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All Journal Nexus Kedokteran Translasional Open Access Indonesian Journal of Medical Reviews Journal of Anesthesiology and Clinical Research
Elanda Rahmat Arifyanto
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Efek Hepatoprotektor Ekstrak Tempe Kedelai pada Mencit (Mus musculus) yang Diinduksi Parasetamol Arifyanto, Elanda Rahmat; Widjokongko, S. Bambang; Sjarifah, Ipop
Nexus Kedokteran Translasional Vol 1, No 2 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Soybean tempeh is known to contain various kinds of antioxidants such as vitamin C, vitamin E, vitamin B2, saponins, isoflavones, phytic acid, lecithin, iron, and phytosterol. Antioxidants are thought to be hepatoprotective. The objective of this research is to know the influence of soybean tempeh extract to the liver histological damage of mice (Mus musculus) and the increase of soybean tempeh extract dose can also increase protection effect to the liver histological damage of mice (Mus musculus) which is induced by paracetamol.   Methods: This was laboratory experimental research with the post test only controlled group design. Samples were 32 male mice, Swiss webster type, 2-3 months old age and ± 20 g of each weight. Samples were divided into 4 groups of 8 mice each. Sampling technique used in this research was incidental sampling. Mice for control group (K) and P1 group will be given aquadest for 14 days in a row. The P2 and P3 group will be given soybean tempeh extracts dose for 14 days in a row. Soybean tempeh extracts dose in each group was 2.2 mg/20 g weight of mice and 4.4 mg/20 g weight of mice. Paracetamol will be given to P1, P2, and P3, with dose 5 mg/20g weight of mice on the 12th to 14th days. On the 15th day, hepar of mice was taken and stainned with Hematoxylin Eosin (HE) for histopathological study. The hepar cells of mice were observed microscopically by counting the number of necrosis cells on the centrolobuler zone. The data were analyzed by Oneway ANOVA test and Post Hoc test (α=0.05).   Results:The average damage of hepar cells in the K, P1, P2, P3 were 20.75 ± 1.58; 85.00 ± 2.98; 43.75 ± 2.92; 31.00±2.00consecutively. The results of Oneway ANOVA test showed a significant difference in all group (p < 0.05). The results of Post Hoc test showed significant differences between K – P1, K – P2, K – P3, P1 – P2, P1 – P3, and P2 – P3 with p < 0.05.   Conclusion: The soybean tempeh extracts can prevent the histological damage of the hepar cells of mice (Mus musculus) and the increase of soybean tempeh extracts dose followed by the increase of protection effect to the liver cell damaging of mice which is induced by paracetamol.   Key words: soybean tempeh extract, paracetamol, liver histological damaging.
Efek Hepatoprotektor Ekstrak Tempe Kedelai pada Mencit (Mus musculus) yang Diinduksi Parasetamol Elanda Rahmat Arifyanto; S. Bambang Widjokongko; Ipop Sjarifah
Nexus Kedokteran Translasional Vol 1, No 2 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.205 KB)

Abstract

Background: Soybean tempeh is known to contain various kinds of antioxidants such as vitamin C, vitamin E, vitamin B2, saponins, isoflavones, phytic acid, lecithin, iron, and phytosterol. Antioxidants are thought to be hepatoprotective. The objective of this research is to know the influence of soybean tempeh extract to the liver histological damage of mice (Mus musculus) and the increase of soybean tempeh extract dose can also increase protection effect to the liver histological damage of mice (Mus musculus) which is induced by paracetamol. Methods: This was laboratory experimental research with the post test only controlled group design. Samples were 32 male mice, Swiss webster type, 2-3 months old age and 20 g of each weight. Samples were divided into 4 groups of 8 mice each. Sampling technique used in this research was incidental sampling. Mice for control group (K) and P1 group will be given aquadest for 14 days in a row. The P2 and P3 group will be given soybean tempeh extracts dose for 14 days in a row. Soybean tempeh extracts dose in each group was 2.2 mg/20 g weight of mice and 4.4 mg/20 g weight of mice. Paracetamol will be given to P1, P2, and P3, with dose 5 mg/20g weight of mice on the 12th to 14th days. On the 15th day, hepar of mice was taken and stainned with Hematoxylin Eosin (HE) for histopathological study. The hepar cells of mice were observedmicroscopically by counting the number of necrosis cells on the centrolobuler zone. The data were analyzedby Oneway ANOVA test and Post Hoc test (?=0.05). Results:The average damage of hepar cells in the K, P1, P2, P3 were 20.75 1.58; 85.00 2.98; 43.75 2.92; 31.002.00consecutively. The results of Oneway ANOVA test showed a significant difference in all group (p < 0.05). The results of Post Hoc test showed significant differences between K P1, K P2, K P3, P1 P2, P1 P3, and P2 P3 with p < 0.05. Conclusion: The soybean tempeh extracts can prevent the histological damage of the hepar cells of mice (Mus musculus) and the increase of soybean tempeh extracts dose followed by the increase of protection effect to the liver cell damaging of mice which is induced by paracetamol. Key words: soybean tempeh extract, paracetamol, liver histological damaging.
Ultrasound-Guided Superficial Cervical Plexus Block for Anterior Cervical Discectomy and Fusion in a Patient with Herniated Nucleus Pulposus: A Case Report Elanda Rahmat Arifyanto; Aura Ihsaniar
Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 1 (2025): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v5i1.689

