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All Journal International Journal of Public Health Science (IJPHS) Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Sains dan Komunitas Jurnal EduHealth

Endang Darmawan

Ahmad Dahlan University

Author-ID : 2386063

Health Professions Medicine & Pharmacology Public Health Veterinary

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Articles

COST AND EFFECTIVENESS OF ATYPICAL-ATYPICAL ANTIPSYCHOTIC COMBINATIONS AND ATYPICAL-TYPICAL ANTIPSYCHOTIC COMBINATIONS IN PATIENTS OF PSYCHOTIC DISORDERS IN INSTALLATION OF EMERGENCY IN GRHASIA MENTAL HOSPITAL, YOGYAKARTA Arya Dibyo Adisaputra; Endang Darmawan; Arum Siwinarni
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Psychotic disorders create a burden on the government, family, and society because of decreasing patient productivity. The use of atypical-atypical and atypical-typical antipsychotic combinations is one of the most commonly used combinations for patients with psychotic disorders. The study was conducted to determine the average total cost and effectiveness of the therapy measured by the difference in PANSS-EC pre-post scores during intensive care. The study was conducted prospectively to analyse the total cost and effectiveness of the therapy using combinations of antipsychotics in psychotic disorders patients. The measured costs include the cost of nursing classes, laboratory, medical treatment, doctor's visit, and antipsychotic. The effectiveness is measured by the difference in PANSS-EC pre-post scores. As many as 32 treated patients with psychotic disorders met the inclusion criteria. The average cost of atypical-typical antipsychotic combination group (Rp1,184,043) was higher than atypical atypical antipsychotic combination group (Rp1,115,829). The effectiveness of the therapy was represented by the value of the difference between the PANSS-EC pre and post scores, which in this research yielded a mean of 7,125 for atypical-atypical antipsychotic combinations and 8,375 for atypical-typical antipsychotic combinations. In conclusion, there is a difference in the total average cost and effectiveness of the therapy. There is a difference between PANSS-EC pre and post scores during the time period from intensive room to quiet room in atypical-typical antipsychotic combinations compared with atypical-atypical antipsychotic combinations.

THE SUB-CHRONIC TOXICITY TEST OF MENIRAN (Phyllanthus niruri L.) AND PEGAGAN (Centella asiatica) EXTRACT IN WISTAR STRAIN RATS ON LIVER AND KIDNEY FUNCTION Endang Darmawan; Iin Narwanti; Siti Fatmawati Fatimah; Ira Aprilia Wulandari; Ria Putri Salma; Dzulhaifa Dzulhaifa
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Meniran (Phyllantus niruri L.) and Pegagan (Centella asiatica L.) was proven had activity that considered as an antioxidant. However, the safety was not confirmed. This research is intended to evaluate sub-chronic toxicity of standardized combination extract of meniran and pegagan on liver and kidney function. This research used post-test-control design. Twenty female and twenty male Wistar strain rats divided into 4 groups. The first group was controlled in dosage of CMC Na 0.5%. The others were given a combination of meniran and pegagan extract in ratio with different dosage (50:50; 250:250; and 1250:1250 mg/KgBW). Sub-chronic toxicity test of meniran and pegagan combination was given orally once a day for 28 consecutive days. On the 29th day, all the rats were sacrificed and blood samples were analyzed using automatic analyzer. SGOT, SGPT, BUN, and creatinine value were statistically analyzed using one way ANOVA with post hoc LSD (p0.05). The results show that treatment of meniran and gotu kola combination had no significantly different of SGOT and creatinine value of male and female rats, and SGPT value of male rats (p0.05). The treatment of meniran and gotu kola combination had significantly different of BUN value of male and female rats, and SGPT value of female rats (p0.05) but still within normal range. Based on this study, it can be concluded that orally administered of meniran and gotu kola extract combination at doses 50:50 mg/KgBW; 250:250 mg/KgBW; and 1250:1250 mg/KgBW had no affected on SGOT, SGPT, BUN and creatinine value of Wistar strain rats on sub-chronic administration for 28 consecutive days.

Black Cumin Seed Oilas Hepatoprotector in Decreasing SGPT and SGOT Activity and Increasing p53 Gene Expression in Sprague Dawley Rats Induced by Alloxan Akrom Akrom; Endang Darmawan; Liesma Yuhelvia
International Journal of Public Health Science (IJPHS) Vol 4, No 3: September 2015
Publisher : Intelektual Pustaka Media Utama

