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All Journal JURNAL GIZI INDONESIA Jurnal Abdi Insani
Putri, Mahendri Deayu
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Red dragon fruit juice in reducing ros levels and insulin resistance In rats with type 2 diabetes mellitus model Putri, Mahendri Deayu; Wiboworini, Budiyanti; Dirgahayu, Paramasari
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 10, No 1 (2021): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.10.1.6-14

Abstract

Background: The peel of red dragon fruit (Hylocereus polyrhizus) had been proven to have a total polyphenol content and total flavonoids 2 to 3 times more than its flesh. These components could reduce oxidative stress and maintain the function of pancreatic beta cells, which could affect blood sugar levels.Objectives: This study aimed to test the red dragon fruit juice using peel and flesh to reduce oxidative stress and insulin resistance in T2DM model rats.Materials and Methods: This study was a true experimental study with a randomized controlled trial, with a Matching Pretest Post-test Control Group Design. We used 21 white male rats (Rattus norvegicus) Wistar strain which was divided into three groups: (P1) negative control group (induced Streptozotocin + Nicotinamide induction), (P2) positive control group (given Streptozotocin + Nicotinamide and given Metformin HCl induction 0,9 mg/kg BW, and (P3) Red Dragon fruit group (induced Streptozotocin + Nicotinamide and given Red Dragon Fruit juice 3.6 ml / 200 g BW / day given for 14 days. The data were analyzed using a one-way ANOVA test, paired t-test, and Post Hoc.Results: After 14 days of intervention, the average HOMA-IR levels were as follows: negative control group (Mean=8.32; SD=0.26), positive group (Mean 4.89; SD=0.29), and the Red Dragon Fruit intervention group (Mean=4.65; SD=0.30). The average MDA levels were as follows: control group (Mean = 9.08; SD = 0.68), positive group (Mean=3.34;SD=0.22), and the red dragon fruit intervention group (Mean = 3.05; SD = 0.47). Both the Metformin group and the Red Dragon Fruit group had low HOMA-IR and MDA levels compared to the negative control group.Conclusions: When administered alone, red dragon fruit and metformin effectively reduced HOMA-IR and MDA levels in rats with type 2 DM. Red dragon fruit can be used as an alternative to metformin because of its effectiveness in reducing plasma HOMA-IR and MDA.
IMPLEMENTASI PERAK SEHAT: INTEGRASI EDUKASI GIZI KLINIK, LEAFLET KODE QR, DAN DEMONSTRASI MASAK PANGAN LOKAL UNTUK PENCEGAHAN STUNTING Widyaningsih, Yasinta Indah; Ambas, Jasmin; Amin, Andi Nurzakiah; Putri, Mahendri Deayu; Harfah, Nurfalia
Jurnal Abdi Insani Vol 13 No 1 (2026): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v13i1.3096

Abstract

Stunting is a chronic nutritional problem that affects children's physical growth and cognitive development, particularly during the first 1,000 days of life. The contributing factors include unbalanced nutrient intake, inadequate parenting practices, recurrent infections, and limited access to healthcare services. Preventing stunting requires a comprehensive strategy that enhances knowledge, fosters positive attitudes, and strengthens balanced nutrition practices within the community. This community service activity, titled “Implementation of PERAK SEHAT: Integration of Clinical Nutrition Education, QR Code Leaflets, and Local Food Cooking Demonstrations for Stunting Prevention,” aimed to improve participants’ knowledge, attitudes, and behavioral intentions related to balanced nutrition. The methods employed included interactive lectures, group discussions, and cooking demonstrations using local food ingredients, involving pregnant women, mothers of toddlers, and adolescent girls in Bonto Perak Village, Pangkajene and Islands Regency. Evaluation was conducted through pre-test and post-test assessments to measure changes in knowledge, attitudes, and behavioral intentions. The results showed an increase in participants’ knowledge, positive attitude shifts, and stronger commitment to applying balanced nutrition principles. The digital leaflet served as a reinforcing medium that enabled participants to revisit the information at home. In conclusion, this activity proved to be an effective public health promotion strategy by integrating education and practical application to encourage positive behavioral changes related to balanced nutrition as an effort to prevent stunting.
Co-Authors Amin, Andi Nurzakiah Budiyanti Wiboworini Harfah, Nurfalia Jasmin Ambas Paramasari Dirgahayu Widyaningsih, Yasinta Indah