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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Pediatric Sciences Journal
Tita Luthfia Sari
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Agriculture, Biological Sciences & Forestry Environmental Science Health Professions Public Health

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Increase in Serum Ferritin Level as a Marker of Disease Activity in Pediatric Sys-temic Lupus Erythematosus (pSLE) Patients: Serum Ferritin Level as a marker of disease activity in pSLE Desy Wulandari; Wisnu Barlianto; Susanto Nugroho; Tita Luthfia Sari
Journal of Tropical Life Science Vol. 13 No. 2 (2023)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.13.02.11

Abstract

Ferritin is an acute-phase reactant that is elevated in autoimmune disorders, including systemic lupus erythematosus (SLE). However, their correlation with disease activity scores has not been confirmed. Pandemic Covid-19 makes children visitation to hospital to get the treatment of SLE were delayed. This study aimed to evaluate correlation between serum ferritin and disease activity and its role in screening for flare in pediatric SLE (pSLE) patients during pandemic Covid-19. This is a cross-sectional study conducted in Saiful Anwar General Hospital Malang. Sampling was carried out sequentially on pediatric patients who met the criteria for Systemic Lupus International Collaborating Clinics (SLICC) and were recorded between July 2021-May 2022. All patients were interviewed and assessed for disease activity using SLE Disease Activity Index 2000 (SLEDAI-2k). A score <4 was categorized as inactive disease. Biochemical, serological tests including markers of disease activity and ferritin level were measured by standard laboratory procedure. Comparison, correlation and ROC curve analyses were performed with SPSS software. There were 38 females pSLE participated in this study. The mean age of the patients were 12.6 ± 3.02 years. Serum ferritin significantly higher in active disease compared to inactive disease 84.50 ng/mL (68.00-151.75 ng/mL) ng/mL and 815.00 ng/mL (451.25-1570.00 ng/mL), a value of p<0.05 was determined to be statistically significant. A significant correlation was found between serum ferritin with SLEDAI 2K (r = 0.890, p = 0.000). Correlation was also found between serum ferritin and IgM anti-double stranded-DNA (r = 0.325, p = 0.046), but not with other laboratory and serological parameters. In ROC curve analysis, we found that Area Under The Curve (AUC) 0.989, 95%CI 0.964-1.014, p value 0,000, with cut off value 297.50 with sensitivity 85% and specificity 94.4%. Ferritin was increased in active disease   as compared to inactive disease and correlated with SLEDAI score and IgM-dsDNA. Thus, ferritin may be potential as an affordable and available marker of disease activity in pSLE during pandemic Covid-19.
A successful management of children with retroperitoneal abscess due to recurrent renal staghorn calculi Krisni Subandiyah; Astrid Kristina Kardani; Tita Luthfia Sari
Pediatric Sciences Journal Vol. 5 No. 1 (2024): (Available online: 1 June 2024)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v5i1.46

Abstract

Introduction: A particular kind of urolithiasis known as "staghorn calculi" occurs when the calculus grows into the pelvis and renal calyces. It was characterised by fast growth, which might progress to kidney damage and result in other consequences if left untreated. Although the disease's clinical presentation in paediatric patients might be non-specific, it still dramatically raises morbidity and death rates. This case report aimed to identify the risk factors, clinical manifestation, and treatment of children with retroperitoneal abscesses due to recurrent renal calculi. Case description: We describe a case of a young woman with severe acute malnourishment who had a history of painful swelling in her left renal angle after contracting a urinary tract infection. A radiological examination revealed a massive staghorn calculus in the left kidney with significant hydronephrosis, resulting in a retroperitoneal abscess. The patient had surgical treatment along with free drainage of 1000 millilitres of pus. The systemic antibiotic was given as urosepsis treatment. Percutaneous nephrolithotomy (PCNL) and placement of a double-J catheter were performed as definitive treatment for staghorn calculi three months later. Interestingly, it was the second episode of urolithiasis in this patient in 10 years. Malnourishment and recurrent Urinary Tract Infection (UTI) may be predisposing factors to staghorn calculi and perirenal abscess. Conclusion: Considering its significant problem, early evaluation, treatment, and prevention of recurrence were essential to decrease morbidity and mortality in pediatric urolithiasis.
Co-Authors Astrid Kristina Kardani desy wulandari Krisni Subandiyah Susanto Nugroho Wisnu Barlianto