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All Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
Muhammad Aron Pase
Division Of Endocrinology Metabolic And Diabetes, Department Of Internal Medicine, Faculty Of Medicine, Universitas Sumatera Utara
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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THE RELATIONSHIP BETWEEN DIABETES MELLITUS AND THE SEVERITY OF KNEE OSTEOARTHRITIS BASED ON X-RAY IMAGING AT HAJI ADAM MALIK GENERAL HOSPITAL MEDAN Muhammad Akbar Batubara; Evo Elidar Harahap; Muhammad Aron Pase
MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Vol. 5 No. 2 (2024): June
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59733/medalion.v5i2.115

Abstract

Background: Osteoarthritis (OA) is a degenerative joint disease resulting from the destruction of joint cartilage to the formation of subchondral bone and osteophytes that cause pain in the joints. According to WHO, the prevalence of OA in Southeast Asia in 2004 reached 27.4 million people. One of the metabolic disorders that is thought to be a risk factor for OA progressivity is Diabetes Mellitus (DM). Indonesia has the fourth largest number of DM patients with a prevalence of 8.6% of the total population. Current evaluation of OA is based on clinical and radiographic examinations such as X-ray, MRI, CT etc. The Kellgren-Lawrence (KL) system is a validated method to classify the severity of OA into 5 levels. Objective: To determine the relationship between DM and the severity of genu OA based on X-ray photographs at Haji Adam Malik Hospital Medan. Methods: This study used a cross sectional design. The data obtained will then be processed and analyzed with the Chi-Square test, Fisher Exact test, or Kruskal-Wallis test using a data processing program. Results: It was found that DM patients with right genu OA location amounted to 29 people (39.7%), left amounted to 13 people (17.8%), and both amounted to 31 people (42.5%). DM patients with grade 1 severity amounted to 6 people (8.2%), grade 2 amounted to 18 people (24.7%), grade 3 amounted to 25 people (34.2%), and grade 4 amounted to 24 people (32.9%). The results of the Chi-Square test found that there was a significant relationship between DM and the severity of genu OA (p<0.001). Based on Kruskal-Wallis test, there was no significant relationship between DM comorbidity and genu OA severity (p=0.636) and there was no significant relationship between OA severity and HbA1c (p=0.408). Conclusion: There is a significant relationship between DM and the severity of genu OA based on X-ray photos at Haji Adam Malik Hospital Medan.
The Differences of TNF-α Levels and BMI in Diabetic Patients with Pulmonary Tuberculosis After Intensive Phase of Tuberculosis Treatment Lydia, Wika; Nasution, Melati Silvanni; lubis, Dian Anindita; Muhammad Aron Pase
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 2 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (760.498 KB) | DOI: 10.32734/jetromi.v2i2.3873

Abstract

Abstract. Introduction. Diabetes Melitus (DM) can cause complications, such as pulmonary tuberculosis (TB). Metabolic disorders are thought to be related to Tumor Necrosis Factor-α (TNF-α) metabolism, adipocytokines secreted by macrophages, which inhibit insulin transduction, has anti-mycobacterial activity, however, also negatively affect pathological TB process. This study aims to determine differences in TNF-α levels and Body Mass Index (BMI) in DM with pulmonary TB after intensive phase of antituberculosis treatment. Method. This prospective comparative analytical study with one-group pretest-posttest design, conducted during August 2019-September 2019 in outpatient of Type 2 DM with pulmonary TB at USU Hospital, Madani Medan Hospital, Teladan Health Center and Laboratory of Haji Adam Malik Medan after approval from the Health Research Ethics Commission. Data were analyzed after normality test, then mean difference and correlation test by using the SPPS program where p <0.05 was considered significant. Results. This study showed an increase BMI, and decrease of fasting blood glucose, 2-hour post-prandial blood glucose, HbA1C and TNFα levels before and after intensive phase of antituberculosis treatment (p = 0,000; p = 0,000; p = 0,000; p = 0,000). Conclusion. There was a significant increase of BMI and decrease of TNFα level after intensive phase of antituberculosis treatment.
Effects of Ramadan Fasting on Lipid Profiles and Interleukin-6 in Obese Patients: Effects of Ramadan Fasting on Lipid Profiles and Interleukin-6 in Obese Patients Lubis, Frihastina; Muhammad Aron Pase
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 2 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (715.11 KB) | DOI: 10.32734/jetromi.v2i2.3880

Abstract

Abstract. Obesity can cause a state of chronic low-grade inflammation due to hypertrophy and hyperplasia of adipose tissue which is not followed by the formation of balanced vascularization. Interleukin-6 is one of the mediators of inflammation that results from obesity. Changes in lifestyle during fasting for the entire month of Ramadan are thought to have an effect on the lipid profile and inflammatory mediators. Method. This research is a prospective cohort observational study conducted in March 2019-May 2019 endocrine polyclinic outpatient clinic Haji Adam Malik Hospital Medan in 30 subjects. Anthropometric measurements and examination of lipid profiles and IL-6 levels, one week before Ramadan fasting and the fourth week of Ramadan. Results. This study showed that there were significant differences in total cholesterol and HDL levels in the study subjects before and after Ramadan fasting (p <0.001; p = 0.049). Also found significant differences in median IL-6 study subjects before and after Ramadan fasting (p <0.001). Conclusion. There was a decrease in levels of IL-6, a decrease in total cholesterol and a statistically significant increase in HDL in obese patients undergoing Ramadan fasting.
Correlation between HbA1C and D-dimer in Type 2 Diabetic with COVID-19 Patients Pangaribuan, Jessica Patricia; M. Aron Pase
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 3 No. 4 (2021): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (783.826 KB) | DOI: 10.32734/jetromi.v3i4.7529

