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All Journal Biotropika Berita Biologi
Ewaldo, Muhammad Farrel
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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In silico Exploration of Phospholipase A2 Inhibitor Compounds from Lufariella variabilis as Antivenom of Ophiophagus hannah Dion, Romario; Ewaldo, Muhammad Farrel; Fauzaan, Muhammad Faishal; Wandi, Ilham Aris; Asih, Rina Sari
Biotropika: Journal of Tropical Biology Vol. 10 No. 1 (2022)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2022.010.01.06

Abstract

The King Cobra (Ophiophagus hannah) is a venomous snake found in Southeast Asia and South Asia. Globally, it is estimated that there are 81,000 to 138,000 cases of snakebite deaths from 1.8 million to 2 million snakebite cases. The limited availability of antivenom is a problem in handling snake venom poisoning. Exploration of natural ingredients is needed as a preventive measurement from the spread of toxins when they are inside the body. Exploration could be carried out by utilizing natural metabolite compounds that can be inhibitors of the phospholipase A2 (PLA2) enzyme. Luffariella variabilis is known as a marine organism that can produce sesterterpenoid compounds and has the potential as an inhibitor of the phospholipase A2 enzyme. This study aims to explore the potential of sesterterpenoid compounds produced by Luffariella variabilis as an in silico inhibitor of phospholipase A2. Several methods used in this research are molecular docking simulation, toxicity test using pkCSM and Toxtree, and chemical bond analysis using Discovery Studio. The results showed that the manoalide compound was the most potent compound of the other sesterterpenoid compounds in its ability to become a snake antivenom candidate.
STUDY OF TB STATUS IN INDONESIA AND ENDOPHYTIC ACTINOMYCETES AS POTENTIAL SOURCE OF NATURAL PRODUCT FOR ANTI-TUBERCULOSIS DRUG RESISTANCE Ewaldo, Muhammad Farrel; Rukmana, Andriansjah; Nurkanto, Arif
Berita Biologi Vol 23 No 3 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2024.6267

Abstract

Tuberculosis, caused by Mycobacterium tuberculosis, is a significant contributor to global mortality, being responsible for one of the primary causes of death worldwide. The current problem is antibiotic resistance in the treatment of tuberculosis patients, which causes the decreasing effectiveness of drugs for tuberculosis therapy. Therefore, exploration for finding new drugs is still necessary. Actinomycetes represent a group of microbes known for producing bioactive compounds, particularly in the form of antibiotics. This microbe can be found associated with plants as endophytic actinomycetes may have the same or similar secondary metabolites as their host. In certain instances, metabolites generated by endophytic actinomycetes exhibit uniqueness and hold the potential to combat antibiotic-resistant pathogenic microbes effectively. This review focuses on new ideas for exploring the potential of endophytic actinomycetes from medicinal plants, especially in Indonesia, considering existing tuberculosis conditions using reviews from scientific sources such as scientific journals, case reports, official government websites, and tuberculosis drug development. This review was then compiled and created a new idea to explore endophytic actinomycetes from medicinal plants in Indonesia using validated methods and contemporary research.
Co-Authors . Andriansjah Arif Nurkanto Asih, Rina Sari Dion, Romario Fauzaan, Muhammad Faishal Wandi, Ilham Aris