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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Pharmascience Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Buana Farma Jurnal Pengabdian Masyarakat Aufa (JPMA) Herbal Medicine Journal Jurnal Pengabdian Farmasi dan Sains
Adisaputra, Arya Dibyo
Pharmacy Study Program, Mathematics And Natural Sciences Faculty, Universitas Tadulako
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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COST AND EFFECTIVENESS OF ATYPICAL-ATYPICAL ANTIPSYCHOTIC COMBINATIONS AND ATYPICAL-TYPICAL ANTIPSYCHOTIC COMBINATIONS IN PATIENTS OF PSYCHOTIC DISORDERS IN INSTALLATION OF EMERGENCY IN GRHASIA MENTAL HOSPITAL, YOGYAKARTA Arya Dibyo Adisaputra; Endang Darmawan; Arum Siwinarni
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.188 KB) | DOI: 10.24071/jpsc.002453

Abstract

Psychotic disorders create a burden on the government, family, and society because of decreasing patient productivity. The use of atypical-atypical and atypical-typical antipsychotic combinations is one of the most commonly used combinations for patients with psychotic disorders. The study was conducted to determine the average total cost and effectiveness of the therapy measured by the difference in PANSS-EC pre-post scores during intensive care. The study was conducted prospectively to analyse the total cost and effectiveness of the therapy using combinations of antipsychotics in psychotic disorders patients. The measured costs include the cost of nursing classes, laboratory, medical treatment, doctor's visit, and antipsychotic. The effectiveness is measured by the difference in PANSS-EC pre-post scores. As many as 32 treated patients with psychotic disorders met the inclusion criteria. The average cost of atypical-typical antipsychotic combination group (Rp1,184,043) was higher than atypical atypical antipsychotic combination group (Rp1,115,829). The effectiveness of the therapy was represented by the value of the difference between the PANSS-EC pre and post scores, which in this research yielded a mean of 7,125 for atypical-atypical antipsychotic combinations and 8,375 for atypical-typical antipsychotic combinations. In conclusion, there is a difference in the total average cost and effectiveness of the therapy. There is a difference between PANSS-EC pre and post scores during the time period from intensive room to quiet room in atypical-typical antipsychotic combinations compared with atypical-atypical antipsychotic combinations.
Cost Effectiveness Analysis Antibiotik Profilaksis pada Pasien Apendisitis di RSUD Anutapura Palu Tahun 2018 Khusnul Diana; Muzna Muzna; Muhamad Rinaldhi Tandah; Arya Dibyo Adisaputra
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11005

Abstract

Apendisitis adalah peradangan akibat infeksi pada apendiks yang mana memerlukan penanganan berupa pembedahan untuk mencegah komplikasi perlu dilakukannya apendiktomi atau pengangkatan apendiks. Apendiktomi merupakan operasi bersih kontaminasi dan termasuk dalam kategori tinggi untuk diberikan antibiotik profilaksis. Tujuan penelitian ini adalah untuk mengetahui manakah penggunaan antibiotik profilaksis yang paling cost-effective pada pasien apendisitis di RSUD Anutapura Palu. Jenis penelitian ini adalah penelitian deskriptif dengan pengambilan data secara retrospektif. Penelitian ini dilakukan untuk menganalisis efektivitas biaya (Cost-Effectiveness Analysis) antibiotik profilaksis pada pasien apendisitis dengan melihat parameter penurunan suhu tubuh. Subyek penelitian yaitu 69 pasien rawat inap yang memenuhi kriteria inklusi dan eksklusi. Hasil penelitian menunjukan terdapat pasien yang menggunakan terapi antibiotik tunggal sebanyak 35 pasien (50,72%), kombinasi 2 antibiotik 27 pasien (39,13%) dan kombinasi 3 antibiotik 7 pasien (10,14%). Rata-rata total biaya medis langsung penggunaan antibiotik tunggal Rp. 7.430.971, kombinasi 2 antibiotik Rp. 11.236.020, kombinasi 3 antibiotik Rp. 12.321.345. Berdasarkan perhitungan ACER, diperoleh antibiotik yang memiliki  biaya rendah adalah antibiotik tunggal seftriakson dengan nilai Rp. 159.199/unit suhu. Kata Kunci: Apendisitis, Antibiotik Profilaksis, Apendiktomi, Cost-Efffectiveness Analysis, Direct Medical Cost Appendicitis is inflammation due to infection of the appendix which requires treatment in the form of surgery to prevent complications, it is necessary to do an appendectomy or removal of the appendix. Appendectomy is a clean operation of contamination and is included in the high category for prophylactic antibiotics. The purpose of this study was to determine which use of prophylactic antibiotics was the most cost-effective in appendicitis patients at Anutapura Hospital Palu. This type of research is descriptive research with retrospective data collection. This study was conducted to analyze the cost-effectiveness (Cost-Effectiveness Analysis) of prophylactic antibiotics in appendicitis patients by looking at the parameters of decreasing body temperature. The research subjects were 69 hospitalized patients who met the inclusion and exclusion criteria. The results showed that there were 35 patients (50.72%), a combination of 2 antibiotics (39.13%) and a combination of 3 antibiotics 7 patients (10.14%). The average total direct medical cost of using a single antibiotic is Rp. 7,430,971, a combination of 2 antibiotics Rp. 11,236,020, a combination of 3 antibiotics Rp. 12,321,345. Based on ACER calculations, the antibiotic that has a low cost is the single antibiotic ceftriaxone with a value of Rp. 159,199 /unit temperature.
Drug Plan and Control (Drug PC): Web-Based System Information of Drug and Inventory Control Diana, Khusnul; Adisaputra, Arya Dibyo; Tandah, Muhamad Rinaldhi
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52618