The objective of this research was to determine the effect of BCSO on SGPT/SGOT levels and p53 expression in rats induced by alloxan. This study applied a post test only control group design. A total of 42 SD rats were divided into 6 groups. Group I was normal rats. Group II (negative control) was given alloxan. Group III and IV (treatment groups) were given BCSO with equivalent doses of 6.8 mg/kg and 68 mg/kg thymoquinone, respectively (BCSO 6.8 and BCSO68 groups). Group V (positive control) was given vitamin C. Group VI (control media) were given DMSO. BCSO and Vitamin C are given for 1 week. Alloxan was given on 7th day, i.p. On the 8th day did blood sampling for measurement of SGPT and SGOT levels. Liver retrieval was performed on the 9th day continued immunohistochemistry staining. The average levels of SGPT/SGOT were then analyzed with ANOVA test. p53 expression was analyzed by Kolmogorov Semirnov and Levene then followed by Kruskal Wallis and Mann-Whitney. Statistical tests performed on 95% confidence level. The results showed that the induction of alloxan increased levels of SGPT/SGOT. BCSO68 reduced SGPT /SGOT levels in alloxan-induced rats (p < 0.05). Both BCSO 6.8 and BCSO68 increased the expression of p53 in liver tissue of alloxan – induced rats. Average percentage of p53 expression in group I to group VI were 11.12 ± 0.37; 19.24 ± 4.47; 30.31 ± 1.59; 40.43 ± 1.74; 29.67 ± 0.47; 12.02 ± 1.01, respectively. The result of statistical analysis showed the value of p < 0.05 in all groups except in group III. It can be concluded that BCSO may have hepatoprotective effect and increase the expression of p53 in the liver of alloxan-induced rats.

PENGARUH PEMAKAIAN KOMBINASI MINYAK JINTEN HITAM (Nigella sativa) dan MADU (Apis mellifera) SEBAGAI ANTI-ACNE SECARA TOPIKAL PADA SUKARELAWAN WANITA Baiq Lenysia Puspita Anjani; Ari Sabar Hati; Halimah Az-Zahra; Fitri Rahmawanti; Endang Darmawan
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Acne mostly affects teenagers with prevalence of 85%. Changing habits of cosmetics may affect the incidence of acne vulgaris. Healing acne can use herbal ingredients such as black cumin oil and honey. Black cumin oil effective for treating mild acne vulgaris and moderate acne vulgaris. Honey has property that can kill the bacteria Propionibacterium acnes. Â The purpose of this study is to determine the anti-acne activity in use of black cumin oil and honey combination in 1:1 ratio for 14 days in women. This study included experimental study with pre-post treatment study design. There are 2 groups, control group (six women volunteer) and treatment group (six women volunteer). For 14 days, control group use chemical drugs anti-acne, while treatment group use black cumin oil and honey combination in 1:1 ratio. Analysis of data used independent sample t-test with confidence interval 95%. The results show that treatment group of women who use black cumin oil and honey combination in 1:1 ratio for 14 days compared with the control group of women there is no difference in reducing the number of parameters black blackheads, white blackheads, papules, pustules, hyperpigmentation, erythema, pruritis, xerosis, desquamation, and sunburn with a value of p> 0.05. The conclusion of this study is the use black cumin oil and honey combination in 1:1 ratio for 14 days has effect as Â anti-acne in women, but statistically not significant.Â

Satisfaction Relationship Of Outpatient Clinic Towards The Pharmacy Installation's Services With Interest To Re-Purchace Prescription Drugs In Pharmacy Installation Of General Hospital Dr. Soedirman Kebumen Anwar Sodik; Eka Wuri Handayani; Endang Darmawan; Muji Pramono
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

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Competition in the hospital business makes patient satisfaction the priority. Customer satisfaction. Therefore, the hospital needs to assess what factors will affect patient satisfaction and whether patient satisfaction is met to maintain the patient. This study is descriptive and analytical with a quantitative approach, this study design was a cross-sectional survey. Data was collected through questionnaires to 370 respondents in the pharmacy installation of General Hospital dr. Soedirman Kebumen. Data analysis was performed by bivariate analysis using chi-square with SPSS 15.0 programs. Based on the five dimensions of service satisfaction, the smaller the P value, the more influential it is in increasing or decreasing the interest in re-purchase drug prescriptions at Dr. Soedirman Hospital, Kebumen. From this study, the smallest P value is the tangible dimension, namely 0.001, followed by the reliability dimension of 0.009. This shows that the most important role in increasing interest in re-purchase prescription drugs are the facilities and infrastructure, as well as the waiting time for pharmaceutical services

Co-Authors Adisaputra, Arya Dibyo Akrom, Akrom Anwar Sodik Ari Sabar Hati Arum Siwinarni Baiq Lenysia Puspita Anjani Dzulhaifa Dzulhaifa Eka Wuri Handayani Fitri Rahmawanti Halimah Az-Zahra Iin Narwanti Ira Aprilia Wulandari Liesma Yuhelvia Muji Pramono Ria Putri Salma Siti Fatmawati Fatimah, Siti Fatmawati

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