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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Majalah Kedokteran Bandung Jurnal Keperawatan Jiwa (JKJ): Persatuan Perawat Nasional Indonesia Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Warta Ardhia : Jurnal Perhubungan Udara Medical Laboratory Technology Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Care : Jurnal Ilmiah Ilmu Kesehatan Journal of Issues in Midwifery Heart Science Journal Devotion: Journal of Research and Community Service Narra J Indonesian Journal of Perinatology Asian Journal of Health Research Jurnal Info Kesehatan
Bambang Rahardjo
Faculty Of Medicine Universitas Brawijaya Dr. Saiful Anwar General Hospital Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Transportation Veterinary

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Kehamilan dengan Katub Jantung Prostetik Mekanik dan Penggunaan Antikoagulan Indriani, Anin; Rahardjo, Bambang; Tjahjono, Cholid Tri
Journal of Issues in Midwifery Vol 2, No 1 (2018)
Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.65 KB) | DOI: 10.21776/ub.JOIM.2018.002.01.2

Abstract

Wanita hamil yang menggunakan katub jantung prostetik mekanik, meningkatkan morbiditas dan mortalitas terhadap ibu dan janin. Heparin sangat aman bagi janin dibandingkan warfarin, namun memiliki efek antikoagulasi yang lebih rendah dibandingkan warfarin. Studi kasus ini melaporkan seorang wanita 39 tahun dengan katub jantung prostetik mekanik yang mengalami kehamilan setelah 2 tahun pemakaian. Selama kehamilan penderita menggunakan antikoagulan warfarin. pada usia kehamilan 5 minggu psien mengalami abortus iminens namun bisa diatasi. Pada usia kehamilan 22-24 minggu pasien mengalami serangan asma namun dapat diterapi dengan baik. Selanjutnya pasien menentukan cara persalinan perabdominam pada usia kehamilan 38 minggudilanjutkan dengan prosedur tubektomi. Hasil akhir dari tatalaksana yang digunakan, didapatkan outcome yang baik terhadap ibu maupun janin. Tidak didapatkan tanda–tanda embriopati akibat penggunaan warfarin pada trimester pertama. Dari studi kasus ini juga tampak bahwa warfarin cukup efektif untuk mencegah terjadinya tromboemboli pada ibu, dan pemakaian UFH dapat digunakan sebagai alternatif untuk persiapan persalinan.
Toxicity Test on Wedusan (Ageratum spp.) Extract Against Sitophilus spp. (Coleoptera: Curculionidae) Mosip, Erinus; Rahardjo, Bambang; Astuti, Ludji
Journal of Tropical Life Science Vol 8, No 1 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (734.525 KB)

Abstract

Tropical condition in Southeast Asia has contributed around 30% of post harvest damage as it provide optimum condition for the growth of Sitophilus spp. pest. Therefore, this study was aimed to investigate the effect of wedusan extract on controlling Sitophilus spp. Growth. Wedusan extract was given in different level of concentrations. The research used the Randomized Complete Design. Wedusan (Ageratum spp.) extract affected the imago mortality of Sitophilus spp. There were two kinds of Wedusan extract used in this study, dried extract (DE) and fresh extract (FE).  Sitophilus imago were put into bottles filled with organic rice and were treated with Wedusan extract. The mortality level was obsered at 24 Hours After Application (HAA), 48 HAA, and 72 HAA. The highest toxicity was found by the treatment of dried extract of wedusan 5 tablets, by LC50 55% on 24 HAA and 82.25% on 72 HAA. Extract of dry matter has higher toxicity effect than fresh extract. The application of wedusan extract is eviromental friendly and specific-range against pest. It is promising for future development as natural product in agriculture area.
The Effect of Turmeric Decoctum to the Angiogenic Molecules Expression on Chicken Embryo Zahariah, Sultanah; Winarsih, Sri; Baktiyani, Siti Candra Windu; Rahardjo, Bambang; Kalsum, Umi
Journal of Tropical Life Science Vol 7, No 1 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.01.10

