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All Journal ODONTO Dental Journal Interdental Jurnal Kedokteran Gigi (IJKG) Odonto dental journal
Boy Muchlis Bachtiar
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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The Role of IL-6 and IGF-1 in Periodontitis Bone Destruction Ikrima, Abidah; Gunawan, Erwin; Rohmah, Devi Kartika; Bachtiar, Boy Muchlis; Bachtiar, Endang Winiati
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.127-135

Abstract

Periodontitis is an inflammatory condition affecting the tissues supporting the teeth, destroying the periodontal ligament and alveolar bone. This condition is initiated by periodontal pathogens, which trigger an immune response resulting in tissue damage. Pro-inflammatory cytokines, particularly IL-6, have an important role in this process. IL-6, produced by various cells, including immune and periodontal ligament cells, enhances osteoclastogenesis by enhancing RANKL expression, thereby promoting bone resorption. Conversely, IGF-1, a hormone like insulin, is critical in bone homeostasis and regeneration. IGF-1, synthesised in the liver and locally in tissues, aids in the proliferation and differentiation of osteoblasts and osteoclasts, facilitating bone remodelling. IGF-1 also interacts with IL-6 to modulate inflammatory responses and osteoclast activity. Understanding the interplay between IL-6 and IGF-1 offers insights into the mechanism of bone resorption in periodontitis and identifies potential therapeutic targets. This study aims to elucidate the roles of IL-6 and IGF-1 in periodontitis-induced bone resorption and explore their therapeutic implications for periodontal health. 
The Role of IL-6 and IGF-1 in Periodontitis Bone Destruction Ikrima, Abidah; Gunawan, Erwin; Rohmah, Devi Kartika; Bachtiar, Boy Muchlis; Bachtiar, Endang Winiati
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.127-135

Abstract

Periodontitis is an inflammatory condition affecting the tissues supporting the teeth, destroying the periodontal ligament and alveolar bone. This condition is initiated by periodontal pathogens, which trigger an immune response resulting in tissue damage. Pro-inflammatory cytokines, particularly IL-6, have an important role in this process. IL-6, produced by various cells, including immune and periodontal ligament cells, enhances osteoclastogenesis by enhancing RANKL expression, thereby promoting bone resorption. Conversely, IGF-1, a hormone like insulin, is critical in bone homeostasis and regeneration. IGF-1, synthesised in the liver and locally in tissues, aids in the proliferation and differentiation of osteoblasts and osteoclasts, facilitating bone remodelling. IGF-1 also interacts with IL-6 to modulate inflammatory responses and osteoclast activity. Understanding the interplay between IL-6 and IGF-1 offers insights into the mechanism of bone resorption in periodontitis and identifies potential therapeutic targets. This study aims to elucidate the roles of IL-6 and IGF-1 in periodontitis-induced bone resorption and explore their therapeutic implications for periodontal health. 
Effect of Bacterial Metabolites From Good Oral-Hygiene to Biofilm Formation From Poor Oral-Hygiene Refyan, Sarah Athiyyahmaulidya; Ratna Ramadhani; Bachtiar, Endang Winiati; Bachtiar, Boy Muchlis; Sulistiadi, Wahyu
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 2 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i2.9030

Abstract

Introduction: Microbial variations and oral hygiene (OH) status of an individual are related to the oral biofilm formation. The metabolite of microorganisms influences biofilm formation. This research aims to analyse the effect of bacterial isolates' metabolites from a good OH individual on the in vitro biofilm of bacterial isolates from a poor OH individual. Materials and Methods: Spent medium of bacteria isolated from a good OH individual tongue swab that contains different protein and nitrate concentrations was treated in vitro with biofilm from a poor OH individual tongue swab to evaluate the cell viability and in vitro biofilm mass under aerobic conditions. The methods used include the Bradford test, Griess test, Crystal Violet test, and Total Plate Count. Results and Discussions: There were significant differences in the cell viability of bacteria isolated from poor OH individual treated by spent medium isolated from good OH individual with different concentrations of protein and nitrate (p value <0.05), as well as biofilm mass of the sample that was treated with spent medium containing different nitrate concentration (p value < 0.05). Conclusion: The protein and nitrate content in the spent medium from a good OH tongue swab can influence cell viability and in vitro biofilm mass from a poor OH individual tongue swab.
Co-Authors Endang Winiati Bachtiar Erwin Gunawan Ikrima, Abidah Lukman Hakim Makmun Natalina , Ratna Ramadhani Refyan, Sarah Athiyyahmaulidya Robert Lesang Rohmah, Devi Kartika Wahyu Sulistiadi Yulianti Kemal