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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya
Siti Candra Windu Baktiyani
Laboratorium Obstetri & Ginekologi Fakultas Kedokteran Universitas Brawijaya/ RS dr. Saiful Anwar Malang
Agriculture, Biological Sciences & Forestry Environmental Science Medicine & Pharmacology

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Journal : Jurnal Kedokteran Brawijaya

 1 
PENGARUH PEMBERIAN KOMBINASI NAC DENGAN VITAMIN C DAN E TERHADAP STRES OKSIDATIF PADA HUVECs DIPAPAR PLASMA EKLAMPSIA Baktiyani, Siti Candra Windu
Jurnal Kedokteran Brawijaya Vol 23, No 3 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.873 KB) | DOI: 10.21776/ub.jkb.2007.023.03.6

Abstract

The blood plasma of preeclampsia contains oxidative stress factors. The oxidative stress is predicted asthe cause of dis-function and destruction of endothelial cell which will influence the severity of Preeclampsia and Eclampsia complications. Previous research showed that the treatment of antioxidant on preeclamsia was still controvertion. The  objectives of this research is to investigate the influence of the combination of NAC and vitamin C or vitamin E or bothof them on the level of H2O2, MDA, NO and GSH/GSSG ratio of endothelial cell culture exposed with Eclampsia plasma.The method wasan experimental study using HUVECs exposed with to 2%plasma Eclampsia as an Eclampsia model invitro. TheHUVECs were than treated with NAC 2µM only (group 1), NAC2µM + vitamin C 100 µM (group 2) , NAC 2 µM + vitamin E 100 µM (group 3), and NAC 2 µM + vitamin C 100 µM + vitamin E 100 µM (group 4) for 24 hours. The parameter measured in this study were H2O2, MDA, NO and GSH/GSSG ratio. Result showed that H2O2, MDA, and NO concentration are unsignificantly different among treatment groups although there was a decreasing on group treated with combination of NAC, vitamin C and Vitamin E.
PERBEDAAN EFEKTIFITAS PEMBERIAN VITAMIN E 100 IU DENGAN ASPIRIN 81 MG UNTUK PENCEGAHAN PREEKLAMSIA PADA PRIMIGRAVIDA Baktiyani, Siti Candra Windu; Wahjud, Imam
Jurnal Kedokteran Brawijaya Vol 21, No 3 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (647.95 KB) | DOI: 10.21776/ub.jkb.2005.021.03.3

Abstract

Preeclampsia is a specific disturbance of human pregnancy, that diagnosed by the onset of hypertension and proteinuria in the third trimester. It occurs more in developing countries, due to the fact that developed countries have better prenatal care. The objective of this study was to assess the difference effectiveness of preventing preeclampsiaand giving vitamin E 100 iu and aspirin 81 mg. This study used prospective with single randomaised clinical trial. The place of this study is on Maternity care unit of RSUD Dr. Saiful Anwar Malang from October 2000 to October 2001. Fourty samples primigravidas between the age of 19-35 years were used in this study. Twenty four samples were treated  with vitamin E and 24 samples were treated with aspirin started atthe eighteenth weeks of pregnancy until delivery.  The changes, of blood presure, albuminuri and oedema were observed.The result showed that during the observation the incidence rate of mild preeclampsia of vitamin E was 4 samples or(16,7%), mild preeclampsia was 1 sample or (14,2%)by the time of the normal delivery. On the other hand, the mild preeclampsia of the control group of aspirin was 3 samples or (12,5%) and mild preeklampsia was 2 samples or (8,3%) at  the normal delivery. There is no significant difference in preeclampsia occurance between vitamin E and aspirin group. Key words: Vitamin E, Aspirin, preeclampsia
Co-Authors Abd. Rasyid Syamsuri Bambang Rahardjo Bramantyo Aji Wicaksono, Bramantyo Aji Imam Wahjud Loeki Enggar Fitri Sri Winarsih Zahariah, Sultanah