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Widhi Bodhi
Universitas Sam Ratulangi
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HUBUNGAN TEKANAN DARAH DENGAN OBESITAS PADA REMAJA OBES DAN NON-OBES DI KABUPATEN BOLAANG MONGONDOUW UTARA Ratulangi, Andrew Johanes; Bodhi, Widhi; ., Fatimawali; Manampiring, Aaltje
JKK (Jurnal Kedokteran Klinik) Vol 1, No 1 (2016): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstract: Hypertension is a non-infectious disease that is caused by many factors. Obesity is one of these factors causing hypertension, and the prevalence is increasing everyday. This study aims to see the relation of blood pressure and obesity of teenagers in North Bolaang Mongondow. This study design is a cross sectional analytic. Study sample is SMP, SMA, and MTS student in North Bolaang Mongondow. From 60 respondents, 29 were obese and 30 were not. The blood pressure of these samples was measured and the relation between blood pressure and IMT was analyzed. Result of the study that was analyzed with mann-withney test shows no significant relation between obesity and systole and diastole blood pressure (p = 0,413, p = 0,938 ; p > 0,05). With spearman correlation test, it was found that there is a very low correlation and no relation between obesity and systolic blood pressure (rs=  -0,082, p=0,536) and it was found that there is a very low correlation and no relation between obesity and diastolic blood pressure (rs=0,010, p=0,939) Conclussion: based on study that was done in SMP, SMA, and MTS in North Bolaang Mongondow it was found that there is no correlation between blood pressure and obesity. Further study is needed and it is advised to use more samples. Keywords: blood pressure, obesity, hypertension   Abstrak: Hipertensi merupakan penyakit tidak menular yang disebabkan oleh banyak faktor.  Dari sekian banyak faktor, obesitas merupakan salah satu penyebab terjadinya hipertensi pada saat ini, dan prevalensinya terus meningkat.  Penelitian ini bertujuan untuk menilai hubungan antara tekanan darah dengan obesitas pada remaja masyarakat Bolaang Mongondow Utara.  Desain penelitian yang digunakan adalah penelitian analitik dengan pendekatan cross sectional.  Subjek penelitian adalah siswa-siswi SMP, SMA, dan MTS di Kabupaten Bolaang Mongondouw Utara. Reponden yang mengikuti penelitian 60 anak,   terdiri dari 29 anak obes dan 30 anak non-obes.  Selanjutnya, sampel akan diukur tekanan darahnya.  Setelah itu, dilakukan analisis hubungan tekanan darah dengan IMT.  Hasil penelitian yang telah diolah menggunakan program statistik dengan uji mann-whitney menunjukkan tidak ada hubungan yang signifikan antara obesitas dengan tekanan darah sistolik dan diastolik ( p = 0,413, p = 0,938 ; p > 0,05). Dan dengan uji korelasi spearman didapatkan korelasi yang sangat lemah dan tidak terdapat hubungan antara obesitas dan tekanan darah sistolik (rs=  -0,082, p=0,536) dan didapatkan korelasi yang lemah dan tidak terdapat hubungan antara obesitas dan tekanan darah diastolik (rs=0,010, p=0,939) Kesimpulan: Berdasarkan hasil penelitian yang telah dilaksanakan di SMP, SMA, dan MTS di Kabupaten Bolaang Mongondouw Utara diperoleh hasil bahwa tidak ada hubungan antara tekanan darah dengan obesitas. Untuk saat ini masih perlu dilakukan penelitian lebih lanjut dan sebaiknya dengan jumlah sampel yang lebih banyak. Kata kunci: tekanan darah, obesitas, hipertensi
Perbedaan profil lipid pada remaja obes dan tidak obes di Kecamatan Bolangitang Barat Tandra, Hendry J.R.; Bodhi, Widhi; Kepel, Billy J.
e-Biomedik Vol 4, No 2 (2016): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v4i2.14266

