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All Journal Majalah Obat Tradisional Journal of Islamic Pharmacy Pharmacology and Clinical Pharmacy Research Jurnal Mandala Pharmacon Indonesia Jurnal Kesehatan Masyarakat Mulawarman (JKMM) Farmasis: Jurnal Sains Farmasi Journal of Nursing Science Update
Ria Ramadhani Dwi Atmaja
Program Studi Farmasi, Fakultas Kedokteran Dan Ilmu Kesehatan, UIN Maulana Malik Ibrahim Malang, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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THE EFFECT OF ADMINISTERING RHIZOME EXTRACT OF CURCUMA (Curcuma Xanthorrhiza Roxb.) AT VARIOUS DOSES ON THE THICKNESS OF VAGINAL EPITHELIUM IN MICE (Mus Musculus) EXPOSED TO MSG Atmaja, Ria Ramadhani Dwi
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4249

Abstract

The usage of Monosodium Glutamate (MSG) as flavour enhancer in food is increasing and has reached alarming condition. Excessive consumption of MSG results in the formation of a number of free radicals in the body and affects the function of hypothalamus. A disturbed hypothalamus results in the decline of estrogen levels, and in turn, this estrogen deficiency causes a decrease in vaginal epithelial proliferation in which epithelial cells become thinner. Giving antioxidants might help to address these problems. One of the plants that is rich in antioxidant and grow in mass in Indonesia is curcuma. This study is aimed at analyzing the effect of giving curcuma extract (Curcuma Xanthorrhiza Roxb.) with varying doses on the thickness of vaginal epithelium in mice that are exposed to MSG. The research design employed in the study is true experimental posttest only control group by using 5 groups, namely: K1 (CMC-Na), K2 (MSG), P1 (MSG + curcuma rhizome extract dose of 0,4mg/gr BW), P2 (MSG + curcuma rhizome extract dose of 0,8mg/gr BW), P3 (MSG + curcuma rhizome extract dose of 1,2mg/gr BW). Vagina of each mouse was taken and studied to measure its epithelial thickness by using a 40x magnification on Olympus micrograph microscope. Data were then analyzed using One Way ANOVA. The results show that there is no significant difference in the thickness of vaginal epithelium in each treatment (ρ-value 0.341). Therefore, it can be concluded that the extract of curcuma rhizome does not have a significant influence on the thickness of vaginal epithelium in mice that are exposed to MSG. Keywords : MSG, Curcuma Xanthorrhiza, epithelium, vagina.
PHARMACIST COUNSELING EFFECT TO THE LEVEL OF PATIENT KNOWLEDGE WITH TYPE 2 DIABETES MELLITUS IN “KIMIA FARMA KAWI” PHARMACY, MALANG CITY Hakim, Abdul; Atmaja, Ria Ramadhani Dwi; Sugihantoro, Hajar; Mufidah, Fahda Dina
Journal of Islamic Pharmacy Vol 2, No 2 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i2.4507

Abstract

Diabetes mellitus is a carbohydrates, fats, protein metabolism disorder that caused by impaired insulin secretion, insulin disruption or both. Diabetes mellitus sufferer need a special care to make the blood glucose level always in normal condition and no complications in various organs. Type 2 diabetes mellitus is inception of disease begins with development of key metabolic abnormality, insulin resistance. Causes of type 2 diabetes mellitus is obesity, age over 40, lifesyle, genetic suscetibility. Pharmacist counseling to the patients of type 2 diabetes mellitus is very important because it can improve patient knowledge, patient compliance to the treatment and the quality of patients life. The purpose of this study is to determine the effect of counseling by pharmacists to the level of patient’s knowledge of type 2 diabetes mellitus in “Kimia Farma Kawi” Pharmacy, Malang City.This research is a quantitative study with Pre-Experimental design in the form of pretest – post-test design. Number of samples was taken during one month by using consecutive sampling method. The result of this study was using through Wilcoxon test that there was difference of value before and after the pharmacist counseling the patients of type 2 diabetes mellitus with significance value equal to 0.000 (p value 0,05). The conclusion of this research is the pharmacist counseling can improve patient knowledge of type 2 diabetes mellitus. Keywords : pharmacist counseling, knowledge, type 2 diabetes mellitus 
OPTIMIZATION AND QUERCETIN RELEASE TEST OF MORINGA LEAF EXTRACT (MORINGA OLEIFERA) IN GEL-MICROEMULSION PREPARATION Bhagawan, Weka Sidha; Atmaja, Ria Ramadhani Dwi; Atiqah, Sri Nur
Journal of Islamic Pharmacy Vol 2, No 2 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i2.4508

