Downe dan faktor yang diteliti umur ibu, kehamilan ganda, derajat asfiksia, usia kehamilan, paritas, hipertensi pada ibu, jenis kelamin, berat badan lahir, jenis persalinan, partus lama, sindrom aspirasi meconium dan kadar gula darah acak ibu. Data dianalisis dengan uji Chi-square dilanjutkan regresi logistik. Hasil penelitian ini didapatkan derajat asfiksia, kehamilan ganda, usia kehamilan, paritas, dan hipertensi ibuÂ merupakan faktor risiko signifikan pada kegawatan nafas neonatus. Pada model regresi logistik, derajat asfikasi dan kehamilan ganda merupakan prediktor kuat terjadinya kegawatan nafas neonatus dan hipertensi pada ibu merupakan faktor proteksi yang menurunkan kegawatan nafas neonatus. Kata Kunci : Faktor Risiko, Kegawatan Nafas Neonatus

Increase in Serum Ferritin Level as a Marker of Disease Activity in Pediatric Sys-temic Lupus Erythematosus (pSLE) Patients: Serum Ferritin Level as a marker of disease activity in pSLE Desy Wulandari; Wisnu Barlianto; Susanto Nugroho; Tita Luthfia Sari
Journal of Tropical Life Science Vol. 13 No. 2 (2023)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.13.02.11

Ferritin is an acute-phase reactant that is elevated in autoimmune disorders, including systemic lupus erythematosus (SLE). However, their correlation withÂ disease activity scores has not been confirmed. Pandemic Covid-19 makes children visitation to hospital to get the treatment of SLE were delayed. This study aimed to evaluate correlation between serum ferritin and disease activity and its role in screening for flare in pediatric SLE (pSLE) patients during pandemic Covid-19. This is a cross-sectional study conducted in Saiful Anwar General Hospital Malang. Sampling was carried out sequentially on pediatric patients who met the criteria for Systemic Lupus International Collaborating Clinics (SLICC) and were recorded between July 2021-May 2022. All patients were interviewed and assessed for disease activity usingÂ SLE Disease Activity Index 2000 (SLEDAI-2k). A score <4 was categorized as inactive disease. Biochemical, serological tests including markers of disease activity and ferritin level were measured by standard laboratory procedure. Comparison, correlation and ROC curve analyses were performed with SPSS software. There were 38 females pSLE participated in this study. The mean age of the patients were 12.6â€¯Â±â€¯3.02â€¯years. Serum ferritin significantly higher in active disease compared to inactive disease 84.50 ng/mL (68.00-151.75 ng/mL) ng/mL and 815.00 ng/mL (451.25-1570.00 ng/mL), a value of p<0.05 was determined to be statistically significant. A significant correlation was found between serum ferritin with SLEDAI 2KÂ (râ€¯=â€¯0.890, pâ€¯=â€¯0.000). Correlation was also found between serum ferritin and IgM anti-double stranded-DNA (râ€¯=â€¯0.325, pâ€¯=â€¯0.046), but not with other laboratory and serological parameters. In ROC curve analysis, we found that Area Under The Curve (AUC) 0.989, 95%CI 0.964-1.014, p value 0,000, with cut off value 297.50 with sensitivity 85% and specificity 94.4%. Ferritin was increased in active disease Â Â as compared to inactive disease and correlated withÂ SLEDAIÂ score and IgM-dsDNA. Thus, ferritin may be potential as an affordable and available marker of disease activity in pSLE during pandemic Covid-19.

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