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All Journal Padjadjaran Journal of Dentistry Odonto dental journal
Abdurrohman, Muhamat Muhtar S
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Effect coffee administration on alkaline phosphatase levels during relapse following orthodontic retention in rats: an experimental study Tyas, Septa Yumnaning; Abdurrohman, Muhamat Muhtar S; Mahardika, Christina; Yusuf, Moh
Padjadjaran Journal of Dentistry Vol 36, No 3 (2024): November 2024
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol36no3.57868

Abstract

Introduction: Maintaining teeth in their corrected positions following orthodontic treatment can be extremely challenging. Coffee is one substance whose effects on relapse have been extensively studied. The aim of study is to analyze the effect of coffee administration on relapse after orthodontic retention by evaluating alkaline phosphatase levels. Methods: This experimental laboratory study enrolled SpraqueDawley rats, with brackets applied using Edgewise slot 0.022” system and a nickel-titanium open coil spring fixed between the lower central incisors for 14 days. Based on Federer’s formula, 36 SpraqueDawley rats were randomly divided by simple random sampling into four groups: Group 1 (no retention), Group 2(retention for 3 days), Group 3(retention for 7 days), and Group 4(retention for 2 weeks). The Spraque-Dawley rats in the four experimental groups were given aquadest, 50 mg, and 100 mg/kg coffee intake ad libitum. Orthodontic relapse was assessed by measuring changes in alkaline phosphatase levels between the lower central incisors (the relapse side). Changes in the distance between the central incisors during relapse were observed visually. Alkaline phosphatase levels, which serve as a predictor of recurrence, were determined using an enzyme-linked immunosorbent assay (ELISA). Data analysis was conducted with the Two-way analysis of variance (ANOVA) and a post hoc Tukey test. Results: Overall, we found that a longer retention period was associated with a slower rate of relapse and a shorter overall amount of relapse. In addition, inhibiting osteoclast formation using coffee also reduced orthodontic relapse. Alkaline phosphatase (ALP) and/or its biomarkers could serve as potential therapeutic targets in the prevention and treatment of orthodontic relapse, with changes observed at a value of 0.001. This demonstrates that coffee administration affects alkaline phosphatase levels during relapse after orthodontic retention. Conclusion: Coffee administration increased alkaline phosphatase levels during relapse after orthodontic retention in rats.
THE EFFECT OF GIVING ALOE VERA GEL ON RATS WITH BACTERIA-INDUCED PERIODONTITIS Abdurrohman, Muhamat Muhtar S; Putranto, Rama; Suhartono, Budi; Fa'adiyah, Dhiya almanda
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (342.973 KB) | DOI: 10.30659/odj.8.2.140-145

Abstract

ABSTRACTBackground: Aloe vera (AV) contains a variety of characteristic antibiotic and anti-inflammatory components that have potential advantages for periodontal disease therapy. Diagnostic and prognostic markers of periodontal disease through the activity of alkaline phosphatase (ALP) in gingival crevicular fluid. This study was conducted to evaluate the effect of giving AV gel on alkaline phosphatase levels in rats with bacteria-induced periodontitisMethod: Thirty-six male Sprague dawley were healthy and active, weighing 170-200 grams, aged 2 months were distinguished into two groups: the control group of periodontitis given therapy Gel Metronidazole plus 25% and AV gel 99.03% as a treatment group. Aloe vera gel is administered topically in gingival sulcus at a dose of 300 mg/kg of rat weight. Samples were taken from gingival sulcus liquid on days 1, 2 and 3 using periopaper paper. Alkaline phosphatase levels are measured using a UV/Vis Spectrophotometer with a wavelength of 405 nm. Variant analysis is used to compare ALP levels in different groupsResult: There was significant difference in alkaline phosphatase levels between the control group and the treatment group (p>0.05). In Sprague dawley rats with periodontitis, there was a significant decrease in ALP levels on days 1, 2 and 3 given Metronidazole gel plus 25% therapy and AV gel 99.03%. But the treatment group showed lower ALP levels than the control groupConclusion: This study revealed that the use of AV gel locally has an effect and can be as an adjunct therapy for periodontitis
Co-Authors Ardiansyah, M. Shulchan Fa'adiyah, Dhiya almanda Fadilasari, Annisa Mahardika, Christina Moh Yusuf, Moh Rama Putranto Suhartono, Budi Tita Ratya Utari Tyas, Septa Yumnaning Wardana, Puspitarini Nindya