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All Journal Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal
Luziani, Stefani
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Facial skin rejuvenation with poly-l-lactic acid (PLLA): Four case studies Setiawan, Stanley; Handayani, Theressia; Luziani, Stefani
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Facial aging is characterized by the decline and loss of skin structure. Poly-l-lactic acid (PLLA) is a biopolymer and biodegradable injection material that functions as a collagen stimulator. This active ingredient works by stimulating the formation of skin collagen after interacting with the PLLA crystal component. The expected final result is an increase in the skin volume with the thickening and increased density of the skin layers due to collagen remodeling. At present, data on the application of PLLA for facial photorejuvenation remains limited. Case Illustration: Four patients aged 22-49 years old, with different severity of aging, underwent PLLA injection procedures. The active component was administered through injection with a dilution ratio of 1:1 to 1:2 for the cheeks and temporal area and without dilution for the forehead, smile lines, and chin area. After the injection, a gentle massage was performed, and the patient was instructed to self-massage every day. Each patient was evaluated on the twentieth day and underwent additional injection sessions up to two times. Discussion: All patients showed improvement as assessed using photography and the Global Aesthetic Improvement Scale (GAIS) 20 days after the procedure. All patients were satisfied with the final result. There was no significant pain during the procedure. Conclusion: PLLA injection is a safe and effective procedure that stimulates the formation of new collagen adequately. Patient satisfaction with the treatment was excellent, and no complications were observed in all patients.
The combination of Q-switched neodymium:yttrium–aluminum–garnet (Nd:YAG) laser with photoacoustic pulse technology in combination with polynucleotides (PN) salmon DNA for skin rejuvenation: A case series Setiawan , Stanley; Handayani , Theressia; Luziani, Stefani
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 7, Issue 1 (January 2024)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v7i1.95

Abstract

Background: Skin aging leads to dyspigmentation, wrinkles, and lentigines. Photorejuvenation, especially Q-switched Nd:YAG laser therapy, is commonly used to address these concerns. We present a case series evaluating the effectiveness of combining Q-switched Nd:YAG laser with Polynucleotides (PN) Salmon DNA for facial photorejuvenation. Case series: Five healthy adults underwent four sessions of full-face laser toning with a QS 1064 nm Nd:YAG laser followed by Polynucleotide (PN) Salmon DNA 2% injections every two weeks. We recorded subjective assessments and pain levels during treatment and captured photographic images for analysis. The treatment significantly improved skin brightness and pigmentation, with some subjects achieving mild or no pigmentation. Skin elasticity improvements varied among subjects. Some experienced significant enhancement, while others showed minor changes or none at all. Skin redness responses varied. Objective measurements revealed pore size, skin elasticity, moisture, skin tone, wrinkles, and skin age improvements. Conclusion: Combining Q-switched Nd:YAG laser with PN Salmon DNA shows promise for enhancing skin health and appearance.
Drug reaction with eosinophilia and systemic symptoms (DRESS) with acute kidney injury and transaminitis: A rare case Luziani, Stefani; Roslina, Nina; Zakaria, Rio; Sumarmi
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 8, Issue 1 (2025)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v8i1.108

Abstract

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, serious, and potentially life-threatening drug hypersensitivity reaction. The diagnosis of DRESS can be challenging to make because of the highly variable clinical presentation, progressive onset of manifestations, and the extended period from drug exposure to onset. Many DRESS cases remain undiagnosed or misdiagnosed. This study aims to report a rare case of an adult patient with DRESS to expand our knowledge and avoid delayed identification and treatment. Case: A 31-year-old male presented to the emergency department with a chief complaint of itchy, red desquamation rashes all over his body, with fever and swelling on his face. The dermatological status obtained was a generalized distribution; on nearly the entire body surface area, there were multiple lesions, confluent, with unclear boundaries, irregular in shape, plaque-sized, not raised, dry, in the form of erythematous macules with scales and light yellow crusts. Hematological laboratory analysis revealed hypereosinophilia. The renal function indicated a decreased eGFR of over 75%, and the hepatic function test revealed an elevated in liver function. The patient was diagnosed with DRESS, acute kidney injury, and transaminitis. There was an improvement in the patient's condition following the withdrawal of the previous medications and the administration of intravenous dexamethasone, oral antihistamine, and symptomatic treatment. Conclusion: Early identification and withdrawal of all suspected medications are essential for the management of DRESS, as a delayed diagnosis can be life-threatening. The administration of systemic steroids is efficacious for the treatment of DRESS.
Topical Application of Exosomes in a Patient with Acne Conglobata: A Case Report Handayani, Theressia; Luziani, Stefani
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Background: Acne conglobata (AC) is a rare and severe acne characterized by interconnected nodules, cysts, and abscesses. Mesenchymal stem cell-derived exosomes (MSC-exosomes) have immunosuppressive properties that alleviate inflammation and immunological reactions. We present a case of AC in a patient who received topical administration of exosomes. Case Illustration: A 20-year-old male was diagnosed with AC, presenting as inflammatory papules and cysts covered with yellowish crusts that had been present for five months. Exosomes (ASCE+®, Seoul, South Korea) were topically administered at a dose of 5 mL, applied evenly to the face. The patient underwent three treatment sessions, with a one-week interval between sessions. Photographic images were captured before treatment, immediately after the final session, followed by one week and then three weeks after the final treatment session. The patient expressed complete satisfaction with the implemented treatment and disclosed no adverse effects. Discussion: The present case report illustrates the therapeutic advantages associated with the use of exosomes in a patient with AC. The therapeutic targeting of inflammatory regulators is crucial in treating AC. Studies have shown that MSCs possess inherent immunosuppressive properties that can help alleviate inflammation and immunological reactions. MSC-exosomes offer additional benefits, including angiogenic capacity and collagen synthesis. The study's limitations include the short follow-up duration and the lack of a control group. Conclusion: Exosomes have the potential to serve as cosmeceutical in the treatment of AC, due to their anti-inflammatory, regenerative, and antimicrobial properties.
Co-Authors Handayani , Theressia Handayani, Theressia Rio Zakaria Roslina, Nina Setiawan , Stanley Setiawan, Stanley Sumarmi