Abstract

Abstract: Obesity might cause dyslipidemia, marked by increased cholesterol, triglycerides, and LDL levels, as well as reduced HDL level. Dyslipidemia is related to atherosclerosis that can result in cardiovascular diseases. This study was aimed to identify differences of lipid profiles in obese and non-obese teenagers at West Bolangitang, North Bolaang Mongondow. This was an observational analytical study with a cross sectional design conducted from October to November 2016. Subjects were 60 teenagers obtained by using consecutive sampling method and were divided into two groups: obese (29 teenagers) and non-obese (31 teenagers). Lipid profile examinations were performed on all of them. Statistical analysis of total cholesterol level of the two groups used independent t test (p=0.002) dan Pearson correlation test (p=0.028). The normality test of triglyseride level showed that data were not normally distributed, therefore, the analysis was continued with Mann-Whitney test (p=0.328) and Spearman correlation test (p=0.542). The normality test of LDL level showed that data were not normally distributed, therefore, the analysis was continued with Mann-Whitney test (p=0.004) and Spearman correlation test (p=0.032). The normality test of HDL level showed that data were not normally distributed, therefore, the analysis was continued with Mann-Whitney test (p=0.063) and Spearman correlation test (p=0.054). Conclusion: There were significant differences of total cholesterol and LDL levels but there were no significant differences of triglyceride and HDL levels between obese teenagers and non-obese teenagers.Keywords: lipid profile, adolescents, obesity. Abstrak: Obesitas dapat menyebabkan peningkatan lipid kolesterol, trigliserida, maupun LDL dan penurunan lipid HDL yang disebut dislipidemia. Dislipidemia berhubungan erat dengan terjadinya aterosklerosis yang dapat menimbulkan penyakit kardiovaskular. Penelitian ini bertujuan untuk mengetahui perbedaan profil lipid pada remaja obes dan remaja tidak obes di Kecamatan Bolangitang Barat, Kabupaten Bolaang Mongondow Utara. Jenis penelitian ialah observasional analitik dengan desain potong lintang. Penelitian dilaksanakan pada bulan Oktober dan November 2016 dengan sampel penelitian berjumlah 60 remaja terdiri dari kelompok remaja obes (29 orang) dan kelompok remaja tidak obes (31 orang) yang diperoleh dengan metode consecutive sampling. Pemeriksaan profil lipid dilakukan pada semua remaja. Uji statistik terhadap kadar kolesterol total antara kedua kelompok menggunakan uji independent t test (p=0,002) dan uji Pearson correlation (p=0,028). Uji normalitas terhadap kadar trigliserida mendapatkan data tidak terdistribusi normal sehingga dilanjutkan dengan uji Mann-Whitney (p=0,328) dan uji korelasi Spearman (p=0,542). Uji normalitas terhadap kadar LDL mendapatkan data tidak terdistribusi normal sehingga dilanjutkan dengan uji Mann-Whitney (p=0,004) dan uji korelasi Spearman (p=0,032). Uji normalitas terhadap kadar HDL mendapatkan data tidak terdistribusi normal sehingga dilanjutkan dengan uji Mann-Whitney (p=0,063) dan uji korelasi Spearman (p=0,054). Simpulan: Terdapat perbedaan bermakna dalam hal kadar kolesterol total dan LDL, tetapi tidak terdapat perbedaan bermakna dalam hal kadar trigliserida dan HDL antara remaja obes dan tidak obes. Kata kunci: profil lipid, remaja, obesitas
Identifikasi Bakteri Resisten Merkuri Menggunakan Metode 16SrRNA terhadap Plak Gigi pada Pasien Pengguna Tumpatan Amalgam Tanumihardja, Christofel A.N.; Kepel, Billy; Bodhi, Widhi
e-Biomedik Vol 5, No 2 (2017): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v5i2.18514

