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All Journal Journal of General Procedural Dermatology and Venereology Indonesia
Handayani, Theressia
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Medicine & Pharmacology

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Facial skin rejuvenation with poly-l-lactic acid (PLLA): Four case studies Setiawan, Stanley; Handayani, Theressia; Luziani, Stefani
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Background: Facial aging is characterized by the decline and loss of skin structure. Poly-l-lactic acid (PLLA) is a biopolymer and biodegradable injection material that functions as a collagen stimulator. This active ingredient works by stimulating the formation of skin collagen after interacting with the PLLA crystal component. The expected final result is an increase in the skin volume with the thickening and increased density of the skin layers due to collagen remodeling. At present, data on the application of PLLA for facial photorejuvenation remains limited. Case Illustration: Four patients aged 22-49 years old, with different severity of aging, underwent PLLA injection procedures. The active component was administered through injection with a dilution ratio of 1:1 to 1:2 for the cheeks and temporal area and without dilution for the forehead, smile lines, and chin area. After the injection, a gentle massage was performed, and the patient was instructed to self-massage every day. Each patient was evaluated on the twentieth day and underwent additional injection sessions up to two times. Discussion: All patients showed improvement as assessed using photography and the Global Aesthetic Improvement Scale (GAIS) 20 days after the procedure. All patients were satisfied with the final result. There was no significant pain during the procedure. Conclusion: PLLA injection is a safe and effective procedure that stimulates the formation of new collagen adequately. Patient satisfaction with the treatment was excellent, and no complications were observed in all patients.
Topical Application of Exosomes in a Patient with Acne Conglobata: A Case Report Handayani, Theressia; Luziani, Stefani
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
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Background: Acne conglobata (AC) is a rare and severe acne characterized by interconnected nodules, cysts, and abscesses. Mesenchymal stem cell-derived exosomes (MSC-exosomes) have immunosuppressive properties that alleviate inflammation and immunological reactions. We present a case of AC in a patient who received topical administration of exosomes. Case Illustration: A 20-year-old male was diagnosed with AC, presenting as inflammatory papules and cysts covered with yellowish crusts that had been present for five months. Exosomes (ASCE+®, Seoul, South Korea) were topically administered at a dose of 5 mL, applied evenly to the face. The patient underwent three treatment sessions, with a one-week interval between sessions. Photographic images were captured before treatment, immediately after the final session, followed by one week and then three weeks after the final treatment session. The patient expressed complete satisfaction with the implemented treatment and disclosed no adverse effects. Discussion: The present case report illustrates the therapeutic advantages associated with the use of exosomes in a patient with AC. The therapeutic targeting of inflammatory regulators is crucial in treating AC. Studies have shown that MSCs possess inherent immunosuppressive properties that can help alleviate inflammation and immunological reactions. MSC-exosomes offer additional benefits, including angiogenic capacity and collagen synthesis. The study's limitations include the short follow-up duration and the lack of a control group. Conclusion: Exosomes have the potential to serve as cosmeceutical in the treatment of AC, due to their anti-inflammatory, regenerative, and antimicrobial properties.
Co-Authors Luziani, Stefani Setiawan, Stanley