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All Journal Farmaka Indonesian Journal of Cancer Chemoprevention
Guspira, Yunitasya
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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REVIEW ARTIKEL: STUDI KOMPARASI EFEKTIVITAS PENGGUNAAN PHOSPHATE BINDER PADA PENGOBATAN PASIEN CHRONIC KIDNEY DISEASE (CKD) Guspira, Yunitasya; Syah, Insan Sunan Kurniawan
Farmaka Vol 21, No 2 (2023): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v21i2.46876

Abstract

Chronic Kidney Disease (CKD) atau penyakit ginjal kronis merupakan penyakit yang mengalami kenaikan jumlah kasus serta dianggap permasalahan yang gawat. Kondisi CKD menyebabkan gangguan keseimbangan elektrolit seperti hiperfosfatemia. Hiperfosfatemia didefinisikan sebagai gangguan metabolisme mineral pada pasien CKD. Fosfat adalah jenis mineral yang sering terganggu metabolismenya diantara komplikasi CKD yang perlu menjadi perhatian khusus karena berperan tinggi pada morbiditas dan mortalitas. Tulisan ini bertujuan untuk menelaah perbandingan efektivitas adanya terapi tambahan phosphate binder ke dalam regimen pengobatan CKD. Metode yang digunakan adalah penelaahan beberapa literatur melalui Google Scholar dan Pubmed mengenai literatur atau tulisan yang menjelaskan penambahan phosphate binder pada pasien CKD. Disimpulkan bahwasanya phosphate binder yang paling efektif dengan dilihat dari penurunan kadar fosfat yang signifikan yaitu sevelamer, namun tetap dikembalikan terhadap kondisi individu.Kata Kunci: Chronic Kidney Disease (CKD), hiperfosfatemia, phosphate binder
In Silico Study of Compounds in Bawang Dayak (Eleutherine palmifolia (L) Merr.) Bulbs on Alpha Estrogen Receptors Sunani, Sunani; Andani, Maya; Kamaludin, Asilla Mauri Ramdini; Helmi, Nyai Ayu Sylfia Stannia Puspitasari; Mei, Kaila Keyshia; Guspira, Yunitasya; Sabetta, Oktavia; Aulifa, Diah Lia
Indonesian Journal of Cancer Chemoprevention Vol 13, No 2 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss2pp83-93

Abstract

Breast cancer is an uncontrolled malignancy of the breast that originates from glandular cells, gland ducts, and the supporting tissues of the breast. The development of herbal-based anticancer drugs is progressing, one of which is derived from the natural ingredients of Eleutherine palmifolia tubers. The aim of this study was to determine the activity of compounds derived from Eleutherine palmifolia tubers on the alpha-estrogen receptor (ERα) using an in silico study. The crystal structure of the enzyme used was 3ERT which was obtained from the Protein Data Bank (PDB). The applications used in this journal are Chem3D (initial preparation of ligands and receptors), AutoDock4 (redocking and calculation of root mean square deviation (RSMD)), and Biovia (visualization of redocking results). Tamoxifen was used as a reference ligand. Based on the results of the in silico study, the best compound that has the potential to be developed as a candidate for anticancer drug is Eleutherine because the results of the in silico test on Eleutherine have a value of G=-7.56 kkal/mol and the smallest KI=2.89 nM, so it can be concluded that eleutherine is one of potential drug candidate for anti cancer.Keywords: Breast cancer, eleutherine, estrogen receptor α.
Co-Authors Diah Lia Aulifa Helmi, Nyai Ayu Sylfia Stannia Puspitasari Kamaludin, Asilla Mauri Ramdini Maya Andani, Maya Mei, Kaila Keyshia Sabetta, Oktavia Sunani, Sunani Syah, Insan Sunan Kurniawan