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All Journal Inovasi Fisika Indonesia (IFI) Farmasis: Jurnal Sains Farmasi
Amalia, Dilla
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Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Electrical & Electronics Engineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Efek Neuroprotektif Fraksi Air Daun Semanggi (Marsilea crenata Presl.) secara In Vitro Burhan Ma'arif; Muslim, Menara; Riyanti, Anisa Eka; Guhir, Abdul Malik; Amalia, Dilla; Saidah, Nisfatul Lailatus; Anggraini, Wirda; Atmaja, Ria Ramadhani Dwi; Laswati, Hening; Agil, Mangestuti
FARMASIS: Jurnal Sains Farmasi Vol 2 No 1 (2021): Farmasis : Jurnal Sains Farmasi
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v2i1.3537

Abstract

Background: Estrogen deficiency can trigger several diseases, one of which is neurodegenerative. Neurodegenerative begins with neuroinflammation, which triggers the activation of microglia cells resulting in a pro-inflammatory activity. Potential and relatively safe therapy to use to overcome it is by using phytoestrogen compounds. Marsilea crenata Presl. is a plant that contains phytoestrogens. Objective: The purpose of this study was to analyze the neuroprotective effect of the water fraction of Marsilea crenata Presl. leaves which was shown by inhibition of neuroinflammation and marked by increased levels of MHC II against HMC3 microglia cells. Methods: IFN-γ is induced into HMC3 microglia cells for 24 hours to cause inflammatory conditions. Marsilea crenata Presl. leaves water fraction was given at a dose of 62,5; 125; and 250 µg / ml. Analysis of the neuroprotective effect of HMC3 microglia cells using the ICC method with the aid of the CLSM instrument. Results: The results of this study indicate that the water fraction of Marsilea crenata Presl. leaves can reduce MHC II expression at concentrations of 125 and 250 μg / ml with values ​​of 465,748 and 460,884 AU at p less than 0,005. Conclusion: This study concludes that the water fraction of Marsilea crenata Presl. has neuroprotective activity shown at doses of 125 and 250 μg/ml which can reduce MHC II expression in HMC3 microglia cells induced by IFN-γ. The ED50 value which has a neuroprotective effect is at a dose of 0,582 μg/ml.  
UNJUK KERJA KOMPOSIT TIO₂/PANI UNTUK DEGRADASI PEWARNA METHYLENE BLUE Amalia, Dilla; Putri, Nugrahani Primary
Inovasi Fisika Indonesia Vol. 14 No. 2 (2025): Vol 14 No 2
Publisher : Prodi Fisika FMIPA Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ifi.v14n2.p234-242

Abstract

Abstrak Pencemaran air akibat limbah industri, khususnya dari zat pewarna sintetis seperti methylene blue, merupakan masalah lingkungan signifikan yang memerlukan solusi efektif dan berkelanjutan. Fotokatalisis berbasis semikonduktor telah banyak dikembangkan sebagai metode efisien untuk degradasi polutan. Penelitian ini mengkaji sintesis nanopartikel titanium dioksida (TiO₂) dan pembentukan komposit TiO₂/polianilin (PANI) melalui metode polimerisasi in situ. Rancangan penelitian mencakup proses sintesis, karakterisasi struktur dan gugus fungsi menggunakan XRD, FTIR, dan spektrofotometri UV-Vis, serta pengujian aktivitas fotokatalitik terhadap degradasi methylene blue. Hasil menunjukkan bahwa komposit TiO₂/PANI memiliki fasa anatase dominan berdasarkan analisis XRD, serta keberadaan gugus fungsi khas PANI dan interaksinya dengan TiO₂ yang terkonfirmasi melalui spektrum FTIR. Uji fotokatalitik memperlihatkan efisiensi degradasi larutan methylene blue mencapai 98,94% pada 60 menit penyinaran UV dan meningkat hingga 99,69% setelah 180 menit, menandakan aktivitas fotokatalitik yang cepat dan hampir mencapai kondisi optimum. Temuan ini mengindikasikan potensi tinggi komposit TiO₂/PANI sebagai fotokatalis efektif untuk pengolahan limbah zat pewarna secara efisien dan berkelanjutan. Abstract Water pollution caused by industrial waste, particularly from synthetic dyes such as methylene blue, is a significant environmental issue that requires effective and sustainable solutions. Semiconductor-based photocatalysis has been extensively developed as an efficient method for pollutant degradation. This study investigates the synthesis of titanium dioxide (TiO₂) nanoparticles and the formation of TiO₂/polyaniline (PANI) composites via in situ polymerization. The research design includes synthesis processes, structural and functional group characterization using XRD, FTIR, and UV-Vis spectrophotometry, as well as photocatalytic activity testing for methylene blue degradation. Results indicate that the TiO₂/PANI composite predominantly exhibits the anatase phase as confirmed by XRD analysis, along with characteristic PANI functional groups and their interaction with TiO₂ verified by FTIR spectra. Photocatalytic tests demonstrated a degradation efficiency of 98.94% after 60 minutes of UV irradiation, which further increased to 99.69% after 180 minutes, indicating rapid photocatalytic activity approaching an optimal condition. These findings suggest that the TiO₂/PANI composite holds great potential as an effective photocatalyst for the efficient and sustainable treatment of dye-containing wastewater.
Co-Authors Burhan Ma'arif Guhir, Abdul Malik Hening Laswati Mangestuti Agil Muslim, Menara Nugrahani Primary Putri Ria Ramadhani Dwi Atmaja Riyanti, Anisa Eka Saidah, Nisfatul Lailatus Wirda Anggraini