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All Journal Journal of Agromedicine and Medical Sciences Indian Journal of Forensic Medicine & Toxicology
Masruroh Rahayu
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Health Professions Public Health

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In Silico Prediction of Potential Compounds of Nigella sativa as Aromatase Agonists and Ability to Cross the Blood-Brain Barrier for treatment of Alzheimer’s Disease Kusuma Andriana; Nurdiana; Wisnu Barlianto; I Wayan Arsana Wiayasa; Masruroh Rahayu
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14321

Abstract

Background: Alzheimer’s disease (AD), is a chronic neurodegenerative disease which condition ischaracterized by a decline in memory, thinking skills, and the ability to perform basic activities of dailyliving. Study showed that postmenopausal women with AD had a lower aromatase activity (p450 aromatase)in the brain compared to menopausal women without AD. To improve cognitive function in AD patients,Nigella sativa (NS) was found to have a protective effect on memory, and cognitive function. This studytherefore, aimed to investigate in silico prediction of potential compounds of Nigella sativa as aromataseagonists and ability to cross the Blood-Brain Barrier (BBB) for treatment of Alzheimer’s Disease. Methods:The data sets used in this study were collected from databases KnapSack Kanaya, PubChem, and PASSserver Way2Drug. HitPick and Autodock Vina was performed. Additionally, the systematic analysisinvolved ADMET, LMMD, and SWISS ADME. Results and Discussions: In silico test results revealed themost promising constituents in 36 active NS compounds that may have potential to reduce the severity ofthe AD, owing to its anti-inflammatory, cytochrome p450 stimulants, free radical scavengers, antioxidants,and immunomodulators. The ability of NS to cross the BBB was proven by admetSAR LMMD with ananalysis average value of 0.91 (from the highest value of 1). Further, NS can trigger cytochrome P450aromatase activity via Quercetin 3-(6’’ ‘’-feruloylglucosyl)-(1->2)-galactosyl-(1->2)-glucoside which has abetter binding affinity value than its control (androstenedione). NS through oleic acid compounds may bindto peroxisome proliferator-activated receptor gamma (PPRAG), similar to Rosiglitazone which may affecttranscription and activation regulation of PPARG. Conclusion: To be concluded, Nigella sativa could beused as a potential medicinal plant for the treatment of Alzheimer’s disease.
Identification and In Silico Analysis of Anti Inflammation and Anti Oxidant Potentials of Polyphenol Compounds in Methanol Extract of Tamarindus indica Seeds Muhammad Ihwan Narwanto; Masruroh Rahayu; Setyawati Soeharto; Nurdiana Nurdiana; Moch. Aris Widodo
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6735

Abstract

ABSTRACT Indonesia has abundant stock of Tamarindus indica seeds, but it is not yet utilized maximally, especially in medical field. Tamarindus indica seeds have high content of polyphenols compound. No reseacrh is supported by in silico data on polyphenol compound in Tamarindus indica seeds extract. Polyphenols compound can be utilized as a neuroprotective agent. This research aims to measure polyphenols concentration in methanol Tamarindus indica seeds extract and determine the anti inflammation and antioxidant potential of each polyphenol compound in methanol Tamarindus indica seeds extract by in silico method. The extraction of Tamarindus seeds used maceration method and methanol as solvent. Identification and measurement of polyphenols compound applied HLPC-MS. PyMol and Pyrx tools were used for in silico analysis. Extract recidu was obtained from methanol Tamarindus indica seeds as much as 12%w/v. HPLC-MS anaysis mentioned that levels of procyanidin B2, myricentin and caffeic acid were respectively 38.850 mg/kg, 5.845 mg/kg and 260 mg/kg. The highest anti inflammatory potential was owned by myricentin than caffeic acid, while the lowest potential in procyanidin B2. Furthermore, the highest antioxidant potential was sequentially in myricentin, procyanidin B2 and caffeic acid. It is very possible to utilize methanol Tamarindus indica seeds extract for preventing neurodegenerative diseases since its pathogenesis involves inflammatory and stress oxidative process. Keywords : Tamarindus indica, myricetin, procyanidin B2, caffeic acid, anti inflammatory, antioxidant
The extract of kemangi leaves as inhibitor of biofilm from Staphylococcus aureus in vitro Putu Sri Maharani Utami; Noorhamdani Noorhamdani; Masruroh Rahayu
Journal of Agromedicine and Medical Sciences Vol 6 No 3 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i3.17541

Abstract

Biofilm is a mechanism of bacterial defense against antimicrobials that can cause resistance. Staphylococcus aureus is a biofilm-producing bacteria and the most often cause of skin and soft tissue infections. Therefore, efforts are needed to prevent the formation of Staphylococcus aureus biofilms. Basil leaves are herbal plants that contain eugenol and tannin compounds, which are thought to inhibit the formation of biofilms. This research is a laboratory experimental study that aims to prove the effect of basil leaves ethanol extract (Ocimum sanctum) on the establishment of Staphylococcus aureus biofilms with in vitro method and determine the minimum inhibitory biofilm concentration needed. In this study, the tube method with 7 different concentrations was used. The results of biofilm ring formation obtained and measured quantitatively using Mean Gray Value in Adobe Photoshop CS6. From the study’s results, is found that the increase in extract concentration is directly proportional to the thinning of the biofilm ring on the tube with a minimum inhibitory concentration of biofilm at a concentration of 30%. The Pearson correlation test showed a very strong and significant correlation (r = 0.898, p = 0,000), and the Oneway ANOVA comparison test known a significant difference among the mean of each group (p = 0,000). From these results it can be known that the ethanol extract Ocimum sanctum can inhibit the formation of Staphylococcus aureus biofilms in vitro.
Co-Authors I Wayan Arsana Wiayasa Kusuma Andriana M. Ihwan Narwanto Moch. Aris Widodo Noorhamdani Noorhamdani Nurdiana Nurdiana Nurdiana Putu Sri Maharani Utami Setyawati Soeharto Wisnu Barlianto