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Nainggolan, Hotlina
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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

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Effect of Suruhan Leaves (Peperomia pellucida L. Kunth) Extract on Triglyceride Blood Level in Diabetic Rats Hafita Dinda Maryana; Nainggolan, Hotlina; Nadia Rusyda Hanifa
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.53-60

Abstract

Background: Diabetes Mellitus causes complications, such as hypertriglyceridemia. Indonesia has biological wealth diversity that can be exploited in alternative medicine. One of which is Suruhan plants. Flavonoid contents in the plant extract can normalize blood triglyceride levels. Objective: This study aims to determine the effect of the Suruhan extract (Peperomia pellucida L. Kunth) on blood triglyceride levels in alloxan-induced diabetic white rats. Methods:  The induction process used alloxan at a dose of 150mg/kgbw intraperitoneally to 12 rats. The rats were divided into 5 research groups, namely normal rats, diabetic rats, and diabetic rats were given various doses of extract. The treatment was carried out for 14 days. Blood samples for triglyceride examination were taken at the end of the study. Results: blood triglyceride levels were obtained in the normal group (127.67 mg/dl); and diabetic control group (395.67mg/dl); the dose group was 20mg/kg BW (216mg/dl); the dose group was 40 mg/kg BW (159.33 mg/dl) and the dose group was 80 mg/kg BW (143.33 mg/dl) in the statistical test with one way ANOVA (p <0.05) obtained significance with a value of p = 0.000. Conclusions: There is an influence of plant extracts (Peperomia pellucida [L.] Kunth) administration on the blood reduction of triglyceride levels in diabetic white rats induced by alloxan.
Effect of Combined Angiotensin-Converting Enzyme Inhibitor and Calcium Channel Blocker Therapy on Blood Glucose Level in Sprague-Dawley Rats Mulianingtyas, Grace Valentina; Nainggolan, Hotlina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.399-406

Abstract

Background: Hypertension is related to high blood pressure, with values above 140/80 mm Hg, and is a major contributor to morbidity in Indonesia. Pharmacotherapy is recommended for patients with high-grade hypertension and can be administered as monotherapy or combination therapy. Angiotensin-converting enzyme inhibitors (ACEIs), such as captopril, and calcium channel blockers (CCBs), such as amlodipine, were among the most prescribed combination therapies. Case reports suggest that ACEIs are associated with hypoglycemia, whereas CCBs are associated with hyperglycemia. However, no studies related to blood glucose show results in combining use. Objective: This study aimed to test the effect of ACEI and CCB combination on blood glucose levels in Sprague-Dawley rats. Methods: Twenty-five Sprague-Dawley rats (6-8 weeks old) were divided into 5 groups of 5 animals each consisting of normal, negative control, amlodipine, captopril, and combination group. The test lasted for 21 days, and blood glucose levels were measured every 7 days. The significance level was set at p-value<0.05 to determine whether there was an effect on blood glucose. Results: There were significant differences in blood glucose levels before and after treatment in the amlodipine and combination groups with significance levels, respectively, p=0.003; 0.046 (p<0.05). Conclusion: Among all test groups, amlodipine showed a significant results in affecting blood glucose and resulting in hyperglycemic events. While the combination showed a significant difference, it did not lead to hyperglycemia.
Co-Authors Fadhila, Rizky Hafita Dinda Maryana Harits Atika Ariyanta Herliani, Upi Masyithah, Lathvi Mulianingtyas, Grace Valentina Nadia Rusyda Hanifa Novita Mandagi, Novita Oktavilantika, Dina Melia Rachmi Ridho Suzana, Dona