Abstract

Quercetin is a flavonoid compound of the flavonol group that has various biological activities for health. Moringa leaf is one of the plants rich in quercetin which is about 384.61 mg / 100 g. Quercetin is practically insoluble (4.5 μg / mL). To increase the solubility and release of quercetin microemulsion may be used as Drug Delivery Systems formulated with gels for transdermal use.The aim of this research is to obtain optimum combination formulation of surfactant (tween 80): cosurfactant (propylene glycol) to form optimal microemulsion system, to find out the characteristics of the preparation and to find out the rate of quercetin release of Moringa leaf extract (M. oliefera) in a gel-microemulsion preparation compared with a control gel (without microemulsion) using an HPMC (Hydroxypropyl methylcellulose) gel basis.The result shows that optimal concentration tween 80 comparison : propylene glycol to form optimal microemulsion system up to 30%: 20 % with VCO (virgin coconut oil) oil phase 5%. The characteristics observed including organoleptic, pH, viscosity, and stability are showing optimal condition. The average of quercetin content in gel-microemulsion preparation was 2,22 ± 0,077 ppm and on control gel was 2.37 ± 0.042 ppm. Quercetin release test using Franz diffusion cell using cellophane membrane, saline phosphate buffer pH 7,4 ± 0,05 and temperature 37 ± 0,5 °C for 6 hours. The average quercetin release flux in the gel-microemulsion preparation was 9.436 ± 1.178 (μg/cm 2/min1/2) and the control gel was 5,816 ± 0.485 (μg/cm2/min1/2).Based on these results it can concluded that the microemulsion gel preparation gives significant difference of quercetin flux rate compared with gel preparation. Keywords: Quercetin, Gel-Microemulsion, quercetin release, moringa leaf extract (Moringa oliefera)
Analisis Kriteria Sistem Jaminan Halal pada Produksi Susu di PT. Greenfields Indonesia Tahun 2019 Hartina, Siti; Syahrir, Achmad; Atmaja, Ria Ramadhani Dwi
Journal of Islamic Pharmacy Vol 4, No 2 (2019): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v4i2.8087

Abstract

World demand for halal pharmaceutical products, which include food, cosmetics, drugs, and other products will continue to grow with the increasing of global Moslems population in the world. Milk is one of the pharmaceutical products produced from livestock commodities. It is processed into 2 types of products namely ESL and UHT milk. In Indonesia, the halal status of a product is a crucial point for consumers who are predominantly by Moslems. In its processing, Indonesian Ulema Council (MUI) has a rule called HAS 23101, a halal certification requirement as an implementation of Halal Guarantee System. This study examines the importance of the Halal Assurance System criteria in milk production in the Indonesian food industry. The purpose of this study is to analyse the suitability of the halal guarantee system criteria for milk production in PT. Greenfields Indonesia based on HAS 23101 standards. This research is a descriptive observational study. The data collection process is carried out by providing a checklist to the halal management team in the food industry. The results obtained are the percentage of conformity to the 100% Halal Policy, 100% Halal Management Team, 100% Training and Education, 100% Material, 100% Product, 91.6% Product Facility, Written Procedure for Critical Activity 100%, 100% Search Capability, Products that do not meet 77.8% criteria, 100% internal audit, and 100% management review. The percentage of conformity results obtained as a whole was 97.2%.
Activity of 70% Ethanol Extract of Chrysophyllum cainito in Increasing Vertebrae Trabecular Bone Density in Female Mice Nur Imamah Utaminingtyas; Burhan Ma'arif; Dewi Sinta Megawati; Ria Ramadhani Dwi Atmaja
Majalah Obat Tradisional Vol 23, No 3 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.746 KB) | DOI: 10.22146/mot.37590

