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All Journal Farmaka Indonesian Journal of Cancer Chemoprevention Journal Of Vocational Health Studies
Isman, Hasna Siti Munifah
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Studi Literatur: Penggunaan Antihistamin Dalam Terapi Kondisi Alergi Pada Masa Kehamilan Isman, Hasna Siti Munifah; Iskandar, Yoppi
Farmaka Vol 21, No 3 (2023): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v21i3.47338

Abstract

Antihistamin merupakan salah satu obat yang paling umum digunakan selama kehamilan dimana sekitar 10-15% wanita menggunakan obat antihistamin untuk meredakan mual dan muntah, serta gejala alergi selama masa kehamilannya. Pemilihan dan penggunaan obat-obatan pada masa kehamilan termasuk obat antihistamin dalam manajemen kondisi alergi perlu memperhatikan serta mempertimbangkan berbagai aspek, terutama terkait keamanannya baik bagi ibu maupun janin. Tujuan studi literatur ini yaitu untuk membahas terkait obat antihistamin sebagai terapi kondisi alergi, penggunaannya pada masa kehamilan, serta profil keamanannya bagi wanita hamil dengan mengumpulkan data dan informasi melalui pencarian literatur jurnal penelitian yang diakses secara daring melalui laman database Google Scholar, PubMed, dan Sciencedirect. Antihistamin generasi kedua lebih disukai dari generasi pertama baik pada pasien hamil maupun tidak hamil. Cetirizine atau loratadine lebih direkomendasikan berdasarkan pada data keamanan yang sangat baik dan telah direkomendasikan dalam banyak pedoman untuk kondisi alergi selama kehamilan, namun dengan tetap mempertimbangkan rasio risiko/manfaat bagi ibu dan kehamilannya.
POTENCY OF CHLORELLA SPP. AS AN ANTIOXIDANT AND ANTI-INFLAMMATORY AGENT Cahyani, Fauzia Rahma; Isman, Hasna Siti Munifah
Journal of Vocational Health Studies Vol. 5 No. 3 (2022): March 2022 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V5.I3.2022.203-211

Abstract

Background: Chlorella is a natural marine product that belongs to the type of unicellular green microalgae which is currently widely used as an alternative therapy because of its secondary metabolite content which has various benefits with minimal side effects. Chlorella has also been widely studied for activities such as being an antioxidant and anti-inflammatory agent that plays a role in prevention and treatment. Purpose: This literature review aims to dig up information about the potency of Chlorella as an antioxidant and anti-inflammatory agent based on several previous studies. Review: Based on the online existing literature from the PubMed and Google Scholar databases, the results of studies on the potential of Chlorella as an antioxidant and anti-inflammatory agent were analyzed. Based on the literature review, Chlorella can act as an antioxidant and anti-inflammatory agent due to the phenolic compounds, carotenoid pigments and chlorophyll, and extracellular polysaccharides (EPS) contained in it. Conclusion: Chlorella has antioxidant and anti-inflammatory activity and has the potential to prevent and treat several types of diseases.
In Silico Study of Chemical Compounds in Plantago major L. as Anti-Androgen Baihaqi, Achmad Al; Isman, Hasna Siti Munifah; Fauziyyah, Ganis Fitria; Hutabarat, Rismauli Ruth Natasari; Hartono, Adi; Megantara, Sandra
Indonesian Journal of Cancer Chemoprevention Vol 13, No 1 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss1pp33-45

Abstract

Prostate cancer is the most common type of cancer diagnosed in men worldwide and the second leading cause of death after lung cancer. Testosterone and dihydrotestosterone (DHT) have been known to play an essential role in prostate cancer. Androgen receptor (AR) binding to the ligand allows homodimerization and translocation to the nucleus, which acts as a transcription factor for androgen-responsive genes such as PSA (Prostate-specific antigen). Although many anti-androgens have been established, including Bicalutamide, Flutamide, and Abiraterone, the problem of non-specific cytotoxicity effects and cancer recurrence due to potential drug resistance remains a significant obstacle to establishing effective therapy. Plantago major L. is one of the plants that can choose anticancer therapy because, based on reports, it has anticancer activity through DNA damage in cancer cells. This study focused on the search for the potential phytochemical activity of Plantago major L. as an anti-androgen, non-cytotoxic, and had significant AR inhibitory activity. This study uses Lipinski prediction (RO5), ADMET prediction, and a structure-based approach with molecular docking techniques using the PDB ID 2AM9 receptor structure and 13 compounds from Plantago major L. as test ligands compared to known AR antagonists. From the research results, Hispidulin has the highest potential as an anti-androgen with binding energy (-9.43 kcal/mol) that is closest to natural ligands and is smaller than Flutamide as a comparison drug. This anti-androgen activity was hypothesized from the similarity of hydrogen bonds with amino acid residues 705-Asn and 711-Gln as key AR residues present in Hispidulin.Keywords: Prostate cancer, Androgen Receptor, Plantago major L., ADMET, In Silico.
Co-Authors Baihaqi, Achmad Al Cahyani, Fauzia Rahma Fauziyyah, Ganis Fitria HARTONO, ADI Hutabarat, Rismauli Ruth Natasari Megantara, Sandra Yoppi Iskandar