Abstract

Abstract: Amalgam is a popular dental filling due to its cheaper price than other dental fillings. Basically, amalgam is an alloy, consists of two or more metals; one of them is mercury. The unfavorable thing about this alloy is that its vapor in the oral cavity can trigger the development of mercury-resistant bacteria. This type of bacteria has an enzyme called mercury reductase that can reduce Hg2+ to Hg0. 16SsRNA is a gene that contains important information to describe the prokaryotic type. This study was aimed to identify the type of mercury-resistant bacteria from dental plaque of patients with amalgam fillings. Samples were taken from the dental plaques. Isolation of DNA, sequensing of 16SsRNA gene by using PCR, and online BLAST through GenBank NCBI, and finally looking for the closest relative using a phylogenetic tree were performed in the Pharmacy Laboratory, Faculty of Mathematics and Science. The result of BLAST showed 4 types of bacteria, and the closest relative is B. thuringiensis. Conclusion: The type of mercury-resistant bacteria found in dental plaques was Bacillus thuringiensis.Keyword: amalgam, mercury resistant bacteria, dental plaques, 16SsRNA, PCR Abstrak: Amalgam adalah suatu logam campuran yang terdiri dari dua atau beberapa logam yang salah satunya adalah merkuri atau air raksa. Amalgam sebagai bahan tumpatan sampai saat ini masih banyak digunakan oleh dokter gigi karena harganya yang relatif murah. Namun penggunaan amalgam ini dapat melepaskan uap merkuri selama berada di dalam rongga mulut. Penggunaan amalgam ini memicu munculnya bakteri yang resisten terhadap merkuri dimana bakteri dapat mereduksi Hg2+ menjadi Hg0 melalui enzim yang menginduksi merkuri reduktase. 16SsRNA adalah gen yang menampung informasi-informasi penting agar mendeskripsikan jenis-jenis prokariotik. Penelitian ini bertujuan untuk mengidentifikasi bakteri resisten merkuri pada plak gigi pasien pengguna tumpatan amalgam menggunakan metode PCR. Jenis penelitian ialah deskriptif observatif. Sampel diambil dari plak gigi pasien pengguna tumpatan amalgam di Laboratorium Farmasi Fakultas MIPA. Dilakukan langkah-langkah untuk isolasi DNA, sekuensing gen 16SsRNA menggunakan PCR, kemudian dilakukan BLAST secara online melalui GenBank NCBI lalu dicari kekerabatannya menggunakan pohon filogenetik. Hasil BLAST mendapatkan 4 jenis bakteri, dan kekerabatan terdekatnya ialah Bacillus thuringiensis. Simpulan: Jenis bakteri resisten terhadap merkuri pada plak gigi ialah Bacillus thuringiensis.Kata kunci: amalgam, bakteri resisten merkuri, plak gigi, 16SsRNA, PCR
GAMBARAN BAKTERI RESISTENSI HgCl2 DAN FENIL MERKURI YANG DIAMBIL DARI FESES, URIN, DAN KARANG GIGI PADA INDIVIDU YANG TINGGAL DI DAERAH PESISIR PANTAI DI DESA KEMA II Rondonuwu, Glenaldy; Kepel, Billy J.; Bodhi, Widhi
eBiomedik Vol 2, No 3 (2014): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.2.3.2014.6007

Abstract

Abstract: Mercury as one of the dangerous contaminants, are neurotoxins and enter into aquatic ecosystems through atmospheric deposition or derived from industrial waste externalization. Methods: This research using descriptive and exploratory method. After getting the sample (feces, urine, tartar), the study followed by laboratory tests. Result: It was found that bacterias resistant to HgCl2: streptococcus sp, E. coli, and clostridium sp, while the bacterias that resistant to phenyl mercury: bacillus sp and sp aeroccus. Keywords: Bacteria Resistance, HgCl2, Phenyl Mercury, Feces, Urine, Tartar, Coastal Marine. Abstrak: Merkuri sebagai salah satu zat pencemar yang berbahaya, bersifat neurotoksin dan masuk ke dalam ekosistem akuatik melalui deposisi atmosferik, maupun berasal dari eksternalisasi limbah industry. Metode: Penelitian ini bersifat deskriptif dan bersifat eksploratif. Kemudian setelah mendapatkan sampel (feses, urin, karang gigi), penelitian dilanjutkan dengan pemeriksaan lab. Hasil: Didapatkan bakteri yang resisten terhadap HgCl2 : streptococcus sp, E.Coli, dan clostridium sp. Sedangkan bakteri yang resisten terhadap fenil merkuri: bacillus sp dan aeroccus sp. Kata kunci: Bakteri Resistensi, HgCL2, Fenil Merkuri, Feses, Urin, Karang Gigi, Daerah Pesisir Pantai.
Hubungan kadar asam urat dengan status gizi pada remaja di Kecamatan Bolangitang Barat Kabupaten Bolaang Mongondow Utara Budiono, Alvin; Manampiring, Aaltje E.; Bodhi, Widhi
e-Biomedik Vol 4, No 2 (2016): eBiomedik
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ebm.v4i2.14605