Abstract

Turmeric (Curcuma longa) is widely used as herbal medicine, not an exception by pregnant women. Turmeric consumption by expectant mothers requires standard dose, because of its antiangiogenic effect could be harmful on placentation process and embryonic development. This experiment was undertaken to determine the effect of different concentrations of turmeric decoctum to the expression of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) and Angiopoietin 1 (Ang-1) on the 48-hours-old chicken embryo. In this study, turmeric was extracted using decoction method to mimic the common method as adopted by people. The turmeric decoctum were freeze dried into a powder form and was used in preparing the stock solution for 200 ppm (P1), 300 ppm (P2), and 400 ppm (P3) as experimental treatments. The control group (P0) received 2% DMSO without turmeric decoctum. These were administered on the yolk sack of 16 hours incubation of fertile chicken egg by number of 200 µL. After 48 hours incubation, the expression of VEGFR-2 and Ang-1 on the chicken embryo were counted by ImageJ software. The results revealed that there is no significant effect of turmeric decoctum to the expression of VEGFR-2 and Ang-1. This suggested that turmeric decoctum was safe up to 400 ppm on chicken embryo.
Pengaruh Pemberian Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) Menghambat Flexi Cranial Embrio Ayam Umur 48 Jam Anggraeni, Yessy Mulyanur; Rahardjo, Bambang; Rahayu, Indriati Dwi
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Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2020.004.03.3

Abstract

Embryonic development forms three layers of germinativum that is endoderm, mesoderm and ectoderm. At the beginning of intrauterine fetus exchange of substances through diffusion, but in line with the development of the embryo, nutrition is not obtained through diffusion alone. Endoderm lining mesoderm cells will then be formed angioblasts as an early sign of vascularity. In the development of flexi cranial can be known from the development of the brain and heart which is characterized by bending the head of the embryo and decreased heart from the cranial down. The development of a normal vascular system will have an effect on organogenesis and morphogesis processes. If there are disturbances in the process of growth and development at that stage can cause congenital abnormalities. Xanthones mangosteen peel is rich in benefits, but in research on the effects of xanthones on embryos is still very limited and has not been able to explain their effects on the condition of the fetus. The study was conducted with the aim to determine the effect of mangosteen peel extract inhibiting the flexi cranial of 48 hours chicken embryos using doses of 100 µg/mL, 150 µg/mL and 200 µg/mL. Mangosteen peel extract is injected into chicken eggs less than 7 days after oviposition then incubated for 48 hours. The results showed that mangosteen peel extract inhibited flexi cranial of chicken embryos with Chi-Square test results (p = 0.002). The conclusion of the study was that exposure to mangosteen peel extract inhibited flexi cranial and gave significant results.
PENGARUH PEMBERIAN AIR REBUSAN BIJI ALPUKAT (Persea americana Mill) TERHADAP PERTUMBUHAN JAMUR Candida albicans SECARA IN VITRO Amir, Nayla Nabilla Tahta Avwina; Winarsih, Sri; Rahardjo, Bambang
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Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2021.005.02.3

Abstract

The most common cause of patalogis leucorrhoea is infection, one of which is Vulvovaginal Candidiasis (VVC) caused by fungus, while 80% -90% is caused by Candida albicans. Approximately 90% of young women in Indonesia have the potential to experience vaginal discharge because Indonesia is a tropical climate. Alternative treatment for antifungal drugs is needed through the exploration of natural material sources that have the potential as antifungals to deal with this infection safely and easily. The design used in this study was experimental research by in vitro using the dilution method of the tube. Treatment concentrations are 45%; 40%; 35%; 30%; 25%; 20%, 15% and 0% with Candida albicans 104 CFU / ml samples from the microbiology lab of the medical faculty Brawijaya University and repeated 3 times. The result showed that at all concentrations, growth was still obtained in agar media so that it could be denied that the boiled water of avocado seeds had no effect on the growth of Candida albicans fungal colonies in vitro because there were still fungal colonies on the plates.
Effect of Propolis on the Adhesion Index, Morphology and Viability of Candida albicans Cells on Biofilm Formation Dinda Oktia Maghfiroh; A.A. Santi Dewi; Anggie Diniayuningrum; Bambang Rahardjo; Nurdiana Nurdiana; Agustina Tri Endharti; Sumarno Sumarno
Medical Laboratory Technology Journal Vol. 7 No. 1 (2021): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.321 KB) | DOI: 10.31964/mltj.v7i1.322

