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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya
Siti Candra Windu Baktiyani
Laboratorium Obstetri & Ginekologi Fakultas Kedokteran Universitas Brawijaya/ RS dr. Saiful Anwar Malang
Agriculture, Biological Sciences & Forestry Environmental Science Medicine & Pharmacology

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The Effect of Turmeric Decoctum to the Angiogenic Molecules Expression on Chicken Embryo Zahariah, Sultanah; Winarsih, Sri; Baktiyani, Siti Candra Windu; Rahardjo, Bambang; Kalsum, Umi
Journal of Tropical Life Science Vol 7, No 1 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.01.10

Abstract

Turmeric (Curcuma longa) is widely used as herbal medicine, not an exception by pregnant women. Turmeric consumption by expectant mothers requires standard dose, because of its antiangiogenic effect could be harmful on placentation process and embryonic development. This experiment was undertaken to determine the effect of different concentrations of turmeric decoctum to the expression of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) and Angiopoietin 1 (Ang-1) on the 48-hours-old chicken embryo. In this study, turmeric was extracted using decoction method to mimic the common method as adopted by people. The turmeric decoctum were freeze dried into a powder form and was used in preparing the stock solution for 200 ppm (P1), 300 ppm (P2), and 400 ppm (P3) as experimental treatments. The control group (P0) received 2% DMSO without turmeric decoctum. These were administered on the yolk sack of 16 hours incubation of fertile chicken egg by number of 200 µL. After 48 hours incubation, the expression of VEGFR-2 and Ang-1 on the chicken embryo were counted by ImageJ software. The results revealed that there is no significant effect of turmeric decoctum to the expression of VEGFR-2 and Ang-1. This suggested that turmeric decoctum was safe up to 400 ppm on chicken embryo.
Intraperitoneal Injection of High Tumor Necrosis Factor (TNF-α) Serum Increase Soluble Fms-like Tyrosine Kinase-1 (sFlt-1) and Blood Pressure of Pregnant Mice Wicaksono, Bramantyo Aji; Baktiyani, Siti Candra Windu; Fitri, Loeki Enggar
Journal of Tropical Life Science Vol 5, No 2 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.05.02.01

Abstract

Preeclampsia has major symptoms of hypertension and proteinuria and is a cause of significant maternal and infant mortality in the world. The slow development of preeclampsia research possibility caused by the difficulty in acquiring animal preeclampsia. Many existing animal model have been developed, but most of them are expensive to do. The purpose of this study was to determine the effects of intraperitoneal injection of pregnant patients serum with high TNF-α levels toward sFlt-1 serum concentration and blood pressure of pregnant mice. Pregnant patients serum with high TNF-α levels (>20 pg/mL) was injected intraperitoneally to pregnant mice at gestational age 13 and 14 days. At 18 days of gestation, the blood pressure was measured, then the mice were dissected and the serum was taken to measure serum sFlt-1 concentration using ELISA kit(Bioassay Technology Laboratory, E0611Mo). The results showed there was a significant increase in blood pressure (p = 0.000) and the sFlt-1 levels (p = 0.002) of pregnant mice group that injected by pregnant patient serum with high TNF-α levels compare to control group. From these data it can be concluded that intraperitoneal injection of pregnant patients serum with high TNF-α levels to pregnant mice can increase blood pressure and sFlt-1 serum concentration of mice.
Co-Authors Abd. Rasyid Syamsuri Bambang Rahardjo Bramantyo Aji Wicaksono, Bramantyo Aji Imam Wahjud Loeki Enggar Fitri Sri Winarsih Zahariah, Sultanah