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All Journal SAINSMAT Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Rian Andrianto
Universitas Hasanuddin
Education Medicine & Pharmacology

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Simulasi Sifat Fisis Model Molekuler Dinamik Gas Argon dengan Potensial Lennard-Jones Bahari Nurdin, Wira; Andrianto, Rian
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol 1, No 2 (2012): September
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/sainsmat127392012

Abstract

DOWNLOAD PDFTelah  dilakukan  pembuatan  dan  pengujian  suatu  simulasi  tentang  sifat  fisis  gasargon  dengan  menggunakan  dinamika  molekuler  menggunakan  potensial Lennard-Jonesdalam sistem terisolasi (ensemble mikrokanonik). Jumlah molekul, energi total sistem danluas  kotak  simulasi  telah  divariasikan.  Untuk  menghitung  perubahan  posisi  digunakanalgoritma Verlet. Sifat fisis yang ditentukan dalam simulasi adalah temperatur dan energitotal  sistem  untuk  menentukan  adanya  fase  transisi.  Dari  hasil  simulasi,  terdapatkesesuaian antara simulasi dengan gas argon dan tidak diperoleh adanya fase transisi.Kata kunci: Simulasi dinamika molekul, argon, potensial Lennard-Jones, ensemblemikrokanonik, algoritma Verlet
Enhancing Solubility and Dissolution of Caffeine Through Solid Dispersions with Polyvinylpyrrolidone K-30: A Comparative Study of Drug-to-Polymer Ratios Indra, Indra; Andrianto, Rian; Aryani, Ratih
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.12695

Abstract

Despite its inherently high aqueous solubility, caffeine demonstrates inconsistent oral bioavailability due to formulation and processing-related limitations. This study aimed to improve the solubility and dissolution rate of caffeine by formulating solid dispersions using polyvinylpyrrolidone K-30 (PVP K-30) via the solvent evaporation method. Solid dispersions were prepared at drug-to-polymer ratios of 1:1, 1:2, and 2:1, and characterized using hot-stage microscopy (HSM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) analysis. Solubility and dissolution testing were conducted in phosphate buffer (pH 6.8). The results showed that the 1:2 ratio formulation yielded the most significant improvement, with solubility reaching 22.3 mg/mL and a dissolution rate of 97.6% within 30 minutes, representing a substantial enhancement compared to pure caffeine. FTIR and DSC indicated the presence of hydrogen bonding and the absence of caffeine melting peak, while PXRD confirmed amorphization. These findings suggest that solid dispersion with PVP K-30 is a viable strategy for overcoming the bioavailability challenges of caffeine and similar compounds, warranting further investigation into in vivo performance and long-term stability.
Co-Authors Indra Indra Ratih Aryani, Ratih Wira Bahari Nurdin