Abstract

Approximately 70-75% of reproductive women have experienced vulvovaginal candidiasis at least once, and 40-45% will have recurrences. Candida albicans is the most etiology of vulvovaginal candidiasis and is able to form a biofilm that can lead to antifungal resistances and recurrences. One of the natural products that have an anti biofilm effect is propolis. This study expected that propolis from Lawang can be one of the anti-biofilm agent candidates for antifungal resistant cases. This study aimed to know the anti-biofilm effect of propolis ethanol extract on cell adhesion index, morphology, and viability of Candida albicans cell on biofilm formation. The adhesion index was counted on 100 epithelial cells under light microscopy (1000x). Morphology was seen using light microscopy (400x). Cell viability was examined by CFU assay. At 12.5% concentration of propolis ethanol extract, adhesion index decreased (p=0,000), and hyphal growth was inhibited. Colony growth decreased at 2.5% concentration and was not seen at 10% concentration of propolis ethanol extract (p=0,000). These results indicated that propolis ethanol extract could decrease adhesion index, failed the Candida albicans morphology transition from yeast to hyphal, and decreased Candida albicans cell viability on biofilm formation. Propolis ethanol extract is likely to be one of the alternatives to recurrent vulvovaginal candidiasis treatment, especially caused by Candida albicans biofilm formation.
Aromaterapi Lavender Menurunkan Skor Edinburgh Postpartum Depression Scale pada Ibu dengan Postpartum Blues Erna Amin; Bambang Rahardjo; Kusworini Kusworini
Jurnal Keperawatan Jiwa (JKJ): Persatuan Perawat Nasional Indonesia Vol 9, No 3 (2021): Agustus 2021
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jkj.9.3.2021.589-596

Abstract

Pendokumentasian kejadian postpartum blues belum banyak dilakukan oleh fasilitas pelayanan kesehatan di Indonesia. Dari hasil penelitian sebelumnya, kejadian postpartum blues mencapai 74,4%. Kondisi ini harus menjadi perhatian karena 10-18% dapat berkembang menjadi depresi postpartum yang memiliki dampak negative terhadap kesehatan ibu serta mempengaruhi interaksi antara ibu dan bayinya. Tujuan penelitian ini yaitu untuk mengetahui pengaruh aromaterapi lavender terhadap skor EPDS  ibu dengan postpartum blues. Penelitian quasi eksperimen dengan desain Pretest-Posttest Control Group yang dilakukan pada April s/d Mei 2019 di 3 Puskesmas. Populasi dalam penelitian ini adalah ibu yang mengalami postpartum blues di tiga Puskesmas lokasi penelitian berdasarkan hasil skrining sebanyak 33 orang. Sampel dipilih dengan menggunakan metode non probability sampling yaitu dengan purposive sampling sehingga didapatkan sampel sebanyak 28 orang dibagi dalam 2 kelompok yaitu kelompok perlakuan dan kontrol. Grup intervensi diberikan aromaterapi lavender sebanyak 5 tetes pada kapas yang dihirup selama 15 menit sebanyak dua kali dalam seminggu selama 4 minggu. Data skor EPDS dianalisis menggunakan Wilcoxon signed-ranks test. Hasil analisis menunjukkan tidak ada perbedaan yang bermakna skor EPDS pada kelompok kontrol (p=0,410> 14∝"> ). Sedangkan pada kelompok perlakuan (p=0,001< 14∝"> ), menunjukkan terdapat perbedaan yang bermakna sebelum dan setelah pemberian aromaterapi lavender. Dalam penelitian ini, diketahui bahwa aromaterapi lavender dapat menurunkan skor EPDS pada ibu yang mengalami postpartum blues sehingga efektif untuk mengatasi kejadian postpartum blues.
Effects of per oral cypermethrin exposure on Bcl-2 expression in granulose cells and antral follicle count of Rattus norvegicus ovaries Indrayanti Indrayanti; Bambang Rahardjo; Hidayat Sujuti
Majalah Obstetri dan Ginekologi Vol. 26 No. 3 (2018): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.602 KB) | DOI: 10.20473/mog.V26I32018.123-127

