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All Journal Journal of Tropical Pharmacy and Chemistry
Ramadhani, Agung
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Synthesis and Toxicity Tests of N-Carbothioamide-3-(2,4- Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl)Pyrazoline Irfan, Muhammad; Meylina, Lisna; Ramadhani, Agung; Rusli, Rolan
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 1 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i1.612

Abstract

Pyrazoline is an alkaloid compound which has various biological activities such as antibacterial, antifungal, antitumor and anticancer. The compound N-carbotioamide-3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl)pyrazoline was successfully synthesized from the basic ingredients 2',4'-dichloro-4-hydroxy-3-methoxychalcone and thiosemicarbazide with sodium hydroxide catalyst at 80°C for 7 hours. The synthesized compound was characterized using 1H-NMR, 13C-NMR, and mass spectroscopy and had a yield of 28.03%. Based on the results of toxicity tests using the Brine Shrimp Lethality Test (BSLT) method, this compound has an LC50 value of 44.6 ppm and has the potential to be an antimicrobial compound.
Co-Authors Meylina, Lisna Muhammad Irfan Rusli, Rolan