Abstract

Anterior cervical discectomy and fusion (ACDF) is a surgical procedure performed to alleviate pressure on the spinal cord and nerve roots in the neck. Effective pain management is crucial for optimal postoperative recovery. Superficial cervical plexus block (SCPB) has emerged as a safe and effective regional anesthesia technique for head and neck surgeries. This case report describes the successful use of ultrasound-guided SCPB for ACDF in a patient with a herniated nucleus pulposus. In this study, a 48-year-old male patient presented with lower extremity weakness and hypoesthesia following a fall. Magnetic resonance imaging (MRI) revealed a herniated nucleus pulposus at the C5-6 level. The patient underwent ACDF surgery under ultrasound-guided SCPB. Levobupivacaine 0.5% 10 cc was administered bilaterally. The patient tolerated the procedure well, with no complications or adverse events. Postoperative pain was effectively managed with SCPB, and the patient's neurological symptoms improved significantly. In conclusion, ultrasound-guided SCPB is a safe and effective anesthetic technique for ACDF surgery in patients with herniated nucleus pulposus. It provides adequate pain control, reduces opioid requirements, and facilitates early mobilization and recovery.
Opioid-Sparing Anesthesia: The Dual Efficacy of Ketamine on Postoperative Pain and Systemic Inflammation Following Spinal Surgery Elanda Rahmat Arifyanto; Ardana Tri Arianto; Heri Dwi Purnomo
Journal of Anesthesiology and Clinical Research Vol. 6 No. 2 (2025): Journal of Anesthesiology and Clinical Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/jacr.v6i2.804

Abstract

Introduction: Postoperative pain and inflammation after major spinal surgery, such as laminectomy, pose significant challenges to patient recovery and contribute to opioid consumption. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is proposed to have both analgesic and anti-inflammatory properties, positioning it as a key component of an opioid-sparing strategy. This study aimed to evaluate the clinical efficacy of a specific intraoperative ketamine infusion regimen compared to a continuous micro-dose morphine regimen on early postoperative pain and systemic inflammation. Methods: This prospective, double-blind, randomized controlled trial included 24 adult patients (ASA I-II) undergoing thoracolumbar laminectomy. Patients were randomly assigned to receive either a continuous intraoperative infusion of ketamine at 10 mcg/kg/minute (n=12) or morphine at 10 mcg/kg/hour (n=12). The primary outcomes were postoperative pain intensity, measured by the Visual Analog Scale (VAS) at 6 and 12 hours, and the systemic inflammatory response, assessed via high-sensitivity C-reactive protein (hs-CRP) levels measured preoperatively and 6 hours postoperatively. Results: The study groups were comparable regarding baseline demographic and surgical characteristics (p>0.05). At 6 hours postoperatively, the ketamine group reported significantly lower VAS pain scores than the morphine group (mean score of 2.33 ± 0.78 versus 3.83 ± 1.03, respectively; p=0.001). This difference was not maintained at 12 hours (p=0.646). Critically, the surgically-induced increase in hs-CRP was significantly attenuated in the ketamine group, which showed a mean increase of only 1.43 ± 1.04 mg/L from baseline, compared to a much larger increase of 2.88 ± 1.06 mg/L in the morphine group (p=0.003). Conclusion: An intraoperative ketamine regimen of 10 mcg/kg/minute is more effective at reducing pain in the immediate 6-hour postoperative period and mitigating the systemic inflammatory response than a continuous micro-dose morphine regimen. These findings underscore ketamine's potent dual-mechanism action, targeting both nociceptive and inflammatory pathways, and strongly support its use in multimodal, opioid-sparing protocols for spinal surgery.
Co-Authors Ardana Tri Arianto Aura Ihsaniar Heri Dwi Purnomo Ipop Sjarifah Ipop Sjarifah S. Bambang Widjokongko