Abstract

Phytoestrogens are a class of compounds that have estrogen-like functions or structure. This research was conducted to find out the phytoestrogens activity in Chrysophyllum cainito leaves, in increasing the vertebrae trabecular bone density of female mice, using dexamethasone induction as osteoporosis model.  The 70% ethanol extract of C. cainito leaves was given to female mice with dose of 100; 200; and 400 mg/kgBW mice/day after being induced orally with dexamethasone with 0.145 mg/kgBW mice/day. The positive control used was 1.3 mg/kgBW mice/day alendronate. This research had been done in four weeks. The increasing of trabecular vertebrae bone density of female mice was measured with Histomorphometry staining methods. The result showed the 70% ethanol extract of C. cainito leaves have activity in increasing trabecular vertebrae bone density for female mice with optimum dose of 400 mg/kgBW mice/day. This activity occurs because phytoestrogens content in 70% ethanol extract of C. cainito leaves, that may replace the function of estrogen in its bond with ER.
The Effectiveness of Red Fruit Oil (Pandanus conideus Lamk.) Emulgel on the Acceleration of the Incision Wound Healing Process Fidia Rizkiah Inayatilah; Abdul Malik Guhir; Ria Ramadhani Dwi Atmaja
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.73135

Abstract

Incision wounds have a fairly high prevalence in Indonesia. Chemical treatment of incision wounds has adverse side effects, therefore alternative treatment with natural ingredients is needed, namely using red fruit oil as the basic ingredient. The purpose of this study is to determine the effectiveness of red fruit oil (Pandanus conoideus­­ Lamk.) gel emulsion on the healing process of incision wounds in males both macroscopically and microscopically. This is an experimental laboratory study. The study design used was true experimental with a post-test-only control group design approach. The population consisted of 25 male mice which were divided into 5 groups, namely: (1) K- was a control group where the incision wound on the back was given a gel emulsion base; (2) K+ was the control group where the incision wound on the back was given Iodine Povidone ; (3) P1 is the treatment group where the incision wound on the back is given a 5% red fruit oil gel emulsion (F1); (4) P2 is the treatment group where the incision wound on the back is given a red fruit oil gel emulsion 10% (F2); (5) P3 was the treatment group where the incision on the back was given a 15% red fruit oil gel emulsion (F3). The treatment was given for 14 days. The data were then analyzed using the ANOVA test. The result showed that the administration of red fruit oil emulgel had a significant effect on the size of the incision wound on the 7th day (p=0.035) and the 14th day (p=0.005). Giving red fruit oil emulgel also had a significant effect on the thickness of the epithelium (p=0.000) and the number of fibroblasts (p=0.000). It can be concluded that the administration of red fruit oil emulgel affects the healing process of the incision wound both macroscopically and microscopically.
Pengetahuan dan Perilaku Penggunaan Bawang Putih (Allium sativum) pada Masyarakat di Kelurahan Karang Agung Kalimantan Utara selama Pandemi Covid-19 Dina Puspa Melianti; Yen Yen Ari Indrawijaya; Ria Ramadhani Dwi Atmaja
Journal of Islamic Pharmacy Vol 7, No 1 (2022): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i1.14819

