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All Journal ODONTO Dental Journal Cakradonya Dental Journal Odonto dental journal
Rohmah, Devi Kartika
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Dentistry Health Professions Medicine & Pharmacology Public Health

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The Role of IL-6 and IGF-1 in Periodontitis Bone Destruction Ikrima, Abidah; Gunawan, Erwin; Rohmah, Devi Kartika; Bachtiar, Boy Muchlis; Bachtiar, Endang Winiati
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.127-135

Abstract

Periodontitis is an inflammatory condition affecting the tissues supporting the teeth, destroying the periodontal ligament and alveolar bone. This condition is initiated by periodontal pathogens, which trigger an immune response resulting in tissue damage. Pro-inflammatory cytokines, particularly IL-6, have an important role in this process. IL-6, produced by various cells, including immune and periodontal ligament cells, enhances osteoclastogenesis by enhancing RANKL expression, thereby promoting bone resorption. Conversely, IGF-1, a hormone like insulin, is critical in bone homeostasis and regeneration. IGF-1, synthesised in the liver and locally in tissues, aids in the proliferation and differentiation of osteoblasts and osteoclasts, facilitating bone remodelling. IGF-1 also interacts with IL-6 to modulate inflammatory responses and osteoclast activity. Understanding the interplay between IL-6 and IGF-1 offers insights into the mechanism of bone resorption in periodontitis and identifies potential therapeutic targets. This study aims to elucidate the roles of IL-6 and IGF-1 in periodontitis-induced bone resorption and explore their therapeutic implications for periodontal health. 
The Role of IL-6 and IGF-1 in Periodontitis Bone Destruction Ikrima, Abidah; Gunawan, Erwin; Rohmah, Devi Kartika; Bachtiar, Boy Muchlis; Bachtiar, Endang Winiati
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.127-135

Abstract

Periodontitis is an inflammatory condition affecting the tissues supporting the teeth, destroying the periodontal ligament and alveolar bone. This condition is initiated by periodontal pathogens, which trigger an immune response resulting in tissue damage. Pro-inflammatory cytokines, particularly IL-6, have an important role in this process. IL-6, produced by various cells, including immune and periodontal ligament cells, enhances osteoclastogenesis by enhancing RANKL expression, thereby promoting bone resorption. Conversely, IGF-1, a hormone like insulin, is critical in bone homeostasis and regeneration. IGF-1, synthesised in the liver and locally in tissues, aids in the proliferation and differentiation of osteoblasts and osteoclasts, facilitating bone remodelling. IGF-1 also interacts with IL-6 to modulate inflammatory responses and osteoclast activity. Understanding the interplay between IL-6 and IGF-1 offers insights into the mechanism of bone resorption in periodontitis and identifies potential therapeutic targets. This study aims to elucidate the roles of IL-6 and IGF-1 in periodontitis-induced bone resorption and explore their therapeutic implications for periodontal health. 
The Role of Veillonella in The Pathogenesis of Periodontitis: Systematic Review Rohmah, Devi Kartika; Soekanto, Sri Angky; Djais, Ariadna Adisattya; Theodorea, Citra Fragrantia; Sastradipura, Dewi Fatma Suniarti
Cakradonya Dental Journal Vol 17, No 2 (2025): Agustus 2025
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v17i2.43973

Abstract

Veillonella is a common species found in the human oral cavity that plays a significant role in biofilm ecology. Veillonella is known to play a supporting role in colonizing other, more pathogenic species. Its abundant presence in supra- and sub-gingival biofilms is thought to have an associated relationship with red-complex bacterial species. These bacteria are known to be the causative of periodontal disease. Their ability to establish this mutualistic relationship is an important factor that we need to know to expand our understanding of their relationship to the pathogenesis of periodontal disease and to develop more effective treatments.
Co-Authors Boy Muchlis Bachtiar Djais, Ariadna Adisattya Endang Winiati Bachtiar Erwin Gunawan Ikrima, Abidah Sastradipura, Dewi Fatma Suniarti Sri Angky Soekanto Theodorea, Citra Fragrantia