Abstract

Background: Coronavirus disease-19 (COVID-19) is the disease caused by 2019-nCoV/SARS-CoV-2, a novel β corona- virus of group 2B . COVID-19 has been reported to be associated with severe condition with type 2 diabetes mellitus (T2DM). D-dimer is a by product of fibrin degradation. It is widely recognized as a biomarker for thromboembolism and as a prognostic marker for critical patients. Methods: This study uses secondary data, which is obtained by looking at the contents of patient medical records at H. Adam Malik Medan Hospital between 2020-2021. The population of this study was all inpatients confirmed COVID-19 through an RT-PCR SARS-CoV-2 swab examination. The study sample was obtained by the total sampling method, where all populations that meet the criteria of inclusion and exclusion are used as research samples. Patients were triaged as per severity on basis of national guidelines: asymptomatic, Mild (respiratory rate < 24/min, SpO2 >94% at room air), moderate (respiratory rate: 24-30/min, SpO2 90-94% at room air) and severe (respiratory rate >30/min SpO2 < 90%), ARDS and septic shock [6]. HbA1c implementation using HPLC methods and D-dimer is measured by ELISA method. Result: There were 163 patients consisting of 92 men and 71 women, the average age was 56.9±10.3 years, and HbA1c, FPG and PPG remained uncontrolled. There were no differences in age parameters of blood sugar profiles and D-dimers between men and women. D-dimers are significantly negatively correlated with PPG. Conclusion: Age, blood sugar profile and D-dimer did not differ significantly between men and women, and D-dimer had a correlation significantly with PPG on T2DM with COVID-19 patients. Keywords : D-dimer, T2DM, COVID-19
Correlation Between the Ratio TG/HDL-C and Lipid Profile in Nonalcoholic Fatty Liver Disease Patients Siregar, Hafiz Syaifullah; M.Aron Pase
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 4 No. 1 (2022): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v4i1.8595

Abstract

Background: Insulin resistance is identified as an impaired biological response to insulin stimulation of target tissues primarily in the liver, muscle, and adipose tissue. The ratio TG/HDL-C has been proposed as a simple marker of insulin resistance. The study aimed to determine the correlation between the ratio TG/HDL-C and lipid profile in nonalcoholic fatty liver disease (NAFLD) patients Method: The design of the study was a cross-sectional study with the dependent variable Fibrosis Score of NAFLD sufferers who came to H. Adam Malik Medan General Hospital network hospital from July-September 2021. Diagnosis of NAFLD from anamnesis, physical examination, laboratory, and abdominal ultrasound. Lipid profile examination is carried out using a spectrophotometer tool colorimetric enzymatic method, observed include TC, HDL-C, LDL-C, and TG. Results: There are 80 NAFLD patients, aged 54.8±8.7 years, with uncontrol T2DM, and normal weight. There was a correlation significantly between the ratio TG/HDL-C with TC-C, TG, HDL-C, LDL-C (p<0.001), and no correlation between ratio TG/HDL-C with age, BMI, FPG, PPG, and HbA1c (p>0.05) Conclusion: There is a correlation between ratio TG/HDL-C (as a marker of insulin resistance) and lipid profile in NAFLD patients
Tirzepatide: Dual GIP/GLP-1 Receptor Agonists, from Molecular to Clinical Practice for Treating Type-2 Diabetes and Obesity Muhammad Aron Pase
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 2 (2024): InaJEMD Vol. 1, No. 2
Publisher : PP PERKENI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tirzepatide is a promising drug with dual-acting glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor activation that has revolutionized the treatment of type 2 diabetes mellitus (T2DM). In phase 3 clinical trials (SURPASS 1-5), tirzepatide has been shown to achieve better glycaemic control in terms of glycosylated hemoglobin reduction (HbA1c) and improved fasting, postprandial glucose levels and weight reduction as compared to placebo and active comparators.  The SURPASS 4 clinical trial has shown positive cardiovascular outcomes in people with T2DM with elevated cardiovascular risk. Tirzepatide has acceptable side effects and is well tolerated, with a low risk of hypoglycaemia. Additionally, encouraging results from SURMOUNT trials and ongoing SURPASS-CVOT studies will shed more light on cardiovascular safety in the future. In this review, we have summarized the pharmacology, efficacy, safety, and clinical trials for potential impact for clinical treatment T2DM. 
Co-Authors Evo Elidar Harahap Lubis, Dian Anindita Lubis, Frihastina Lydia, Wika Muhammad Akbar Batubara Nasution, Melati Silvanni Pangaribuan, Jessica Patricia Siregar, Hafiz Syaifullah