Abstract

Seluruh dunia saat ini sedang mengalami wabah corona virus yang merupakan penyakit pandemik disebabkan virus corona jenis baru yang menimbulkan masalah gangguan pernafasan akut hingga kematian. Keadaan menyebabkan kecemasan pada masayarakat kelurahan Karang Agung, Kec. Tanjung Palas Utara, Kab. Bulungan Kalimantan Utara sehingga masyarakat enggan memeriksakan diri ke rumah sakit saat mulai mengalami gejala. Adanya informasi bahwa bawang putih (Allium sativum) dapat mencegah Covid-19 menyebabkan masyarakat memilih untuk menangani sendiri dengan mengkomsumsinya. Beberapa penelitian menyatakan bahwa bawang putih (Allium sativum) belum terbukti secara invitro dapat menyembuhkan Covid-19, tetapi bawang putih memiliki manfaat sebagai antibiotik alami. Didalam bawang putih (Allium sativum)  terdapat senyawa organosulfur (Allin Allicin) serta flavonoid (quercetin) memiliki efek sebagai imunomodulator. Tujuan penelitian ini untuk mengetahui gambaran tingkat pengetahuan dan perilaku penggunaan bawang putih selama pandemi Covid-19. Jenis penelitian ini kuantitatif deskriptif. Pengambilan sampel menggunakan teknik cluster random sampling dengan rumus Slovin dengan hasil sampel minimal dari 1.010 populasi  pada margin error 5% sebesar 287. Hasil penelitian menunjukkan tingkat pengetahuan Covid sebagian besar dalam kriteria cukup dengan persentase sebesar 66% dan tingkat pengetahuan bawang putih sebagian besar dalam kriteria cukup dengan persentase sebesar 71%. Sedangkan Tingkat perilaku penggunaan sebagian besar dalam kriteria baik dengan persentase sebesar 53%.
AN ANALYSIS OF CONTRIBUTING FACTORS IN NURSES’ ACCURACY WHILE CONDUCTING TRIAGE IN EMERGENCY ROOM Ria Ramadhani Dwi Atmaja; Mohammad Hidayat; Mukhamad Fathoni
Journal of Nursing Science Update (JNSU) Vol. 8 No. 2 (2020)
Publisher : Department of Nursing, Faculty of Health Sciencce, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (283.266 KB) | DOI: 10.21776/ub.jik.2020.008.02.11

Abstract

Triage is aimed to arrange treatment priority to patients with different levels of urgency.These nurses who are responsible for triage must conduct standardized procedure. Hence,these nurse must acquire certain competency required to conduct triage. The competencyincludes basic knowledge, skills and attitude. Besides that, there are several contributingfactors playing significant role in triage procedure implementation, which is intrinsicfactors. Regarding to those factors, this study aimed to analyze those contributing factorsaffecting nurses’ accuracy in doing triage procedure in emergency room. This studyemployed correlational analytic design accompanied with cross sectional approach. Thepopulation in this study was all nurses who worked actively in the Emergency Room atRSUD in Malang Regency and Blitar City and thirty two respondents are taken as thesamples using population total method. The data is collected using observation sheetand questionnaire. The data analyzed through Partial Least Squares (PLS). It is showedthat knowledge level (p-value 0.000), skill level (p-value 0.000), attitude (p-value 0.000),intrinsic factors (p-value 0.000) are related to nurses’ accuracy in implementing triageprocedure. Therefore, based on those findings, the hospital’s management is suggested toimprove their nurses’ competency in implementing triage, especially by recommendingthem to participate in advanced emergency training and triage course.
Analisis Peresepan Polifarmasi Pada Pasien Geriatri dengan Diabetes Melitus Tipe 2 Berdasarkan Beers Criteria 2023 Alifia Putri Febriyanti; Ria Ramadhani Dwi Atmaja; Helma Chika Oktaviani; Dhani Wijaya
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.423