Abstract

Pengelolaan obat di sarana kefarmasian merupakan kegiatan yang penting di perhatikan karena berhubungan dengan keberlangsungan sarana serta kepuasan pengguna obat. Penggunaan sistem informasi dalam mengelola obat dapat mempermudah pekerjaan serta menjadikan hal tersebut efektif dan efisien. Terutama dalam kegiatan perencanaan dan pengendalian persediaan farmasi. Tujuan penelitian ini adalah membangun sistem informasi dalam perencanaan jumlah obat dan mengendalikan persediaan farmasi di sarana kefarmasian dengan metode EOQ dan ROP. Pembangunan sistem informasi ini menggunakan bahasa pemprograman PHP dan untuk databasenya menggunakan MySQL. Metode yang digunakan dalam aplikasi ini adalah metode waterfall. Kesesuaian hasil perhitungan nilai perencanaan, EOQ dan ROP dibandingkan dengan menggunakan perhitungan melalui excel. Pengujian fungsionalitas aplikasi dilakukan dengan menggunakan blackbox testing kepada beberapa responden. Sistem informasi berbasis web yang telah dibangun memiliki empat menu utama yaitu data obat, stok obat, ramalan perencanaan obat dengan metode konsumsi, pengendalian persediaan dengan metode EOQ ROP. Nilai jumlah perencanan obat, EOQ dan ROP menunjukkan hasil yang sesuai dengan dibandingkan perhitungan menggunakan excel. Sistem informasi berbasis web dapat digunakan dengan baik dan memberikan hasil yang sesuai seperti perhitungan secara manual dan excel.
Identifikasi Potentially Inappropriate Medication (PIM) Berdasarkan Beers Criteria Pada Pasien Covid-19 di RSUD Undata Provinsi Sulawesi Tengah Adisaputra, Arya Dibyo; Rumi, Amelia; Tahir, Muhammad Tamrin; Zainal, Setiawati Fadhilah; Sulistiana, Sri; Andriani, Lilik
Indonesian Journal of Clinical Pharmacy Vol 11, No 4 (2022)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2022.11.4.331

Abstract

Potentially Inappropriate Medication (PIM) atau lebih dikenal dengan penggunaan terapi obat yang berpotensi tidak tepat ialah pengobatan berkaitan dengan risiko efek samping obat. Penelitian ini berfokus pada jumlah penggunaan terapi obat yang berpotensi tidak tepat terhadap pasien lansia (geriatri) yang terkonfirmasi positif Covid-19. Tujuan penelitian ini adalah untuk mengidentifikasi seberapa besar angka kejadian Potentially Inappropriate Medication (PIM) berdasarkan Beers Criteria 2019 pada pasien geriatri di RSUD Undata Provinsi Sulawesi Tengah. Pengambilan data dilakukan di ruangan rekam medik RSUD Undata Provinsi Sulawesi Tengah selama bulan Maret-April 2022. Metode yang digunakan adalah metode deskriptif yang bersifat retrospektif dengan mengambil data rekam medik pasien sebanyak 93 rekam medik secara simple random sampling. Data kemudian dianalasis secara deskriptif dengan menggunakan data yang diperoleh dari catatan rekam medik meliputi karakteristik demografi, profil penggunaan obat selama proses pengobatan, dan Beers Criteria. Hasil penelitian menunjukkan bahwa dari 93 sampel rekam medik yang diambil, terdapat 89 pasien yang teridentifikasi PIM dengan 203 angka kejadian PIM yang masuk ke dalam kategori Beers Criteria. Kategori 1 terdapat 166 kejadian (81,77%), kategori 2 terdapat 3 kejadian (1,48%), kategori 3 terdapat 16 kejadian (7,88%), kategori 4 terdapat 15 kejadian (7,39%), dan kategori 5 terdapat 3 kejadian (1,48%). Hal ini menunjukkan bahwa angka kejadian PIM berdasarkan Beers Criteria 2019 pada pasien geriatri yang terkonfirmasi Covid-19 di RSUD Undata Provinsi Sulawesi Tengah masih sangat tinggi.
Evaluasi Kadar Glukosa Darah Pada Pasien Hipertensi yang Menggunakan Obat Golongan Angiostensin Receptor Bloker (ARB) di Rumah Sakit Umum Daerah Undata Palu Susilawati, Ni Made; Fresha, Winda; Rumi, Amelia; Adisaputra, Arya Dibyo
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.151