Abstract

Abstract: Hyperuricemia is one state that is now likely to be obtained at adolescent. The state of hyperuricemia can be influenced by many factor, for example is the nutritional status. This study aims to determine the correlation between uric acid levels and nutritional status in adolescents in the District of West Bolangitang. This study is cross-sectional analytic. The subjects were adolescents from middle and high school in the District of West Bolangitang. Respondents were entering the study were 60 children, 16 boys and 44 girls. From the results obtained hyperuricaemia 16 children, and 12 (75%) were obese, 1 underweight, normal 2 and 1 overweight. Conclusion: There is a correlation between uric acid levels and nutritional status in adolescents in the District of West BolangitangKeywords: hyperurisemia, uric acid, nutritional status Abstrak: Hiperurisemia merupakan salah satu keadaan yang sekarang cenderung didapatkan pada usia yang lebih muda. Keadaan hiperurisemia ini dapat dipengaruhi oleh berbagai hal, salah satu contohnya adalah status gizi. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar asam urat dengan status gizi pada remaja di Kecamatan Bolangitang Barat. Penelitian ini bersifat cross-sectional analitik. Subjek penelitian ini adalah remaja dari SMP dan SMA di Kecamatan Bolangitang Barat. Responden yang mengikuti penelitian berjumlah 60 anak, 16 laki-laki dan 44 perempuan. Dari hasil pemeriksaan didapatkan 16 anak hiperurisemia, dan 12 (75%) diantaranya obesitas, 1 underweight, 2 normal dan 1 overweight. Simpulan: Terdapat hubungan antara kadar asam urat dengan status gizi pada remaja di Kecamatan Bolangitang Barat Kata kunci: hiperurisemia, kadar asam urat, status gizi
EFEK ANTIHIPERGLIKEMIA DARI EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) YANG DIINDUKSI SUKROSA Manurung, Sondang; Barung, Elisabeth; Bodhi, Widhi
PHARMACON Vol 1, No 1 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.447

Abstract

This study aims to determine the effects of pericarp extracts of mangosteen antihiperglikemia inwistar strain male mice induced sucrose and compare its effectiveness with glibenclamide. Themethod used is a laboratory experiment using a Completely Randomized Design. Subjects in the formof 15 male white rats tail with weight ranging from 100g-210g are divided into 3 groups of eachgroup as much as 5 tails. The treatment begins with administration of sucrose solution is adjusted tothe weight of each rat. On the second day evening, the test animals fasted for twelve hours, and thethird day in the morning followed by blood glucose level measured sucrose solution, after thirtyminutes of administration of sucrose solution was measured blood glucose level, the first group weregiven distilled water, the second group were given mangosteen rind extract 20%, The third group wasgiven glibenclamide and 0.3030 mg/g weight had made suspension in 1% CMC solution is thenmeasured blood sugar test animals one, two, three, and four hours. Data were analyzed with spssver.17, the real difference between treatments was tested by one way ANOVA. The results ofstatistical analysis gave a significant difference p-value=0.00 (p <0.05) in which the extract cansuppress the KBM 20% increase in KGD in mice and provide similar effectiveness withglibenclamide.Key Word : Garcinia mangostana L., Rattus norvegicus L., Sucrose, CMC
Co-Authors Aaltje E. Manampiring Aaltje Manampiring Billy J. Kepel Billy Kepel Budiono, Alvin Elisabeth Barung Fatimawali . Glenaldy Rondonuwu Ratulangi, Andrew Johanes Sondang Manurung Tandra, Hendry J.R. Tanumihardja, Christofel A.N.