Abstract

Pertambahan penduduk lanjut usia menjadi perhatian dunia, dan mendapat perhatian khusus di Indonesia seiring dengan transisi menuju era "Aging Population". Salah satu masalah yang sering ditemukan pada lanjut usia adalah polifarmasi dan penggunaan obat berpotensi tidak tepat (PIMs). Polifarmasi dan penggunaan obat berpotensi tidak tepat pada lanjut usia menimbulkan berbagai efek yang tidak diinginkan, yang paling fatal adalah kematian. Penelitian ini bertujuan untuk mengidentifikasi obat berpotensi tidak tepat pada pasien geriatri penderita DM tipe 2 (DMT2) yang mendapat terapi polifarmasi di Puskesmas Sakra berdasarkan Beers Criteria 2023. Penelitian ini merupakan penelitian observasional dengan pendekatan retrospektif. Empat puluh pasien geriatri penderita DMT2, memenuhi kriteria inklusi dan eksklusi, ikut serta menjadi subyek penelitian. Hasil penelitian didapatkan mayoritas pasien memiliki rentang usia antara 55 hingga 65 tahun, berjenis kelamin perempuan, dan terdiagnosis hipertensi sebagai penyakit penyerta sebanyak 80%. Selain itu, sebagian besar pasien mengalami polifarmasi, yaitu menggunakan lebih dari lima jenis obat yang berbeda. Berdasarkan hasil penelitian, terdapat obat-obatan yang dikonsumsi geriatric termasuk dalam kriteria 1 yaitu obat golongan sulfonilurea sebanyak 11,7%, golongan NSAID sebanyak 6,4%, dan golongan H1 sebanyak 1,5%. Simpulan dari penelitian ini adalah seluruh resep pasien geriatri dengan DMT2 di Pusksmas Sakra mendapatkan terapi polifarmasi dan obat yang yang tidak tepat berdasarkan Beers Criteria 2023.
Efek Neuroprotektif Fraksi Air Daun Semanggi (Marsilea crenata Presl.) secara In Vitro Burhan Ma'arif; Muslim, Menara; Riyanti, Anisa Eka; Guhir, Abdul Malik; Amalia, Dilla; Saidah, Nisfatul Lailatus; Anggraini, Wirda; Atmaja, Ria Ramadhani Dwi; Laswati, Hening; Agil, Mangestuti
FARMASIS: Jurnal Sains Farmasi Vol 2 No 1 (2021): Farmasis : Jurnal Sains Farmasi
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v2i1.3537

Abstract

Background: Estrogen deficiency can trigger several diseases, one of which is neurodegenerative. Neurodegenerative begins with neuroinflammation, which triggers the activation of microglia cells resulting in a pro-inflammatory activity. Potential and relatively safe therapy to use to overcome it is by using phytoestrogen compounds. Marsilea crenata Presl. is a plant that contains phytoestrogens. Objective: The purpose of this study was to analyze the neuroprotective effect of the water fraction of Marsilea crenata Presl. leaves which was shown by inhibition of neuroinflammation and marked by increased levels of MHC II against HMC3 microglia cells. Methods: IFN-γ is induced into HMC3 microglia cells for 24 hours to cause inflammatory conditions. Marsilea crenata Presl. leaves water fraction was given at a dose of 62,5; 125; and 250 µg / ml. Analysis of the neuroprotective effect of HMC3 microglia cells using the ICC method with the aid of the CLSM instrument. Results: The results of this study indicate that the water fraction of Marsilea crenata Presl. leaves can reduce MHC II expression at concentrations of 125 and 250 μg / ml with values ​​of 465,748 and 460,884 AU at p less than 0,005. Conclusion: This study concludes that the water fraction of Marsilea crenata Presl. has neuroprotective activity shown at doses of 125 and 250 μg/ml which can reduce MHC II expression in HMC3 microglia cells induced by IFN-γ. The ED50 value which has a neuroprotective effect is at a dose of 0,582 μg/ml.  
Co-Authors Abdul Hakim Abdul Malik Guhir Alifia Putri Febriyanti Amalia, Dilla Atiqah, Sri Nur Burhan Ma'arif Burhan Ma'arif Dhani Wijaya Dhani Wijaya, Dhani Dina Puspa Melianti Faizah, Nadia Nur Fathia Faza Rahmadanita Fidia Rizkiah Inayatilah Guhir, Abdul Malik Habibah, Atiqoh Nur Hartina, Siti Helma Chika Oktaviani Hening Laswati Putra Mangestuti Agil Mohammad Hidayat Mufidah, Fahda Dina Mukhamad Fathoni Muslim, Menara Nafisah, Fika Sayyidatun Nur Imamah Utaminingtyas Nurwijayanti Riyanti, Anisa Eka Roihatul Mutiah Sadli Syarifuddin Saidah, Nisfatul Lailatus Syahrir, Achmad Weka Sidha Bhagawan Wirda Anggraini Yen Yen Ari Indrawijaya