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Anggunan
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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HUBUNGAN KADAR HbA1c DENGAN KADAR KREATININ SERUM PADA PENDERITA DIABETES MELITUS TIPE 2 DI RUMAH SAKIT PERTAMINA BINTANG AMIN HUSADA BANDAR LAMPUNG TAHUN 2022 Zulfian; Anggunan; Vica Sukma; Syuhada
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.362

Abstract

Diabetes mellitus occurs due to disturbances in the body's metabolism that causes hyperglycemia and is associated with abnormalities of work and/or insulin secretion. One of the complications of type 2 diabetes mellitus is diabetic nephropathy which can be diagnosed early by measuring creatinine levels. Correlative analytic research with cross sectional method uses purposive sampling technique. The study sample consisted of 30 patients with type 2 diabetes with HbA1c levels <7% percentage (26.7%) and HbA1c levels 7% percentage (73.3%). For serum creatinine levels, serum creatinine values ​​were <1.1mg/dl percentage (23.3%) and serum creatinine values ​​1.1mg/dl percentage (76.7%). The results of the chi square test showed p value = 0.037 and odd ratio value (CI 95%) 6.3333 because the p value = 0.037 < 0.05 there was a relationship between HbA1c levels and serum creatinine levels in patients with type 2 diabetes. Odd ratio 6.3333 which means high HbA1c levels height 6.3 times higher is a factor in the increase in serum creatinine levels in patients with type 2 diabetes at Pertamina Bintang Amin Husada Hospital Bandar Lampung in 2022.
Efektifitas Antibiotik Klindamicin Terhadap Bakteri Propionibacterium Acnes Dengan Metode Difusi Pada Pasien Acne Vulgaris Muhamad Syafei Hamzah; Arief Effendi; Eka Silvia; Anggunan; Ade Utia; Zulhafiz Mandala; Marina Ayu Ningsri; Alvin Andrian Susanto; Muhammad Kevin Wiratama
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.353

Abstract

Acne vulgaris (AV) is defined as a skin disease caused by chronic inflammation of the pilosebaceous unit consisting of non-inflammatory lesions such as open comedones and closed comedones with inflammatory lesions in the form of papules, pustules, and nodules. Tetracycline has a very strong inhibitory power against Propionibacterium acne bacteria. This study aims to compare the effectiveness of the antibiotics clindamycin, benzoyl peroxide, erythromycin, azelac acid and Lactobacillus achidopillus with the effectiveness of tetracycline against Propionibacterium acnes. Research on the effectiveness of tetracycline antibiotics against Propionibacterium acnes was carried out in vitro using the disc diffusion method on Mueller-Hinton Agar media and analyzed the data using Shapiro-wilk for data normality. After being declared to be normally distributed (p>0.05), an unpaired T-test was performed. If the data obtained were not normally distributed, the Mann-Whitney test was performed to test the ratio 1 and 2. The mean effectiveness of tetracycline antibiotics was 48.7 mm and placebo/ vaseline of 0 mm against Propionibacterium acnes in vitro. Based on the unpaired T-Test, Sig.(2-Tailed) = 0.000 (p<0.05) was obtained, which means that there is a significant difference in each variable. There are differences in the effectiveness of Tetracycline antibiotics with placebo/vaseline on the growth of Propionibacterium acnes using the in vitro diffusion method.  
HUBUNGAN KEBERSIHAN WAJAH TERHADAP KEJADIAN AKNE VULGARIS PADA MAHASISWI FAKULTAS KEDOKTERAN UNIVERSITAS MALAHAYATI ANGKATAN 2018 Amalia Shofifah Anggraeni; Rakhmie Rafie; Anggunan; M. Syafei Hamzah
Medula Vol 12 No 3 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i3.356

Abstract

Acne vulgaris (AV) is a chronic inflammatory disease of pilosebaceous follicles that can heal itself with multifactorial causes and has several clinical features in the form of acne, comedones, papules, pustules, nodes, and cysts. Factors causing the appearance of acne vulgaris are usually influenced by bacterial infection, excessive use of cosmetics, hormones and lack of hygiene. Performing facial hygiene can reduce bacteria or microorganisms from the skin surface by reducing sebum and dirt without removing the lipid barrier of the skin so as to reduce AV symptoms
Symptom-Based Management of Chronic Gastroesophageal Reflux Disease in a Young Adult: A Holistic Therapeutic Approach Leokrisnha, Rhomy; Anggunan; Ijlal, M Raihan Raid; Nisa, Maisa Aqila Fazilatun; Hr, Marisha Alsahda; Regar, Mely Shanrina Br; Putri, Mentari Kusuma
Biomedical Research and Theory Letters Vol. 1 No. 2 (2025): Biomedical Research and Theory Letters
Publisher : CV. FOUNDAE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58524/brtl.v1i2.72

Abstract

Gastroesophageal Reflux Disease (GERD) is a chronic gastrointestinal disorder resulting from the retrograde movement of gastric contents into the esophagus, often due to lower esophageal sphincter dysfunction. It is characterized by hallmark symptoms such as heartburn, regurgitation, epigastric pain, and may also present with extra-esophageal manifestations including chronic cough, hoarseness, or dental erosion. GERD significantly affects quality of life and, if left untreated, may lead to complications such as esophagitis, strictures, or Barrett’s esophagus. This case report presents a 21-year-old female with a history of recurrent GERD symptoms since childhood. She presented with complaints of persistent epigastric pain, nausea, and a burning sensation in the chest, particularly after meals. Physical examination revealed epigastric tenderness and clinical signs suggestive of anemia, including pallor and fatigue. A detailed clinical history and symptom pattern strongly supported a diagnosis of GERD. Given the classic presentation and absence of alarm features, a non-invasive, symptom-based diagnostic approach was adopted, avoiding the need for endoscopy or pH monitoring. The patient was managed with a combination of pharmacological therapy omeprazole (a proton pump inhibitor), antacids for symptomatic relief, paracetamol for pain management, and vitamin B6 to address nutritional deficiencies. Additionally, lifestyle modifications were emphasized, including dietary regulation, avoidance of trigger foods (such as spicy and acidic items), elevation of the head during sleep, and meal timing adjustments. Within one week of initiating treatment, the patient reported significant improvement in symptoms, with reduced frequency and intensity of heartburn and nausea. This case highlights the importance of early recognition and comprehensive management of GERD, especially in young adults with a chronic history of symptoms. It underscores the effectiveness of combining pharmacological treatment with lifestyle interventions and demonstrates that a symptom-based, non-invasive approach can be both practical and effective in primary care settings. Patient education and adherence to therapy remain critical in preventing recurrence and improving long-term outcomes.
Co-Authors Ade Utia Alvin Andrian Susanto Amalia Shofifah Anggraeni Arief Effendi Eka Silvia Hr, Marisha Alsahda Ijlal, M Raihan Raid Leokrisnha, Rhomy M. Syafei Hamzah Marina Ayu Ningsri Muhamad Syafei Hamzah Muhammad Kevin Wiratama Nisa, Maisa Aqila Fazilatun Putri, Mentari Kusuma Rakhmie Rafie Regar, Mely Shanrina Br syuhada Vica Sukma Zulfian Zulhafiz Mandala