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All Journal Indian Journal of Forensic Medicine & Toxicology
Anuja Agrawal
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Comparative Study of Magnesium Sulphate added to Bupivacaine and Ropivacaine Local Infiltration of Wound for Postoperative Analgesia in Patients Undergoing Upper Abdominal Surgery: A Randomized Double Blind Study Anuja Agrawal; Sujay Thakkar; Akhilesh Chhaya; Malini Mehta
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14277

Abstract

Aim: To compare subcutaneous infiltration of Inj Bupivacaine with inj MgSO4and Inj Ropivacaine withInjMgSO4 for postoperative analgesia undergoing upper abdominal surgery. Goal: To determine duration ofanalgesia, doses of rescue analgesia, VAS at different time intervals.Background: Post-operative pain is most neglected entity. We should use availableresources inoptimummanner for improving pain managementstrategies.Methods: A Prospective, double-blinded, randomized studyof 50 patients undergoing upper abdominalsurgery divided into group B and R. Infiltration was done in the subcutaneous plane by surgeon before skinclosure. Group B: Inj. Bupivacaine 50mg (10ml of 0.5% Inj . Bupivacaine) with Inj.MgSO4 500mg (1ml ofInj 50% MgSO4) diluted with NS 9 ml to make total volume of 20 ml whereas, Group R: Inj Ropivacaine50 mg (6.7 ml of 0.75% Inj. Ropivacaine) with Inj MgSO4 500 mg diluted with NS (12.3 ml) making a totalvolume of 20 ml. In postoperative period, parameters noted were vitals and Visual Analogue Score (VAS)for 24 hours.Results: In group R, moderate pain was seen in 40%of the patients at T12 whereas in group B 48% hadmoderate pain. Total no. of rescue analgesic doses required in Group R is 2.1 +/- 0.5 and in Group B is 2.6+/- 0.5 in 24 hrs and has significant differencestatistically.Conclusion: Group R had better VAS scores at T24 and reduced no.of rescue analgesic doses.
An Observational Study of the Effect of Dexmedetomidine on Haemodynamic and Airway Responses During Extubation of Trachea Following Major Surgery Under General Anaesthesia Anuja Agrawal; Riddhi Shah; Kirti Patel; Pooja Shah; Dinesh Chauhan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15285

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An Observational Study of Intravenous Dexmedetomidine and Clonidine for Attenuating Haemodynamic Response to Laryngoscopy and Intubation in Patients Undergoing General Anaesthesia Priya Kishnani; Sanam Shah; Jayshri Desai; Anuja Agrawal
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15898

Abstract

Background: Laryngoscopy and endotracheal intubation alters cardiovascular physiology causinghypertension and tachycardia. Dexmedetomidine, an alpha 2 adrenergic receptor produces analgesiaby direct activation of descending inhibitory pain pathway and inhibiting the release of substance P.Clonidine a centrally acting alpha 2 adrenergic agonist decreases central sympathetic nervous system in allhyperadrenergic situations. Hence we compare haemodynamic effects between dexmedetomidine 0.5 mcg/kg and clonidine 1mcg/kg during after laryngoscopy and tracheal intubation for patients undergoing generalanaesthesia.Method: Patients were allocated randomly into 2 groups of 30 each. Group D received dexmedetomidine0.5mcg/kg diluted in 10ml NS and group C- clonidine 1 mcg/kg diluted in 10ml NS intravenously andhemodynamic parameters were observed. Dexmedetomidine/ Clonidine according to groups is givenintravenously with premedication. After 5 minutes patients were induced with 2.5% thiopentone 5-7 mg/kgand succinyl choline 2mg/kg and intubated with appropriate sized cuffed ETT. Anaesthesia was maintainedwith O2, N2O, isoflurane and vecuronium bromide 0.08mg/kg.Results: Haemodynamic changes after laryngoscopy and intubation were recorded at baseline, premedication,induction, intubation, 1, 3, 5,10 and 15 minutes. The initial fall in HR is more in Group C compared to GroupD but the difference was insignificant, but since intubation till 10min post intubation HR was significantly(p<0.05) supressed more in Group D. Similarly fall in SBP and DBP is significantly (p<0.05) more in GroupD compared to Group C.Conclusion: Dexmedetomedine 0.5 mcg/kg intravenously 15 minutes prior to laryngoscopy and intubationattenuates the sympathetic response better as compared to clonidine without major side effects.
Co-Authors Akhilesh Chhaya Dinesh Chauhan Jayshri Desai Kirti Patel Malini Mehta Pooja Shah Priya Kishnani Riddhi Shah Sanam Shah Sujay Thakkar