Abstract

Hipertensi adalah kondisi medis yang ditandai dengan peningkatan tekanan darah arteri secara berkelanjutan. Salah satu golongan obat lini pertama pengobatan hipertensi adalah golongan Angiotensin Receptor Blocker (ARB). Obat ini berpotensi dapat dapat mempengaruhi metabolisme glukosa darah. Penelitian ini bertujuan untuk mengevaluasi kadar glukosa darah pada pasien hipertensi yang menjalani terapi menggunakan obat ARB, seperti losartan, candesartan, valsartan, dan telmisartan, di RSUD Undata Palu. Penelitian ini dilakukan dengan metode cross-sectional secara prospektif, melibatkan 30 pasien yang memenuhi kriteria inklusi. Pasien yang diteliti berusia ≥18 tahun, telah menjalani terapi ARB selama 3 bulan, memiliki hipertensi tanpa diabetes melitus, dan tidak menggunakan obat lain yang memengaruhi kadar glukosa darah. Pengukuran dilakukan menggunakan glucometer Accu-Chek Performa. Hasilnya menunjukkan penurunan kadar glukosa darah puasa dari rata-rata 113.83 mg/dl menjadi 107.83 mg/dl, dengan selisih 6.367 mg/dl. Uji statistik menunjukkan p=0.049 (p<0.05), yang mengindikasikan bahwa ARB dapat menurunkan kadar glukosa darah pada pasien hipertensi.
EFEK PENGGUNAAN BETA BLOCKER TERHADAP KEJADIAN HIPOGLIKEMIA PADA LANSIA: NARRATIVE REVIEW Adisaputra, Arya Dibyo; Susilawati, Ni Made; Fatkhiya, Musa Fitri; Gibran, Nabial Chiekal; Futihat, Chilyati Eky
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1501

Abstract

Elderly patients are considered a vulnerable population, as advanced age may exacerbate existing conditions or predispose individuals to adverse effects such as hypoglycemia. While hypoglycemia most frequently occurs in patients with diabetes who are treated with insulin or oral hypoglycemic agents, it may also develop in non-diabetic individuals under certain circumstances. The use of beta-blockers has been identified as one potential contributing factor to hypoglycemic events. This article aims to review the adverse effects of beta-blocker therapy in relation to hypoglycemia among older adults. A narrative review was conducted through electronic databases including PubMed, Google Scholar, and ScienceDirect. The inclusion criteria were studies published within the last 10 years involving older patients who experienced hypoglycemia while receiving beta-blocker therapy. The search yielded 38 articles, of which only 4 met the inclusion criteria. In conclusion, the use of β-blockers appears to be associated with an increased risk of severe hypoglycemia; however, evidence specifically addressing the geriatric population remains limited.
Correlation of Blood Glucose, Creatinine, and Uric Acid with Blood Pressure in Hypertension Patients : Korelasi Glukosa Darah, Kreatinin, dan Asam Urat dengan Tekanan Darah Pada Pasien Hipertensi Faustine, Ingrid; Yuliet, Yuliet; Hardani, Ririen; Hamdani, Silviana; Alfia, Dhara; Susilawati, Ni Made; Adisaputra, Arya Dibyo
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 11 No. 1 (2025): (March 2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2025.v11.i1.17638

Abstract

Poorly controlled hypertension in hypertensive patients can increase the risk of cardiovascular disease in the future. Some of the triggering factors are impaired kidney function which is characterized by an increase in creatinine levels and other factors as well, namely an increase in uric acid levels and an increase in blood sugar levels. This study aims to analyze the correlation between blood glucose, creatinine, and uric acid levels in hypertensive patients in Central Sulawesi. With a cross-sectional design, this observational study involved 50 adult hypertensive patients in health facilities. Data were taken from laboratory examination results during visits and analyzed descriptively and analytically. The results showed that 60% of hypertensive patients were female, 62% had a family history of hypertension, and 80% still had blood pressure that was included in the criteria for hypertension. As many as 34% of hypertensive patients had abnormal blood glucose levels, 32% had abnormal creatinine levels, and 26% had abnormal uric acid levels. Still, no relationship was found between the three with blood pressure (p> 0.05). The correlation between blood glucose and blood pressure was -0.221, creatinine and blood pressure was -0.112, and uric acid and blood pressure was 0.132. It can be concluded that there is a positive correlation with a very weak correlation strength between uric acid levels and blood pressure in hypertensive patients.
Pelatihan Pengelolaan dan Pemusnahan Limbah Obat Rusak dan Kadaluarsa di Desa Kotapulu Kabupaten Sigi Tandah, Muhamad Rinaldhi; Diana, Khusnul; Adisaputra, Arya Dibyo; Hardani, Ririen
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 2 No. 2 (2024): April 2024
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2024.v2.i2.17096

