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All Journal Indonesian Journal of Urology Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh International Journal of Public Health Excellence (IJPHE)
Dahril
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Journal of Medical Science

 1 
Pengaruh daun kelor dan dislipidemia terhadap kuantitas sperma Dahril; Muhammad Puteh Mauny; Munandar, Rudi Haris
Journal of Medical Science Vol 2 No 2 (2021): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (397.507 KB) | DOI: 10.55572/jms.v2i2.44

Abstract

Infertility is a global health problem affecting 1 of 10 couples in the world and its related to dyslipidemia. Dyslipidemia, as metabolic syndrome, had become global epidemic. It is estimated 12-37% Asian population and 12-26% of European population had dyslipidemia. Dyslipidemia decreased sperm count by increasing free radical oxygen species (ROS) caused of lypotoxicity and lipid peroxidation. Antioxidant is treatment choice for this problem. Drum stick (Moringa oleifera L) is medical herb that contain antioxidant compound such as alkaloid, flavonoid, tannin, vitamin C, E, and steroid. So, Moringa oleifera L leaf could protect sperm cells from free radicals of dyslipidemia and become alternative treatment for infertility. It was a post-test only control group design. Sample consist of 30 rats devided into 6 groups. It began with atherogenic diet to induce dyslipidemia. Then, Ethanol extract of Moringa oleifera L leaf was given. Sperm count was calculated microscopically with Neubauer chamber. Data analysis was using one way analysis of variance (ANNOVA) test, then continued with post hoc Duncan test. There were significant differences of total cholesterol, triglyceride, high density protein, low density protein, and sperm count between groups based on one way ANNOVA test (p < 0,05). On post hoc Duncan test, Dyslipidemia induction decreased sperm count compared to other groups. Ethanol extract of 200 mg/body weight and 400 mg/body weight leaf had no difference effect compared to atorvastatin. Ethanol extract of 800 mg/body weight leaf increased sperm count significantly compared to other groups.
Pengaruh Diuretik Terhadap Stone-Free Rate Batu Ureter dengan Pneumatic Lithotripsy Jufriady Ismy; Muhammad Ridha; Dahril; Rayyan Al Faruqi; Muyasir
Journal of Medical Science Vol 3 No 2 (2022): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v3i2.82

Abstract

Pneumatic Lithotripsy (PL) is considered effective in fragmenting hard stones, and this procedure can also be performed transurethrally and percutaneously on large stones. This study aimed to see the percentage of Stone Free Rate (SFR) by administering force diuretics to ureteral stones that were crushed using PL. Previous studies have found that intravenous loop diuretic administration is effective, safe, and efficient in obtaining a much higher percentage of SFR and can reduce the average number of sessions per stone during extracorporeal shock wave lithotripsy (ESWL). We identified study subjects from early July-September 2022 and obtained as many as 38 study subjects (SP) with stones in the distal ureter <20mm. Subjects were randomly selected and divided into two groups: the group given diuretics (K2) and not given (K1). With a 90% confidence degree and 15% sampling error, based on Lameshow's formula, 30 SP can be observed; eight other subjects were excluded because they experienced a decrease in systolic pressure >25% (5 SP) and the remaining stones came out without splitting (3SP). The results obtained were SFR levels that were statistically significant (p<0.05) and clinically using the Mann-Whitney statistical test. Administration of diuretics to patients with distal ureteral stones undergoing URS with Pneumatic Lithotripsy is safe and effective as an anti-retropulsion method. It is the strategy of choice in centers that do not provide laser lithotripsy or flexible ureteroscope.
Pengaruh Daun Kelor Untuk Pencegahan Infertilitas Akibat Trauma Fisik Testis Dahril; Jufriady Ismi; Ahmad Afandi
Journal of Medical Science Vol 4 No 1 (2023): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v4i1.91

Abstract

Trauma testis menjadi penyebab tersering ketiga dari nyeri skrotum akut yang dapat mengakibatkan berbagai tingkat kerusakan testis, sehingga dapat menyebabkan infertilitas. Trauma testis merupakan faktor risiko infertilitas terkait dengan adanya peningkatan radikal bebas, inflamasi yang berdampak pada penurunan kualitas sperma, dan kerusakan Blood Testis Barrier (BTB). Lima dari 9 testis yang mengalami trauma menjadi atrofi. Salah satu tatalaksana yang dapat dilakukan untuk mengatasi hal tersebut adalah dengan pemberian antioksidan. Tanaman kelor (Moringa oleifera)  mengandung beberapa senyawa antioksidan seperti senyawa golongan alkaloid, flavonoid, tanin, vitamin C, vitamin E, dan steroid. Diharapkan daun kelor juga dapat melindungi sel sperma dari oksidan bebas akibat trauma testis dan secara tidak langsung menjadi salah satu pilihan terapi infertilitas. Penelitian ini merupakan penelitian eksperimental menggunakan rancangan the post-test only control group design. Setelah dilakukan adaptasi selama 2 minggu, dibuat perlakuan torsio testis pada 30 ekor tikus rattus novergicus yang dibagi  ke dalam 5 kelompok perlakuan, kemudian dilakukan analisis sperma. Analisis data perbedaan antar kelompok menggunakan uji analisis of variance (ANNOVA) satu arah. Hasil penelitian menemukan konsentrasi spermatozoa (39.80 ± 17.88 x106 spermatozoa/ml) pada kelompok dosis 800 mg lebih tinggi dibandingkan kelompok dosis 400 mg (27.94 ± 14.76 x106 spermatozoa/ml), dan kelompok dosis 200 mg (25.32 ± 19.33 x106 spermatozoa/mL). Hal ini menunjukkan bahwa pemberian ekstrak tanaman kelor dosis 800 mg lebih berpengaruh atau mampu mempertahankan konsentrasi spermatozoa tikus wistar pada torsio testis dibanding  dosis 400 mg dan 200 mg. Penelitian ini menyimpulkan daun kelor memiliki potensi dalam tatalaksana infertilitas terkait trauma testis.
Co-Authors Ahmad Afandi Bonar, Ananta Furqan Hidayatullah Ikhwan, Haznur Ismy, Jufriady Jufriady Ismi Khalilullah, Said Alfin Mauny, Muhammad Puteh Muhammad Puteh Mauny Muhammad Ridha Muhammad Ridha Munandar, Rudi Haris Muyasir Rayyan Al Faruqi Reza Maulana Triyaka, Rendy