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All Journal Majalah Patologi Indonesia Jurnal RSMH Palembang
Eka Putra Pratama
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Mastitis Granulomatosa: Sebuah Tantangan Diagnosis Citra Dewi; Ella Amalia; Nyiayu Fauziah Kurniawati; Maria Ulfa, Maria Ulfa,; Eka Putra Pratama; Krisna Murti
Majalah Patologi Indonesia Vol 31 No 1 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.045 KB) | DOI: 10.55816/mpi.v31i1.492

Abstract

BackgroundGranulomatous mastitis (GM) is often found in reproductive-age women. These patients are treated by the administration ofantituberculosis drugs. It is difficult to determine the exact cause of GM cytologically and histopathologically. Various etiologies i.e.,tuberculosis, sarcoidosis, foreign bodies and immunological diseases may provide granulomatous inflammation features in thetissue. High-sensitivity tests such as PCR can help to detect the presence of Mycobacterium tuberculosis (MT) as one of possibleetiologic agent. Accurate diagnosis will improve the treatment quality thus a better quality of life. The aim of this study was todetermine whether the granulomatous mastitis patients who referred to the Department of Anatomic Pathology Faculty of MedicineUniversitas Sriwijaya/Dr. Moh. Hoesin Palembang Hospital were caused by MT.MethodsA descriptive observational study was performed. Thirty paraffin blocks of GM patients during the period of 1st October 2018 to 29thSeptember 2020 were collected. DNAs were extracted from tissue scrapings of the slides. Then, PCR analysis was conducted usinga specific primer IS6110 with around 200 bp PCR product.ResultsThe mean age of the patients was 40.8 years (range: 23-67 years). There were six samples (20%) of GM produced the expectedamplicon. However, only three of six samples morphologically consistent with tuberculosis.ConclusionGranulomatous inflammatory reactions in the breast are not only caused by tuberculosis. Further study is needed to determine theexact cause of this lesion. Despite high costs, PCR examination may become an alternative approach in determining the etiology ofGM.
Gastric Neuroendocrine Neoplasm : WHO Classification 2019 Eka Putra Pratama; Suly Auline Rusminan
Jurnal RSMH Palembang Vol. 1 No. 2 (2020): Jurnal RSMH Palembang
Publisher : RSUP Dr Moh Hoesin Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2164.633 KB) | DOI: 10.37275/jrp.v1i2.7

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A B S T R A C TNeuroendocrine neoplasm (NEN) of gastric is a term that includes all tumour types withneuroendocrine differentiation of gastric, well differentiated or poorly differentiatedtumour. NEN is a new term in 2019 World Health Organization (WHO) classification ofdigestive system tumours. In WHO 2019 had many updates, one of them isneuroendocrine tumours (NET) grade 3 have been included in tumour category of welldifferentiated tumour or NET. Previously, NET G3 in WHO 2010 are included as poorlydifferentiated tumour or neuroendocrine carcinoma (NEC). This neoplasm is geneticallywell differentiated and because of that, WHO 2019 classification included them as a welldifferentiated tumour. For NEC, WHO 2019 subdivided them as NEC with small cells(SCNEC) and NEC with large cells (LCNEC). In WHO 2010, mixed type neuroendocrineneoplasms with other components of carcinoma are called mixed adenoneuroendocrinecarcinoma (MANEC). But, not all of non-neuroendocrine components areadenocarcinoma and it is possible that one of the components in not carcinoma. Becauseof that, in WHO 2019 the term has been changed to mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN).
Co-Authors Citra Dewi Ella Amalia, Ella Krisna Murti Maria Ulfa, Maria Ulfa, Nyiayu Fauziah Kurniawati Suly Auline Rusminan