Abstract

Objectives: To determine the effect of oral cypermethrin exposure on the decrease of Bcl-2 expression in granulosa cells and antral follicle count in Rattus norvegicus ovary.Materials and Methods: This was a true experimental study using post-test control group design. This study used 24 Rattus norvegicus which were divided into 4 groups, the control group, treatment group (P1) exposed to cypermethrin 10 mg/kg BW, treatment group (P2) exposed to cypermethrin 15 mg/kg BW and treatment group (P3) exposed to cypermethrin 20 mg/kg BW. The treatment groups were exposed to cypermethrin for 28 days. A surgery was conducted in proestrus phase and ovarian organs were taken. Bcl-2 expression examination was performed by using immunohistochemical method and the antral follicle count was assessed with the Hematoxillin Eosin (HE)Results: This study showed the decrease of Bcl-2 expression in cypermethrin-exposed group compared to control group. There was a decrease in antral follicles count in cypermethrin-exposed group compared to control group.Conclusion: Cypermethrin can decrease Bcl-2 expression and antral follicles count in Rattus norvegicus ovaries.
Risk of Malignancy Index 4 (RMI4) and Risk of Malignancy Index 3 (RMI3) as Diagnostic Tests for Adnexal Tumor: Risk of Malignancy Index 4 (RMI4) dan Risk of Malignancy Index 3 (RMI3) sebagai Alat Diagnostik untuk Tumor Adneksa Tatit Nurseta; Yahya Irwanto; Nugrahanti Prasetyorini; Bambang Rahardjo; I Wayan Subage
Indonesian Journal of Obstetrics and Gynecology Volume 8 No. 4 October 2020
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v8i4.1342

Abstract

Objective: Comparing scoring with RMI3 and RMI4 in establishing the diagnosis of adnexal tumour in RSUD Dr. Saiful Anwar Malang.Methods: Prospective cohort study with samples of all patients suspected of having an adnexal tumour diagnosed in gynecology policlinic using gynecological oncology policlinic medical records at RSUD Dr. Saiful Anwar in the form of age, demographics, menopause status, Ca125, ultrasound results.Results: Between the RMI3 results and the results of histopathology, a contingency coeffi cient of 0.596 was obtained with a p-value of 0.000015 (p <0.05), with a PPV of 83%, an NPV of 91%. Between the RMI4 results and the histopathology results, a contingency coeffi cient of 0.657 with a p-value of 0.0000004 (p <0.05) was obtained, with a PPV of 92%, NPV of 95%. On the ROC curve, the area of the predicted results using the RMI4 score is higher than the RMI3 score.Conclusions: Using the RMI4 score results in more accurate predictions than the RMI3 score in detecting adnexal tumour malignancies.Keywords: adnexal tumours, diagnostic tests, ovarian tumours, risk of malignancy index, ultrasound. Abstrak Tujuan: Membandingkan Skoring RMI3 dan RMI4 dalam menegakkan diagnosis tumor adneksa di RSUD dr. Saiful Anwar Malang.Metode: penelitian kohort prospective dengan sampel semua pasien yang dicurigai menderita tumor adneksa yang didiagnosis di poli Ginekologi menggunakan data rekam medis poli Ginekologi Onkologi RSUD dr. Saiful Anwar berupa usia, demografi , status menopause, Ca125, hasil USG.Hasil: Antara hasil RMI3 dengan hasil hispatologi, didapatkan koefi sien kontingensi sebesar 0,596 dengan p-value 0,000015 (p<0,05), dengan PPV 83%, NPV 91%. Antara hasil RMI4 dengan hasil histopatologi, didapatkan koefisien kontingensi sebesar 0,657 dengan p-value 0,0000004 (p<0,05), dengan PPV 92%, NPV 95%. Pada kurva ROC, luas area hasil prediksi dengan menggunakan skor RMI4 lebih tinggi daripada skor RMI3.Kesimpulan: Menggunakan skor RMI4 menghasilkan prediksi yang lebih tepat daripada skor RMI3 dalam mendeteksi keganasan tumor adneksa.Kata kunci: risk of malignancy index, tumor adneksa, tumor ovarium, uji diagnostik, USG.
Effect of Pravastatin on eNOS and PECAM-1 Expression in the Placenta of Pre-Eclampsia Rat (Rattus norvegicus) Model Bambang Rahardjo; Kunawati Tungga Dewi; Anita Dwi Rahmawati; Fauqo Wildatil Jannah; Mukhamad Nooryanto; Anin Indriani
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (992.174 KB) | DOI: 10.55561/ajhr.v1i2.44