Abstract

The widespread circulation of illegal drugs poses a serious threat to society as it can have negative impacts on health. In 2019, BPOM Palu confiscated illegal drugs and cosmetics from various areas in Central Sulawesi. A law enforcement operation in Sigi Regency on September 23, 2020, together with the Central Sulawesi Regional Police, successfully seized Class G prescription drugs, traditional medicines, and illegal cosmetics (BPOM Palu, 2022). The main cause of illegal drug circulation is the improper reuse of household drug waste, exploited by irresponsible parties. The use of illegal drugs, which may consist of counterfeit, damaged, or expired items, can endanger health and even lives. One crucial step to prevent this is by managing drug waste properly. Since 2019, BPOM has been conducting awareness campaigns such as "Beware of Illegal Drugs, Dispose of Drug Waste Properly" to educate the public on proper drug disposal (BPOM, 2019). Many people still don't understand the correct way to manage and dispose of expired drugs. Most of them throw these drugs into the trash, potentially fueling illegal drug reuse by irresponsible parties. Training and awareness efforts, such as those conducted in Kotapulu Village, Dolo District, Sigi Regency, are highly relevant. With better knowledge of proper drug management and disposal, it is hoped that communities can independently address drug waste issues, ultimately reducing the circulation of illegal drugs in the region. These activities are crucial for educating the public about the dangers of illegal drugs and the importance of proper drug waste management. The goal is to help reduce the circulation of illegal drugs, especially in Central Sulawesi, thereby safeguarding the overall health and safety of the community.
Edukasi Dan Skrining Kesehatan Penyakit Degeneratif Pada Masyarakat Desa Tosale, Kabupaten Donggala Adisaputra, Arya Dibyo
Jurnal Pengabdian Masyarakat Aufa (JPMA) Vol. 4 No. 3 (2022): Vol. 4 No. 3 Desember 2022
Publisher : Universitas Aufa Royhan Di Kota Padangsidipuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51933/jpma.v4i3.879

Abstract

Penyakit Tidak Menular (PTM) sebagian besar merupakan penyakit degeneratif yang berkait dengan proses penuaan. Penyakit degeneratif merupakan kondisi kesehatan dimana organ atau jaringan terkait keadaan yang terus menurun seiring waktu. Tujuan pelaksanaan penyuluhan dan pemeriksaan kesehatan gratis yang dilakukan untuk masyarakat Desa Tosale, Kabupaten Donggala adalah meningkatkan kesehatan masyarakat melalui pemeriksaan kesehatan berupa cek tekanan darah, gula darah, kolestero total dan asam urat, meningkatkan pengetahuan serta memberikan motivasi kepada masyarakat terkait pentingnya kesadaran untuk melakukan pemeriksaan secara rutin. Metode yang digunakan yaitu melakukan pemeriksaan kesehatan dengan menggunakan alat pengukur tekanan darah, dan meggunakan alat digital yang terhubung dengan menggunakan strip untuk mengukur kadar gula darah, kolesterol dan asam urat. Jumlah peserta yang hadir saat pemeriksaan berjumlah 50 masyarakat dengan rentang umur 20-70 tahun. Setelah dilakukan pemeriksaan diperoleh sebanyak 23 orang (46%) mengalami hipertensi dan peningkatan kolesterol, pada pemeriksaan gula darah sebanyak 7 orang (14%) yang mengalami peningkatan dari normal, selanjutnya sebanyak 9 orang (18%) yang mengalami peningkatan kadar asam urat, sementara 11 orang (22%) dalam kondisi normal.
Co-Authors Alfia, Dhara amelia rumi, amelia Andriani, Lilik Arum Siwinarni Endang Darmawan Fatkhiya, Musa Fitri Fresha, Winda Futihat, Chilyati Eky Gibran, Nabial Chiekal Hamdani, Silviana Ingrid Faustine Khusnul Diana Muhamad Rinaldhi Tandah Muzna Muzna Ni Made Susilawati Ririen Hardani Setiawati Fadhilah Zainal Sri Sulistiana Tahir, Muhammad Tamrin Yuliet Yuliet