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All Journal Humantech : Jurnal Ilmiah Multidisiplin Indonesia Pharmacy Reports
Mahaswari, Anak Agung Istri Rani
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Religion Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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In silico molecular docking of quercetin as anti-colorectal cancer agents by inhibiting LT4AH Saputra, Made Agus Widiana; Mahaswari, Anak Agung Istri Rani; Anggreni, Ni Ketut Sri; Putri, Wahyu Nadi Eka; Laksmiani, Ni Putu Linda
Pharmacy Reports Vol. 1 No. 2 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.564 KB) | DOI: 10.51511/pr.16

Abstract

Colorectal cancer is a malignant neoplasm originating from the colon or rectum. Overexpression of leukotriene A4 hydrolase (LTA4H) increases the growth of HCT116 colon cancer cells, therefore, this enzyme becomes an attractive target for commercial drug bestatin. Meanwhile, quercetin is a member of flavonoids possessing a wide variety of anticancer. This study aimed to determine the potential of quercetin as anti-colorectal cancer by inhibiting LTA4H through in silico molecular docking. The docking process involved optimizing quercetin structure, preparing LTA4H protein (PDB ID: 3U9W), validating the molecular docking method, and docking quercetin and bestatin on LTA4H. The binding energy of quercetin to LTA4H was -9.57 kcal/mol, while 28P native ligand and bestatin yielded -10.22 kcal/mol and -9.10 kcal/mol, respectively. Based on the binding energy value, quercetin has a potential inhibitory against the LTA4H.
Review: profil disolusi dan media disolusi yang baik pada tablet rifampicin Mahaswari, Anak Agung Istri Rani; I Gusti Ngurah Agung Dewantara Putra; Eka Indra Setyawan
Humantech : Jurnal Ilmiah Multidisiplin Indonesia Vol. 2 No. 3 (2022): Humantech : Jurnal Ilmiah Multidisiplin Indonesia
Publisher : Program Studi Akuntansi IKOPIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32670/ht.v2i3.1438

Abstract

The development of generic drug consumption in Indonesia is relatively slow. This is because generic drugs are still underestimated by stakeholders for various reasons, the most classic and fundamental is quality. So it is necessary to test the dissolution rate of a drug preparation, so that the dissolution test can be a method to prove the quality of a preparation including generic and branded rifampicin tablets. Objective: To find out how the good dissolution profile onrifampicin tablets branded and with the logo and to find out how good the invivo and in-vitro correlation coefficient values are on the dissolution media. Results: There is no significant difference in DE45 between branded and generic rifampicin tablets, so the results obtained indicate that the brand and generic rifampicin tablets have the same efficacy and quality. Conclusion: The greater the dissolution time, the higher the dissolved rifampicin level. Where the DE45 value indicates the speed of drug dissolution into the medium approaching the in vivo drug absorption profile. The results show that there is no significant difference in DE45 between branded and generic rifampicin tablets, so that the results obtained indicate that the brand and generic rifampicin tablets have the same efficacy and quality. The data show a good correlation with the yield obtained from the dissolution medium containing 0.4% (w/v) sodium lauryl sulfate. Furthermore, the in vitro-in vivo correlation value obtained from the 0.4% (w/v) sodium lauryl sulfate solution medium was in accordance with the in vivo correlation coefficient. Then the 0.4% (w/v) sodium lauryl sulfate solution is a suitable dissolution medium for the fixed dose combination of rifampicin-isoniazid.
Co-Authors Anggreni, Ni Ketut Sri Eka Indra Setyawan I Gusti Ngurah Agung Dewantara Putra Ni Putu Linda Laksmiani Putri, Wahyu Nadi Eka Saputra, Made Agus Widiana