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All Journal Majalah Patologi Indonesia KREATIF: Jurnal Pengabdian Masyarakat Nusantara Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran
Welly Hartono Ruslim
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Dentistry Health Professions Public Health Social Sciences

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Hubungan Imunoekspresi β-Catenin antara Karsinoma Sel Skuamosa Oral Derajat Rendah dan Derajat Tinggi Berdasarkan Sistem Grading Bryne. Welly Hartono Ruslim; Ening Krisnuhoni; Kusmardi Suid
Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (700.72 KB)

Abstract

Background β-catenin is an important protein in cellular adhesion and signal transduction. In unstimulated condition, β-catenin only appears on the cellular membrane. Altered expression of β-catenin has been associated with progressiveness and metastatic process of malignancy in human. The aim of this study was to evaluate the expression of β-catenin on oral squamous cell carcinoma (OSCC) and also to assess its different expression in low grade and high grade lesions based on Bryne grading system. Methods This study was conducted on 2 groups of OSCC which included 20 cases of low grade and 20 cases of high grade. Immunohistochemistry staining of β-catenin was used to identify the difference of its expression in cell membrane, cytoplasm, and nuclei on invasive tumor front. Results The expression of β-catenin on cell membrane, cytoplasm, and nuclei showed significant difference between low and high grade OSCC (p=0.000; p=0.005; and p=0.035, respectively). There has not been any significant association between β-catenin expression with age, sex, and tumor location. Conclusion Expression of β-catenin could showed morphological change the OSCC. Key words : β-catenin, Bryne grading, oral squamous cell carcinoma (OSCC).
Kegiatan Pengabdian Masyarakat Dengan Penilaian Rasio Apolipoprotein A Dan B Dalam Memantau Risiko Penyakit Jantung Pada Lansia Welly Hartono Ruslim; Raden Seliwat Agung Aditya; Chandy Linardi Putra
KREATIF: Jurnal Pengabdian Masyarakat Nusantara Vol. 4 No. 2 (2024): Juni : Jurnal Pengabdian Masyarakat Nusantara
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/kreatif.v4i2.3390

Abstract

Coronary heart disease is a serious medical condition characterized by narrowing or blockage of the coronary arteries, leading to decreased blood flow to the heart and a high risk of causing chest pain, shortness of breath, fatigue and heart attack. In the elderly, coronary heart disease can worsen the quality of life and increase morbidity and mortality rates. The importance of health education and screening for apolipoprotein A (ApoA) and B (ApoB) in the elderly is crucial because the ApoA/ApoB ratio is an important indicator in monitoring the risk of heart disease. This community service activity aims to screen the ApoA/ApoB ratio as an indicator in monitoring the risk of heart disease in the elderly. With the PDCA (Plan-Do-Check-Act) approach, outreach, blood sampling, health education and evaluation of results are carried out to provide specific health recommendations. Screening results showed variations in the distribution of the ApoA/ApoB ratio between genders, emphasizing the importance of routine monitoring and healthy lifestyle interventions to prevent heart disease and improve the quality of life of the elderly.
Gambaran Diferensiasi dan Stadium Karsinoma Kolorektal Welly Hartono Ruslim; Edwin Destra; William Gilbert Satyanegara; Yohanes Firmansyah
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 1 No. 3 (2023): Juli : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v1i3.2104

Abstract

Introduction: The third most common type of cancer and the second biggest killer of both men and women is colorectal cancer. Asia and Indonesia are two regions where this carcinoma is an issue. Purpose: To known distribution of gender, primary cancers site, differentiation status, and staging profile of colorectal carcinoma.Method: This research use descriptive observational methods. The Medical Record Tabulation Data of the Faculty of Medicine, UNTAR, from 2020 to 2023 provided the data for this study. Patients with colorectal carcinoma who underwent a routine histological examination met the inclusion criteria for this study. Gender, primary cancer site, differentiation status, and cancer staging profile (TNM classification) were the characteristics evaluated in this study. The statistical method utilized in this study was descriptive analysis. Result: The results of the study revealed that the average age of occurrence of colorectal carcinoma was 58.06 (13.08) years, dominated by male sex in 30 (58.8%) respondents, the most primary location was in the colon at 26 (52.0%) ) respondents, with generally good differentiation in 39 (76.5%) respondents. Conclusion: Colorectal carcinoma most often occurs in the colon and is generally well differentiated.
Co-Authors Chandy Linardi Putra Edwin Destra Ening Krisnuhoni Kusmardi Suid Raden Seliwat Agung Aditya William Gilbert Satyanegara Yohanes Firmansyah