Abstract

Introduction: Preeclampsia has two stages: improper placental and maternal circulation. Abnormal trophoblast invasion causes uteroplacental ischemia and hypoxia. Ischemia in the placenta produces endothelial cell dysfunction, which is defined by a change in endothelial cell activity to a reduced ability to vasodilate (decreased eNOS) and prothrombotic conditions (decreased PECAM-1). Reduced maternal eNOS activity and PECAM-1 can cause preeclampsia. Pravastatin is the statin class's most hydrophilic medication, and it limits placental transfer. Pravastatin can reduce endothelial dysfunction by targeting pleiotropic effects in pregnancy. The aim was to show the effects of pravastatin on the eNOS and PECAM-1 expression in the placenta of preeclampsia rat model. Materials and Methods: This is a true experimental study with only a post-test and a control group design. The sample was biological material in the form of placental tissue from a pravastatin-treated preeclampsia rat model (using L-NAME exposure). This research was divided into five groups, each with five samples. The parameters studied were eNOS and PECAM-1 expression. Results: The Shapiro-Wilk test result was significant (p>0.05). Annova tests on eNOS (p=0.000) and PECAM-1 expression (p=0.000) confirmed the hypothesis. The Tukey test showed significant differences in eNOS (sig. 0.001) and PECAM-1 (sig. 0.000) expression between normal and preeclampsia rats. Positive controls and treatment groups P1, P2, and P3 all showed significant changes in eNOS and PECAM-1 expression. Pravastatin dose considerably increased eNOS (p=0.015; r=0.536) and PECAM-1 (p=0.000; r=0.734) expression.. Conclusion: Pravastatin has been shown to increase eNOS and PECAM-1 expression in the placenta of preeclampsia rat model.
Co-Authors A.A. Santi Dewi Abd. Rasyid Syamsuri Agustina Tri Endharti Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Alim, Fathi Nabila Aloysius Suryawan Amir, Nayla Nabilla Tahta Avwina Andonotopo, Wiku Anggie Diniayuningrum Anggraeni, Yessy Mulyanur Anik Sri Purwanti Anin Indriani Anisa Setyowati Anita Dwi Rahmawati Annisa Jusuf, Annisa Annissa Febriani Astuti, Ludji Aziz, Ali Bachnas, Muhammad Adrianes Baihaqi, Irfani Cholid Tri Tjahjono Cut Meurah Yeni Daniati, Lidya Dewi Azar Nuria Wardani Dewi, Ratih Frastika Dinda Oktia Maghfiroh Edy Mustofa Erna Amin Evert Solomon Pangkahila Fauqo Wildatil Jannah Gusti, Kharisma Ciptaning Harumsari, Stefani Hery Setiawan, Hery Hidayat Sujuti Hikmawan Wahyu Sulistomo I Nyoman Hariyasa Sanjaya I Wayan Subage Ihda Dian Kusuma Ihda Dian Kusuma Indrayanti Indrayanti Indriani, Anin Indriati Dwi Rahayu Irfani Baihaqi Ita Sulistiani Julian Dewantiningrum Kalsumy, Umi Kharisma Ciptaning Gusti Kurjak, Asim Kusworini Handono Lestari, Ni Putu Yunita Sri Lilik Zuhriyah Ludji Astuti Melani Chysti Situmorang Mohammad Saifur Rohman Mosip, Erinus Mukhamad Nooryanto Noviyanti Noviyanti, Noviyanti Nugrahanti Prasetyorini Nur Sophia Matin Nurdiana Nurdiana Nurdiana Nurdiana Nurdiana Nurdiana Nuswil Bernolian Pande Made Dwijayasa Permatasari, Galuh W. Pramono, Mochammad Besari Adi Pratama, Harry Dwi Purba, Irene Silvia Purbandari, Rosalia Puspita Handayani Putra, Ichsan Setya Ratnawati, Linda Regina Ayu Fristiyanti Ryan Saktika Mulyana Sabilla Khaerunissa, Dymphna Safrina Dewi Ratnaningrum Sanarto Santoso Sanggelorang, Margie Cassie Setyowati, Anisa Sirat, Noorhamdani A. Siti Candra Windu Baktiyani Siti Candra Windu Baktiyani Situmorang, Melani Chysti Sri Poeranto, Sri Sri Sulistyowati Sri Winarsih Stanojevic, Milan Subandi Subandi Sugiono, Achmad Sulistiani, Ita Sulistomo, Hikmawan Wahyu Sultanah Zahariah Sumarno . Sumarno Sumarno Sutrisno Sutrisno Talita Nandia Primarintan Tatit Nurseta Tatit Nurseta Theresia Monica Rahardjo Udjianto, Udjianto Wardani, Dewi Azar Nuria Wardani, Diadjeng Setya Wardani, Widya Kusuma Wati, Linda Ratna Wibisono, Hermawan Widyalaksono, Agung Winasih, Sri Wiradnyana, Anak Agung Gede Putra Wiyasa, I Wayan Arsana Yahya Irwanto Yogibuana, Valerinna Yuyun Yueniwati Zahariah, Sultanah