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All Journal Indian Journal of Forensic Medicine & Toxicology
Essam F.A.Al-Jumaili
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Public Health

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Study Some Kinetic Parameters for Purified Arginase from Two Different Sources: Red Blood Cells and Serum of( Healthy and TypeII Diabetic Patient) Fayhaa M. Khaleel; Essam F.A.Al-Jumaili
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14551

Abstract

Kinetics parameters for arginase that purified from RBCs, and serum (control, and diabetic patients)revealed that the Km values are (200, 416, and 333mM), Vmax values are (47, 5.5, and 9 U/min),andThe values of catalytic constant Kcat are (174, 45.8, and 81.8 min-1). The effect of atrovastatin was alsostudied on serum arginase, the arginase activity is decreasing by increasing statin concentration, whereinat the lower concentration (0.112 mg/ml) the allosteric regulation percentage is 26% and it is ongoing untilreaching its maximum (85%) at the highest concentration (0.9mg/ml). In conclusion affinity of arginase tothe L-arginine, and its velocity is more in RBCs, and serum patients compared with serum controls, andstatin appears to be an allosteric regulator for arginase.
Co-Authors Fayhaa M. Khaleel