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All Journal Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biological Pharmacy
Mei, Kaila Keyshia
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Artikel Review: Aktivitas Imunomodulator Tanaman dari Suku Asteraceae Mei, Kaila Keyshia; Iskandar, Yoppi
Indonesian Journal of Biological Pharmacy Vol 2, No 1 (2022): IJBP (April)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v2i1.38128

Abstract

Imunitas merupakan suatu reaksi pertahanan tubuh terhadap bahan asing, terdapat suatu kondisi dimana sistem imun dapat terganggu sehingga menyebabkan penyakit seperti autoimun, alergi, dan imunodefisiensi. Saat ini terdapat obat sintetik yang dapat mengobati kelainan imun, tetapi obat sintesik memiliki efek samping. Sehingga diperlukan pengobatan alternatif yang penggunaannya dinilai lebih aman. Asteraceae merupakan suku tumbuhan terbesar kedua dalam kingdom Plantae yang tersebar luas di seluruh dunia. Penulisan artikel ini bertujuan untuk memberikan informasi ilmiah beberapa tanaman dari suku Asteraceae yang memiliki aktivitas imunomodulator. Metode yang digunakan dengan cara pencarian pada aplikasi Google Chrome secara daring yang berasal dari Google Scholar, PubMed, ResearchGate, situs jurnal lain. Terdapat beberapa tanaman suku Asteraceae yang memiliki aktivitas imunomodulator diantaranya Ageratum Conyzoides (L.); Artemisia annua L.; Artemisia argyi H. Lev. & Vaniot; Baccharis dracunculifolia DC.; Chromolaena odorata (Lf.) King & Robinson; Cichorium intybus L.; Cynara scolymus L.; Echinacea laevigata (C. L. Boynt. & Beadle) S.F. Blake; Echinacea purpurea (L.) Moench; Echinacea purpurea (L.) Moench; Erigeron floribundus (Kunth) Sch.Bip.; Psacalium peltatum (Kunth) Cass.; Tanacetum parthenium (L.) Sch.Bip.; Tridax procumbens L.Kata kunci: Asteraceae, Imunomodulator, Sistem imun
In Silico Study of Compounds in Bawang Dayak (Eleutherine palmifolia (L) Merr.) Bulbs on Alpha Estrogen Receptors Sunani, Sunani; Andani, Maya; Kamaludin, Asilla Mauri Ramdini; Helmi, Nyai Ayu Sylfia Stannia Puspitasari; Mei, Kaila Keyshia; Guspira, Yunitasya; Sabetta, Oktavia; Aulifa, Diah Lia
Indonesian Journal of Cancer Chemoprevention Vol 13, No 2 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss2pp83-93

Abstract

Breast cancer is an uncontrolled malignancy of the breast that originates from glandular cells, gland ducts, and the supporting tissues of the breast. The development of herbal-based anticancer drugs is progressing, one of which is derived from the natural ingredients of Eleutherine palmifolia tubers. The aim of this study was to determine the activity of compounds derived from Eleutherine palmifolia tubers on the alpha-estrogen receptor (ERα) using an in silico study. The crystal structure of the enzyme used was 3ERT which was obtained from the Protein Data Bank (PDB). The applications used in this journal are Chem3D (initial preparation of ligands and receptors), AutoDock4 (redocking and calculation of root mean square deviation (RSMD)), and Biovia (visualization of redocking results). Tamoxifen was used as a reference ligand. Based on the results of the in silico study, the best compound that has the potential to be developed as a candidate for anticancer drug is Eleutherine because the results of the in silico test on Eleutherine have a value of G=-7.56 kkal/mol and the smallest KI=2.89 nM, so it can be concluded that eleutherine is one of potential drug candidate for anti cancer.Keywords: Breast cancer, eleutherine, estrogen receptor α.
Co-Authors Diah Lia Aulifa Guspira, Yunitasya Helmi, Nyai Ayu Sylfia Stannia Puspitasari Kamaludin, Asilla Mauri Ramdini Maya Andani, Maya Sabetta, Oktavia Sunani, Sunani Yoppi Iskandar